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Studies on the possible roles of fat soluble vitamins in the prevention of osteoporotic fracture and re-fracture.

Research Project

Project/Area Number 25350157
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionKyoto Women's University

Principal Investigator

Tanaka Kiyoshi  京都女子大学, 家政学部, 教授 (90227132)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords骨粗鬆症 / 骨折 / ビタミンD / ビタミンK / 低栄養 / アルブミン / 腎機能 / 身長低下 / 食事パターン分析 / ビタミン
Outline of Final Research Achievements

Vertebral fracture (VFx), most prevalent of all osteoporotic fracture, is too often overlooked. We have shown that height loss and current height/knee ratio can be useful screening tools for VFx screening. We have demonstrated that vitamin D production in the skin plays an essential role by studying the vitamin D status in patients with xeroderma pigmentosum who are in need of complete photoprotection. In a cohort of patients with newly diagnosed VFx, we have observed that decreased serum albumin concentration and eGFR, hence malnutrition and impaired renal function are significant predictors for mortality. We have also found that measurement of lower leg muscle strength is quite useful for predicting the gait speed and daily physical performance, for which vitamin D status has greatly contributed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 2 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum (XP)- A under strict sun-protection2015

    • Author(s)
      Kuwabara A, Tsugawa N, Tanaka K, Uejima Y, Ogawa J, Otao N, Yamada N, Masaki T, Nishigori C, Moriwaki S, Okano T.
    • Journal Title

      European Journal of Clinical Nutrition

      Volume: Epub ahead of print Issue: 6 Pages: 693-9

    • DOI

      10.1038/ejcn.2015.1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of hypoalbuminemia and decreased renal function to the increased mortality after newly diagnosed vertebral fracture in Japanese subjects.2015

    • Author(s)
      Nakano T, Kuwabara A, Mizuta H, Tanaka K
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: e-pub

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] High prevalence of vitamin D deficiency in patients with xeroderma pigmentosum-A under strict sun protection.2015

    • Author(s)
      Kuwabara A, Tsugawa N, Tanaka K, Uejima Y, Ogawa J, Otao N, Yamada N, Masaki T, Nishigori C, Moriwaki S, Okano T.
    • Journal Title

      European Journal of Clinical Nutrition

      Volume: Epub

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Detective value of historical height loss and current height/knee height ratio for prevalent vertebral fracture in Japanese postmenopausal women.2014

    • Author(s)
      Yoh K, Kuwabara A, Tanaka K
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: NA Issue: 5 Pages: 533-538

    • DOI

      10.1007/s00774-013-0525-y

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association with vitamin E intake and hypertension: Results from the re-analysis of the National Health and Nutrition Survey.2014

    • Author(s)
      Kuwabara A, Nakade M, Tamai H, Tsuboyama-Kasaoka N, Tanaka K
    • Journal Title

      Journal of Nutritional Science and Vitaminology

      Volume: NA

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Decreased serum albumin level and renal function are the risk for mortality after newly diagnosed vertebral fracture (VFx) in Japanese subjects.2015

    • Author(s)
      Kuwabara A, Nakano T, Tanaka K
    • Organizer
      American Society for Bone and Mineral Research, 37th Annual Meeting
    • Place of Presentation
      Seattle
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Significance of Historical Height Loss in the Nutritional Assessment of the Elderly.2015

    • Author(s)
      Tanaka K, Kuwabara A, Ohta J, Seki M, Okajima R, Sato T, Yoh K
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] High prevalence of vitamin B12 deficiency in patients with Crohn's disease.2015

    • Author(s)
      Ao M, Tsuji H, Kosaka Y, Noda A, Nakase H, Shide H, Chiba T, Inagaki N, Tanaka K
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostic value of leg muscle strength measurement for sarcopenia in the elderly.2015

    • Author(s)
      Ohta J, Takaoka H, Seki M, Okajima R, Tanaka K
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vitamin D and K on fracture risks and quality of life2015

    • Author(s)
      Tanaka K
    • Organizer
      9th Asia Pacific Conference on Clinical Nutrition
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2015-01-26 – 2015-01-29
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] クローン病患者におけるビタミン欠乏症の調査2015

    • Author(s)
      辻 秀美、幣 憲一郎、仲瀬 祐志、田中 清、稲垣 暢也
    • Organizer
      第18回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 整形外科外来受診ロコモティブシンドローム患者に対する食事調査2015

    • Author(s)
      関 桃代、太田淳子、岡島理奈、桑原晶子、田中清
    • Organizer
      第18回日本病態栄養学会
    • Place of Presentation
      京都
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Research-status Report
  • [Presentation] High prevalence of vitamin D deficiency in patients with xeroderma pigmentosum-A under strict sun protection.2014

    • Author(s)
      Kuwabara A, Tsugawa N, Tanaka K, Uejima Y, Ogawa J, Otao N, Yamada N, Masaki T, Nishigori C, Moriwaki S, Okano T.
    • Organizer
      American Society for Bone and Mineral Research, 36th Annual Meeting
    • Place of Presentation
      Houston, TX USA
    • Year and Date
      2014-09-12 – 2014-09-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Clinical usefulness of historical height loss and current height/knee height ratio in the nutritional assessment of the elderly.2013

    • Author(s)
      Kuwabara A, Tanaka K, Yoh K.
    • Organizer
      IUNS 20th International Congress of Nutrition
    • Place of Presentation
      Granada, Spain
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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