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Basic study on imaging technique by ultra-low invasive needle

Research Project

Project/Area Number 25350520
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionYamagata University

Principal Investigator

Sato Manabu  山形大学, 理工学研究科, 教授 (50226007)

Co-Investigator(Kenkyū-buntansha) NISHIDATE Izumi  東京農工大学, 大学院研究科, 准教授 (70375319)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords深部生体組織 / 低侵襲性 / 光学イメージング / 断層画像 / 高空間分解能 / フルフィールドOCT / ファイバープローブ / 深部組織 / 深部イメージング / ファイバー / 医用画像 / バイオイメージング
Outline of Final Research Achievements

Using the short multimode fiber(SMMF) with length 8.8mm and diameter 0.125mm made from graded index multimode fiber for optical communications as an imaging probe, basic characteristics such as imaging condition, spatial resolution and wavelength-dependence have been studied theoretically and experimentally, and the reflection images of chicken tendon were measured using 635nm LED as a light source. Further, the SMMF (L:5mm and D:0.125mm) was combined with the full field OCT, and the axial and lateral resolutions were evaluated at 2μm and 4.4μm, respectively. The three dimensional OCT images of dried fin of small fish were measured. The basic technique of an ultrathin low invasive imaging probe has been developed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 4 results) Presentation (15 results)

  • [Journal Article] Imaging characteristics of a 8.8 mm long and 125μm thick graded-index short multimode fiber probe2016

    • Author(s)
      M. Sato, K. Shouji, D. Saito, and I. Nishidate
    • Journal Title

      Appl. Opt.

      Volume: 55 Issue: 12 Pages: 3297-3305

    • DOI

      10.1364/ao.55.003297

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 光コヒーレンストモグラフィーの脳組織活性モニターへの応用研究2015

    • Author(s)
      佐藤 学,西舘 泉
    • Journal Title

      日本レーザー医学会誌

      Volume: 35 Pages: 424-431

    • NAID

      130005152325

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In vivo estimation of light scattering and absorption properties of rat brain using a single-reflectance fiber probe during cortical spreading depression2015

    • Author(s)
      Izumi Nishidate, Chiharu Mizushima, Keiichiro Yoshida, Satoko Kawauchi, Shunichi Sato and Manabu Sato
    • Journal Title

      Journal of Biomedical Optics

      Volume: 20

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Application of Wide-Field Optical Coherence Tomography to Monitoring of Viability of Rat Brain In Vivo2014

    • Author(s)
      Manabu Sato and Izumi Nishidate
    • Journal Title

      OPTICAL REVIEW

      Volume: 21 Pages: 333-338

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] ショートマルチモードファイバープローブを用いたFFOCT による生 体試料観察2016

    • Author(s)
      齋藤 大輔,西舘 泉,佐藤 学
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都、東京工業大学
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 8mm ショートマルチモードファイバーによる生体試料の反射画像測定2016

    • Author(s)
      庄司 光,西舘 泉,佐藤 学
    • Organizer
      第63回応用物理学会春季学術講演会
    • Place of Presentation
      東京都、東京工業大学
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 8mmマルチモードファイバープロープの画像伝送特 性の検討2016

    • Author(s)
      道平晃生,庄司光,齋藤大輔,西舘泉,佐藤学
    • Organizer
      電気学会、光・量子デバイス研究会
    • Place of Presentation
      東京都、東北大学東京分室
    • Year and Date
      2016-03-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショートマルチモードファイバプローブによる反射画像測定Ⅲ2015

    • Author(s)
      庄司光,西舘泉,佐藤学
    • Organizer
      応用物理学会東北支部第70回学術講演会
    • Place of Presentation
      青森県石黒町ホテルアップルランド
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショートマルチフィイバプローブを用いたFFOCTの基礎特性IV2015

    • Author(s)
      齋藤大輔,西舘泉,佐藤学
    • Organizer
      応用物理学会東北支部第70回学術講演会
    • Place of Presentation
      青森県石黒町ホテルアップルランド
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 直径125μm深部イメージング光プローブの基礎検討2015

