| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
It is widely known that the ingestion of fruit juice is one of the risk factor for developing insulin resistance. In this study, the effects of water insoluble fraction of fruit on postprandial blood glucose level and insulin resistance of normal and type 2 diabetic mice were examined. Postprandial blood glucose level after single oral administration of clear fruit juice not including water insoluble fraction was significantly inhibited in a dose-dependent way by adding water insoluble fraction of fruit. On the other hand, although chronic administration of clear fruit juice did not affect insulin resistance of type 2 diabetic mice, fruit juice including water insoluble fraction ameliorated insulin resistance in a dose-dependently manner. These results suggest that water insoluble fraction of fruit is an important factor for inhibiting postprandial blood glucose elevation and/or preventing insulin resistance.
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