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A study related to the increase of gastric mucus induced by the intake of soluble dietary fiber viscous solution.

Research Project

Project/Area Number 25350172
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Eating habits
Research InstitutionUniversity of Shizuoka (2014-2015)
University of Shizuoka,Shizuoka College (2013)

Principal Investigator

Takabayashi Fumiyo  静岡県立大学, 看護学部, 准教授 (80167486)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords食物繊維 / 胃粘膜 / 粘膜厚 / 粘液産生 / 粘性溶液 / 腺粘液 / 食物線維 / 胃潰瘍 / 食物せんい溶液
Outline of Final Research Achievements

The effects of soluble dietary fiber ( Methyl cellulose, Sodium alginate, Guar Gum and Agarose) solutions intake on a stomach mucosa were investigated. The viscosity of soluble dietary fiber solutions were adjusted to 10mPa・s or 40mPa・s and were given as a drink for two or four weeks. Stomach mucosa was thickened and the gland mucous cells which were indicated by HIK1083 stained area was increased by the intake of soluble dietary fiber solution. Methyl cellulose and Guar Gum solutions were more effective than others. And a high molecular weight soluble dietary fiber solution was more effective than that of low molecular weight in a same kind of soluble dietary fiber, though the total intake of dietary fiber was much smaller.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Viscous methyl cellulose solution thickens gastric mucosa and increases the number of mucous cells in mice2013

    • Author(s)
      Takabayashi F, Sekiguchi H
    • Journal Title

      British journal of Nutririon

      Volume: 110(7) Issue: 7 Pages: 1195-1200

    • DOI

      10.1017/s0007114513000470

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] メチルセルロースとアルギン酸ナトリウムの胃粘膜に対する影響の比較2016

    • Author(s)
      高林ふみ代
    • Organizer
      日本薬学会136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Mucosal thickness and gland mucous cells of mice stomach are increased by continuous administration of high molecular weight methyl cellulose viscous solution efficiently2015

    • Author(s)
      Fumiyo Takabayashi
    • Organizer
      The 6th InternationalConfference of Food Factor
    • Place of Presentation
      Seoul
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous administration of viscous solution of high molecular weight dietary fiber thicken a gastric mucosa of mice efficiently2015

    • Author(s)
      Fumiyo Takabayashi
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yokohama
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Continuous administration of viscous solution of high molecular weight dietary fiber thicken a gastric mucosa of mice efficiently2015

    • Author(s)
      高林ふみ代
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-14 – 2015-05-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 分子量の異なる食物せんい溶液の継続投与による胃粘膜飛行作用の違いについて2015

    • Author(s)
      高林ふみ代
    • Organizer
      日本薬学会135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 分子量の異なるメチルセルロース溶液の継続的経口投与によるマウス胃粘膜への影響2014

    • Author(s)
      高林ふみ代
    • Organizer
      日本フードファクター学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-11-08 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] メチルセルロース溶液の単回投与によるマウス胃粘膜への影響

    • Author(s)
      高林ふみ代
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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