Exploration of antithrombotic substanse and development of new functional foods that prevent aging induced thrombotic conditions
| Project/Area Number |
25350144
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Teikyo University |
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Principal Investigator |
Ohkura Naoki 帝京大学, 薬学部, 准教授 (60349256)
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| Co-Investigator(Kenkyū-buntansha) |
Oishi KATSUTAKA 独立行政法人産業技術総合研究所, 生物機能工学研究部門, 研究グループ長 (60349256)
ATSUMI GEN-ICHI 帝京大学, 薬学部, 教授 (70276608)
OSHITARI TETSUTA 帝京大学, 薬学部, 教授 (00279043)
大石 勝隆 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門生物時計研究グループ, グループリーダー (50338688)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIGUCHI MASAHIKO 大阪薬科大学, 薬学部, 教授 (00278590)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 機能性食品 / 血栓症 / 加齢 / 血栓 / 健康食品 / 日内変動 |
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| Outline of Final Research Achievements |
The study aimed to identify new health foods that improve thrombotic condition induced by aging. We explored antithrombotic substance and found some new candidates. We showed that Ashitaba have antithrombotic potential in aged mice. We also showed that the geranyl group in xanthoangelol from Ashitaba played an important role in this process. This study showed that the intake of health food might have potential for preventing thrombotic disorders by decreasing prothrombotic states in elderly. However, further investigation is needed with respect to considering circadian rhythm of blood coagulation.
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Report
(4 results)
Research Products
(22 results)
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[Presentation] 明日葉カルコンの血小板凝集抑制作用2015
Author(s)
藤井文音, 藤井文音, 中山亜希子, 薄葉ゆかり, 石橋賢一, 大西克典, 谷口雅彦, 馬場きみ江, 大藏直樹, 厚味厳一
Organizer
第16回Pharmaco-Hematologyシンポジウム
Place of Presentation
東京都渋谷区
Year and Date
2015-06-13
Related Report
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