Chrono-nutrition research to improve the circadian disruption-related metabolic disorders
| Project/Area Number |
25350179
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
OISHI Katsutaka 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長 (50338688)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 体内時計 / 食生活 / 肥満 / メタボリックシンドローム / 時計遺伝子 / 機能性食品 / 睡眠 / 時間栄養学 / 骨格筋 / 体温 / 睡眠障害 / 光 / 時間運動学 / 概日リズム / 高脂肪食 / 活動量 |
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| Outline of Final Research Achievements |
Feeding at unusual times of the day (inactive phase) is thought to be associated with obesity and metabolic disorders in experimental animals and in humans. We compared metabolic functions between mice fed only during the sleep phase (daytime) and those fed only during the active phase (nighttime). Feeding during daytime desynchronizes peripheral clocks and causes obesity and metabolic disorders by inducing leptin resistance, hyperphagia, physical inactivity, hepatic fat accumulation and adiposity.
To find natural compounds that could modulate the biological clock, we developed a real-time molecular clock reporter system using neuronal cells derived from PER2::LUC mouse embryos. We discovered that natural compounds such as shikonin, aconitine, alisol A, paeonol, and (E)-cinnamic acid could shorten the circadian period of neuronal clock in vitro.
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Report
(5 results)
Research Products
(89 results)
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[Journal Article] Short-term feeding at the wrong time is sufficient to desynchronize peripheral clocks and induce obesity with hyperphagia, physical inactivity and metabolic disorders in mice2016
Author(s)
Yasumoto Y, Hashimoto C, Nakao R, Yamazaki H, Hiroyama H, Nemoto T, Yamamoto S, Sakurai M, Oike H, Wada N, Yoshida-Noro C, Oishi K
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Journal Title
Metabolism
Volume: 65
Issue: 5
Pages: 714-727
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Wheat alkylresorcinols suppress high-fat, high-sucrose diet-induced obesity and glucose intolerance by increasing insulin sensitivity and cholesterol excretion in male mice2015
Author(s)
Oishi K, Yamamoto S, Itoh N, Nakao R, Yasumoto Y, Tanaka K, Kukuchi Y, Fukudome S, Okita K, Takano-Ishikawa Y
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Journal Title
Journal of Nutrition
Volume: 145
Issue: 2
Pages: 199-206
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 体内時計からみた食と健康2015
Author(s)
大石勝隆
Organizer
第11回北里大学農医連携シンポジウム
Place of Presentation
北里大学白金キャンパス、港区
Year and Date
2015-11-29
Related Report
Invited
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[Presentation] 食と体内時計2014
Author(s)
大石勝隆
Organizer
第6回ISMSJ学術集会 ランチョンセミナー
Place of Presentation
神戸ファッションマート9階イオホール（神戸市）
Year and Date
2014-08-02
Related Report
Invited
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