Cholesterol ingestion and fatty acid composition/insulin resistance during progression of non-alcoholic steatohepatitis
| Project/Area Number |
25350150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
KITAMORI Kazuya 金城学院大学, 生活環境学部, 准教授 (80387597)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Daisuke 金城学院大学, 薬学部, 准教授 (70434553)
NAKAJIMA Tamie 中部大学, 公私立大学の部局等, 教授 (10020794)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | NASH / コレステロール / 脂肪酸 |
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| Outline of Final Research Achievements |
Excessive accumulation of lipid has been considered to be a cause of lifestyle-related diseases but in recent years, changes in the quality of fatty acids is indicated as important. This study used SHRSP5/Dmcr, a non-alcoholic steatohepatitis (NASH) model we developed, in which the disease progresses to fat accumulation/hepatitis/fibrosis upon ingestion of a high-fat and high-cholesterol (HFC) diet, and WKY (control). The rats were fed the HFC diet, a high-fat (HF) diet with no added cholesterol, or a common diet, and measurements of fatty acid composition and inflammation/fibrosis were taken. The cholesterol-added diet caused greater severity of NASH pathology despite having the same lipid content as the HF diet. In addition, the severity was remarkably greater in SHRSP5/Dmcr than in WKY.
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Report
(4 results)
Research Products
(4 results)
