| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Feeding behavior independent of hunger and satiety causes maintenance or exacerbation of obesity. It has been suggested that leptin, an adipokine, and dopamine, a neurotransmitter, interact in the ventral tegmental area (VTA), which is the origin of the dopaminergic mesolimbic system and critical for food reward. In the electrophysiological research using mice, we found the following results; (1) leptin directly inhibited spontaneous activity of VTA dopamine neurons and attenuated dopamine receptor-mediated effect on these neurons, (2) recovery time from the leptin-induced direct inhibition of VTA dopamine neurons was negatively correlated with body weight in high fat diet-induced obese mice.
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