| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
【Aim】High intake of trans fatty acid (TFA) increases the risk of cardiovascular disease and atherosclerosis. This study analyzed the mechanism of atherosclerosis induction by elaidic acid (EA), which is a component of industrially produced TFA. 【Methods】Human breast carcinoma-derived YMB-1-E cells and human monocytic leukemia-derived U937 cells were used for the exsperiments. 【Results】EA strongly suppressed the anti-arteriosclerosis protein adiponectin expression. EA promoted in PMA-stimulated U937 cells, expression of differentiation marker antigens CD68 and CD147, expression of TNF-α, lipid accumulation and activation of phagocytosis. Experiments with TLR4 inhibitors indicated that elaidic acid exacerbates atherosclerotic changes via TLR4 signal transduction pathway. These facts suggest the possibility to suppress the development of pathogenesis of atherosclerosis by control the function of TLR4.
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