    • Author(s)
      齋藤大輔,庄司光,西舘泉,佐藤学
    • Organizer
      第16回山形ニューロサイエンス・医工学研究会
    • Place of Presentation
      山形市石黒町ホテルアップルランド
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Full field OCT using short multimode fiber probe2015

    • Author(s)
      M. Sato, Y. Sekine, T. Takahashi, and I.Nishidate
    • Organizer
      5th Asian and Pacific-Rim Symposium on Biophotonics(APBP’15)
    • Place of Presentation
      Pasifico Yokohama,Yokohama, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stability in phase and intensity measurement using quasi single shot wide field optical coherence tomography2015

    • Author(s)
      T. Anna, S. Kimura, D. S. Mehta and M. Sato
    • Organizer
      5th Asian and Pacific-Rim Symposium on Biophotonics(APBP’15)
    • Place of Presentation
      Pasifico Yokohama, Yokohama, Japan
    • Year and Date
      2015-04-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショートマルチモードファイバープローブを用いたFFOCTの基礎特性2015

    • Author(s)
      関根雄樹,高橋俊博,西館泉,佐藤学
    • Organizer
      第62回応用物理学会春季学術講演会
    • Place of Presentation
      神奈川県,東海大学湘南キャンパス
    • Year and Date
      2015-03-11
    • Related Report
      2014 Research-status Report
  • [Presentation] ショートマルチモードファイバーを用いたQF-FF-OCTの基礎特性II2014

    • Author(s)
      関根雄樹,高橋俊博,西舘泉,佐藤学
    • Organizer
      応用物理学会東北支部第69回学術講演会
    • Place of Presentation
      仙台市,東北大学青葉記念会館
    • Year and Date
      2014-12-03
    • Related Report
      2014 Research-status Report
  • [Presentation] ショートマルチモードファイバーを用いたQF-FF-OCTの基本特性2014

    • Author(s)
      関根雄樹, 高橋俊博 , 西舘 泉 ,佐藤学
    • Organizer
      Optics & Photonics Japan 2014
    • Place of Presentation
      東京都,筑波大学東京キャンパス
    • Year and Date
      2014-11-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Basic Research on Nonitoring of Viability of Brain using Wide Field Optical Coherence Tomography2014

    • Author(s)
      Manabu Sato and Izumi Nishidate
    • Organizer
      Collaborative Conference on Materials Research (CCMR) 2014
    • Place of Presentation
      Songdo Convension, Seoul, Korea
    • Year and Date
      2014-06-22 – 2014-06-24
    • Related Report
      2014 Research-status Report
  • [Presentation] ショートマルチファイバー顕微鏡によるラット脳組織の観察2014

    • Author(s)
      関根雄樹,菅野敬浩,石原将太郎,須藤宙,高橋俊博,黒谷玲子,阿部宏之,西館泉,佐藤学
    • Organizer
      山形大学医学部主催
    • Place of Presentation
      山形市,ホテル樹林
    • Year and Date
      2014-06-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Imaging by Tandem Optics using Short Multimode Fiber and GRIN Lens2014

    • Author(s)
      Manabu Sato, Yuuki Sekine, Hiroshi Suto, Takahiro Kanno, Shoutarou Ishihara,Toshihiro Takahashi1, Izumi Nishidate
    • Organizer
      Biomedical Imaging and Sensing Conference’14(BISC’14)
    • Place of Presentation
      Pacifico Yokohama, Yokohama, Japan
    • Year and Date
      2014-04-22 – 2014-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Imaging of rat brain using short graded-index multimode fiber2014

    • Author(s)
      Manabu Sato, Takahiro Kanno, Syoutarou Ishihara, Hiroshi Suto, Toshihiro Takahashi, Reiko Kurotani, Hiroyuki Abe, and Izumi Nishidate
    • Organizer
      BiOS,SPIE
    • Place of Presentation
      Moscone Center, San Francisco(米国)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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