Creation of multi-theranostics nanoparticle for multi-strategic therpnosis
| Project/Area Number |
25350530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Yamaguchi University (2016)
The University of Tokushima (2013-2015) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 有機シリカ粒子 / セラノスティックス / 光線力学療法 / 磁場温熱療法 / 光線温熱療法 / 診断と治療の一体化 / マルチモーダルイメージング / ナノ医療 / セラノスティック / 光線力学的治療 / 磁場温熱治療 |
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| Outline of Final Research Achievements |
We developed novel type of silica nanoparticles, organosilica nanoparticles that are both structurally and functionally different from typical ones and have advantages for multifunctionalization. We have prepared multifunctionalized organosilica nanoparticles for multimodal imaging. In this study we prepared theranostic organosilica nanoparticles enable to combine diagnostics and therapy. We could theranostic organosilica nanoparticles with various pharmacological effects. Multi-theranostic organosilica nanoparticles showed cytotoxic activity on single cell imaging. Improved accumulation of multi-theranostics organosilica nanoparticles in tumor tissue were confirmed using near-infrared in vivo imaging. Furthermore multi-theranostics organosilica nanoparticles revealed therapeutic effects using tumor-bearing mice.
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Report
(5 results)
Research Products
(35 results)
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[Presentation] Effective impairment of myeloma progenitors by hyperthermia: augmentation with bortezomib and Pim inhibition in combination2015
Author(s)
H. Miki, T. Harada, S. Nakamura, H. Tenshin, R. Amachi, K. Watanabe, D. Hanson, J. Teramachi, H. Fujino, K. Sogabe, M. Takahashi, T. Maruhashi, S. Fujii, K. Kagawa, M. Nakamura, T. Matsumoto, M. Abe.
Organizer
15th International Myeloma Workshop
Place of Presentation
Rome, Italy
Year and Date
2015-09-23
Related Report
Int'l Joint Research
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