Intake of soy foods regulates the development of metabolic syndrom
| Project/Area Number |
25350126
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKAI Tohru 徳島大学, 大学院医歯薬学研究部, 教授 (40274196)
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| Research Collaborator |
SHUTO Emi
KIOKA Miku
NAKAMOTO Mariko
MITANI Mami
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大豆 / アレルギー / 免疫 / 疫学 / メタボリックシンドローム / エクオール / 内臓脂肪 / 炎症 / イソフラボン / 肥満 |
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| Outline of Final Research Achievements |
In this study, we examined effect of soy-related ingredients on the development of metabolic syndrome in animal model and human study. Treatment of soy isoflavone equol improved blood glucose levels following oral glucose or insulin administration in mice fed high-fat diet. Treatment equol reduced visceral fat weight. Equol tended to decrease mRNA expression of inflammatory cytokines in visceral fat.
We studied 452 Japanese individuals who completed a baseline (2009-2010) and follow-up survey (2012-2013). Abdominal circumference, systolic and diastolic blood pressure, blood glucose level, serum triglyceride and HDL-cholesterol levels were used as component of metabolic syndrome. The standard partial regression coefficient (β) for abdominal circumference of miso intake was -0.208 (p=0.016) in men under 40 years, though there is no significant association between miso intake and components of metabolic syndrome in men 40 and older.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fatty liver in KK-Ay mice.2014
Author(s)
Hosaka T., Sasaga S., Yamasaka Y., Nii Y., Edazawa K., Tsutsumi R., Shuto E., Okahisa N., Iwata S., Tomotake H., and Sakai T.
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Journal Title
J. Med. Invest.
Volume: 61
Pages: 342-352
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treatment with buckwheat bran extract prevents the elevation of serum triglyceride levels and fattu liver in KK-Ay mice.2014
Author(s)
Hosaka T., Sasaga S., Yamasaka Y., Nii Y., Edazawa K., Tsutsumi R., Shuto E., Okahisa N., Iwata S., Tomotake H., and Sakai T.
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Journal Title
J. Med. Investi.
Volume: 3
Related Report
Peer Reviewed
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[Journal Article] Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population2013
Author(s)
Nakamoto M., Arisawa K., Uemura H.,Katsuura S, Takami H., Sawachika F., Yamaguchi M., Juta T., Sakai T., Toda E., Mori K., Hasegawa M., Tanto M., Shima M., Sumiyoshi Y., Morinaga K., Kodama K., Suzuki T., Nagai M., and Satoh H.
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Journal Title
International Archives of Occupational and Environmental Health
Volume: 86
Pages: 849-859
Related Report
Peer Reviewed
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[Journal Article] Cysteine string protein 1 (CSP1) modulates insulin sensitivity by attenuating glucose transporter 4 (GLUT4) vesicle docking with the plasma membrane.2013
Author(s)
Jambaldoei B., Terada E., Hosaka T., Kishuku Y., Tomioka Y., Iwashima K., Hirata Y., Teshigawara K., Le C.T.K., Nakagawa T., Harada N., Sakai T., Sakaue H., Matsumoto T., Funaki M., Takahashi A., and Nakaya Y.
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Journal Title
J. Med. Investi.
Volume: 60
Pages: 197-204
NAID
Related Report
Peer Reviewed
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