| Project/Area Number |
25350159
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Soai University |
|---|
Principal Investigator |
Shojo Aiko 相愛大学, 人間発達学部, 准教授 (40517265)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Kitamura Shinichi 大阪府立大学, 生命環境科学研究科, 教授 (60117869)
Fujiwara Nagatoshi 帝塚山大学, 現代生活学部食物栄養学科, 教授 (80326256)
Mizuno Seiko 相愛大学, 人間発達学部, 教授 (90190652)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 食用担子菌類 / 腸管免疫 / 腸内細菌 / IgA / パイエル板 / 担子菌類 / 糖脂質 / 脂質 / 担子菌 |
|---|
| Outline of Final Research Achievements |
From the data of high-performance liquid chromatography analysis, following results had be demonstrated. The glucosylceramide of edible basidiomycete fruiting bodies had a large difference in that varieties and contained amount. The Differences with the contained amount of neutral lipids and the polarity of complex lipids demonstrated. When the peyer's patch were co-cultured with total lipid of edible basidiomycete fruiting bodies, the cytokines as IL-4, IL-6 and IL-10 were increased. The increased these cytokines in response to total lipids of edible basidiomycete fruiting bodies in the diet compared with a control diet. From these results suggest that the B cell has class-switched to IgA+B cell by the response to IL-4, these class-switched IgA+B cell increased IgA production in response to IL-6.
|
