| Project/Area Number |
25350131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Akagawa Mitsugu 大阪府立大学, 生命環境科学研究科(系), 講師 (70405356)
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| Co-Investigator(Renkei-kenkyūsha) |
ISHII Takeshi 神戸学院大学, 栄養学部, 准教授 (50448700)
SHIBATA Takahiro 名古屋大学, 生命農学研究科, 准教授 (80447838)
KAI Kenji 大阪府立大学, 大学院生命環境科学研究科, 講師 (40508404)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 香辛料 / 機能性食品 / ２型糖尿病 / インスリン抵抗性 / プロテインチロシンホスファターゼ1B / 2型糖尿病 / 機能性食品成分 |
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| Outline of Final Research Achievements |
In this study, we searched for insulin signal-activating component from spices and evaluated its anti-diabetic effects. We demonstrated that isothiocyanates found in cruciferous vegetables potently inhibits protein tyrosine phosphatase 1B (PTP1B), which negatively regulates insulin signaling. Moreover, we found that phenethyl isothiocyanate induces the ligand-independent activation of insulin signaling by inhibiting cellular PTP1B and increases glucose uptake in mouse C2C12 myotubes.
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