Study on the effects of flavone derivatives on maintenance and enhancement of skeletal muscle
| Project/Area Number |
25350173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | Osaka Prefecture University (2015)
Osaka Women's Junior College (2013-2014) |
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Principal Investigator |
Nakano Yoshihisa 大阪府立大学, 地域連携研究機構, 客員研究員(客員教授) (20081581)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAJI RYOICHI 大阪府立大学, 生命環境科学研究科, 教授 (00244666)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 機能性食品成分 / メトキシフラボン / 骨格筋 / 黒ショウガ / Kaempferia parviflora / 黒ウコン |
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| Outline of Final Research Achievements |
The loss of muscle mass causes decreased mobility and metabolic diseases such as obesity and type 2 diabetes. Therefore, naturally occurring nutraceuticals, which maintain and increase skeletal muscle mass, have emerged as a promising strategy to prevent poor health outcomes as described above. I found that 5-hydroxy-7-methoxyflavones (5-OH-7MFs) from Kaemperia parviflora have enhancing effects on muscle differentiation and myotube size. The intracellular Ca2+ chelator (BAPTA-AM) inhibited the enhancing effects and suppressed 5-OH-7MFs-induced protein synthesis in myotube, suggesting that the intracellular Ca2+ is involved in 5-OH-7MFs-induced hypertrophy. Furthermore, 5-OH-7MFs tended to increase soleus muscle mass in young mice, but significantly increased soleus muscle mass and muscle fiber size in senescence accelerated mice 1 (SAMP1).
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Report
(4 results)
Research Products
(6 results)
