| Project/Area Number |
25350136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | The Open University of Japan |
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Principal Investigator |
Kojo Shosuke 放送大学, 教養学部, 教授 (10108988)
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| Co-Investigator(Kenkyū-buntansha) |
ICHI Ikuyo お茶の水女子大学, 大学院人間文化創成科学研究科, 講師 (50403316)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 酸化ストレス / セラミド / スフィンゴミエリナーゼ / 動脈硬化 / 糖尿病 / カテキン / アルツハイマー病 / アミロイド / 脂質代謝 / miRNA / オキシステロール / ミード酸 / ラセミ化 / アポEノックアウトマウス / 老化 / D-アスパラギン酸 |
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| Outline of Final Research Achievements |
Oxidative stress is assumed to cause aging and diseases of the elderly such as cancer, atherosclerosis, and complications of diabetes. Although polyphenols are expected to scavenge reactive oxygen species (ROS) in vivo, it is fully established that these unphysiological food factors do not effectively scavenge ROS in vivo. Then we must clarify the mechanism, by which oxidative stress causes diseases. We found that sphingomyelinase (an enzyme forming ceramide) was activated by oxidative stress and that the resulting ceramide was a risk factor of atherosclerosis and complications of diabetes using animal experiments. It is well known that ceramide, a physiological lipid causes apoptosis (cell death). In addition we found that green tea catechins inhibited the activation of sphingomyelinase by reduction reaction at physiological concentration in the blood. Therefore it is possible that catechins inhibit the development of atherosclerosis.
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