Intestinal immunomodulatory and anti-allergic activities of the lipids components in edible basidiomycete fruit body.
| Project/Area Number |
25350159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Soai University |
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Principal Investigator |
Shojo Aiko 相愛大学, 人間発達学部, 准教授 (40517265)
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| Co-Investigator(Kenkyū-buntansha) |
Kitamura Shinichi 大阪府立大学, 生命環境科学研究科, 教授 (60117869)
Fujiwara Nagatoshi 帝塚山大学, 現代生活学部食物栄養学科, 教授 (80326256)
Mizuno Seiko 相愛大学, 人間発達学部, 教授 (90190652)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 食用担子菌類 / 腸管免疫 / 腸内細菌 / IgA / パイエル板 / 担子菌類 / 糖脂質 / 脂質 / 担子菌 |
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| Outline of Final Research Achievements |
From the data of high-performance liquid chromatography analysis, following results had be demonstrated. The glucosylceramide of edible basidiomycete fruiting bodies had a large difference in that varieties and contained amount. The Differences with the contained amount of neutral lipids and the polarity of complex lipids demonstrated. When the peyer's patch were co-cultured with total lipid of edible basidiomycete fruiting bodies, the cytokines as IL-4, IL-6 and IL-10 were increased. The increased these cytokines in response to total lipids of edible basidiomycete fruiting bodies in the diet compared with a control diet. From these results suggest that the B cell has class-switched to IgA+B cell by the response to IL-4, these class-switched IgA+B cell increased IgA production in response to IL-6.
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Report
(4 results)
Research Products
(4 results)
