Does copy number variation of AMY1 gene affect dieatary intake and development in children?
| Project/Area Number |
25350141
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Juntendo University |
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Principal Investigator |
Yoshio Suzuki 順天堂大学, スポーツ健康科学部, 准教授 (30612395)
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| Co-Investigator(Renkei-kenkyūsha) |
KADOYA Haruka 順天堂大学, スポーツ健康科学部, 准教授 (10420879)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | amylase / saliva / AMY1 / development / protease / copy number variation / lifestyle / アミラーゼ / 唾液 / 発達 / プロテアーゼ / コピー数多型 / 生活習慣 / 生活環境 |
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| Outline of Final Research Achievements |
Human salivary amylase gene (AMY1) has copy number (CN) variation. The CN is reported to correlate with amount and activity of salivary amylase in adults. Salivary amylase activity is not present at birth and rises to reach maximum levels by puberty. Dietary habit is also reported to affect the activity. This study aimed to clarify how AMY 1 CN and dietary habit affect the development of salivary amylase activity in children. A survey was conducted at Nagano city to collect saliva and questionnaires from 234 nursery and 945 preliminary school children. AMY1 CN was assessed in 204 nursery school children, and DNA was prepared in 943 preliminary school children. Salivary amylase activity before breakfast was associated with AMY1 CN and bedtime in nursery school boys.
In addition to above, the human saliva was suggested to have protease activated at acidic condition. Analysis of questionnaire gave some associations of children and maternal health with lifestyles.
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Report
(4 results)
Research Products
(10 results)
