| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Outline of Final Research Achievements |
Human salivary amylase gene (AMY1) has copy number (CN) variation. The CN is reported to correlate with amount and activity of salivary amylase in adults. Salivary amylase activity is not present at birth and rises to reach maximum levels by puberty. Dietary habit is also reported to affect the activity. This study aimed to clarify how AMY 1 CN and dietary habit affect the development of salivary amylase activity in children. A survey was conducted at Nagano city to collect saliva and questionnaires from 234 nursery and 945 preliminary school children. AMY1 CN was assessed in 204 nursery school children, and DNA was prepared in 943 preliminary school children. Salivary amylase activity before breakfast was associated with AMY1 CN and bedtime in nursery school boys.
In addition to above, the human saliva was suggested to have protease activated at acidic condition. Analysis of questionnaire gave some associations of children and maternal health with lifestyles.
|
