Basic study on improvement of lipid nutrition for perinatal mental disorder
| Project/Area Number |
25350151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Kinjo Gakuin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大西 浩之 北里大学, 医療衛生学部, 講師 (90523316)
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| Co-Investigator(Renkei-kenkyūsha) |
OHARA Naoki 金城学院大学, 薬学部, 教授 (20426422)
YAMADA Kazuyo 金城学院大学, 薬学部, 教授 (90080217)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 多価不飽和脂肪酸 / 脳神経系 / 周産期 / ストレス / 神経栄養因子 |
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| Outline of Final Research Achievements |
In perinatal period, female mice were fed high-linoleate safflower oil diet (n-3 fatty acid restricted diet; SAF) or perilla oil diet (PER). On the other hand, nonperinatal mice were fed same terms. On the cerebral cortex fatty acid composition, Arachidonic acid (AA) was significantly increased by SAF diet.
Brain-derived neurotrophic facor (BDNF) has been suggested to be associated with psychiatric disorders such as depression. In the cerebral cortex, BDNF contents of PER (with pups) was significantly lower than that of PER (without pups). SAF (without pups) showed a lower tendency than PER (without pups).
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Report
(5 results)
Research Products
(13 results)
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[Journal Article] Effects of arachidonic acid intake on inflammatory reactions in dextran sodium sulphate-induced colitis in rats2015
Author(s)
Naito Y, Ji X, Tachibana S, Aoki S, Furuya M, Tazura Y, Miyazawa D, Harauma A, Moriguchi T, Nagata T, Iwai N, Ohara N
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Journal Title
Br J Nutr
Volume: 114
Issue: 5
Pages: 734-745
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Changes by canola (rapeseed) oil ingestion of steroid hormone production in SHRSP2016
Author(s)
S Yagi, M Nishikawa, H Hanai, S Suzumura, Y Naito, K Tatematsu, D Miyazawa, Y Hashimoto, A Yamamura, H Ohnishi, N Ohara, H Okuyama
Organizer
日本薬理学会第89回年会
Place of Presentation
横浜
Year and Date
2016-03-10
Related Report
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