Can oral administration of TG type gamma-linolenic acid improve the lypodystrophy?

• Project/Area Number: 25350127
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Nagasaki University
• Principal Investigator: OIKAWA Daichi 長崎大学, 教育学部, 准教授 (90571216)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: リポジストロフィー / 共役リノール酸 / TG型γ-リノレン酸 / 母子栄養

Outline of Final Research Achievements

In this study, we tried to improve the lipodystrophy syndrome derived from conjugated linoleic acid (CLA) by oral ingestion of "triacylglycerol (TG) type γ- linolenic acid (GLA)". The mitigation effect of the lipodystrophy syndrome was weaker at a dose of this TG GLA, ingested GLA was able to newly discovered that reducing the content ratio of the liver. In addition, CLA intake of the mother mice was found to induce lipodystrophy onset of pups. Moreover, it was found newly that TG GLA intake of mother mice were enhanced the inhibitory effect of lipodystrophy onset of male pups.

Research Products

• [Journal Article] The relationship between liver lipid accumulation and changes in plasma amino acids in mice challenged with carbon tetrachloride. (2016)
  • Author(s): Shinya Takagi, Daichi Oikawa, Hiromi Ikeda, Nozomi Tateiwa, Kazunori Koba, Vishwajit. S. Chowdhury, Shinobu Yasuo and Mitsuhiro Furuse.
  • Journal Title: Animal nutrition Volume: 1
  • Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 共役リノール酸の摂取が脂質代謝に与える影響 (2015)
  • Author(s): 及川大地, 岸本梨江, 谷口由夏, 本村菜摘
  • Organizer: 日本家政学会 第67回大会
  • Place of Presentation: いわて県民情報センター アイーナ（岩手県盛岡市）
  • Year and Date: 2015-05-23 – 2015-05-24
• [Presentation] 共役リノール酸の摂取が脂質代謝に与える影響 (2015)
  • Author(s): 及川大地, 岸本梨江, 谷口由夏, 本村菜摘
  • Organizer: 日本家政学会第67回大会
  • Place of Presentation: アイーナ盛岡 (岩手県盛岡市)
  • Year and Date: 2015-05-22
• [Presentation] The effect of Goto camellia oil administration on skin and liver composition in mice (2015)
  • Author(s): Daichi Oikawa, Ayano Yoshida, Shunpei Miyazaki, Fumie Muto.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Pacifico Yokohama (Yokohama, Japan)
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Remarks] 長崎大学研究者総覧データベースシステム及川大地
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST?ISTActId=FINDJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461
• [Remarks] 長崎大学教員個人業績
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST?ISTActId=RESULTSJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461
• [Remarks] researchmap-及川大地
  • URL: http://researchmap.jp/read0129196
• [Remarks] 長崎大学 研究者総覧データベースシステム（及川大地）
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST?ISTActId=FINDJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461
• [Remarks] 長崎大学 教員個人業績（及川大地）
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST?ISTActId=RESULTSJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461&search_nendo=
• [Remarks] 研究者総覧データベースシステム（及川大地）
  • URL: http://research.jimu.nagasaki-u.ac.jp/IST?ISTActId=FINDJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461
• [Remarks] 長崎大学 教員個人業績（及川大地）
  • URL: http://gyoseki.jimu.nagasaki-u.ac.jp/IST?ISTActId=RESULTSJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=100000461
• [Remarks] researchmap
  • URL: http://researchmap.jp/read0129196