Development of miniaturized glucose monitoring system by combining a needle-type glucose sensor with intravenous microdialysis sampling method for artificial endocrine pancreas

• Project/Area Number: 25350532
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kumamoto University
• Principal Investigator: SHIMODA SEIYA 熊本大学, 生命科学研究部, 准教授 (60398203)
• Co-Investigator(Kenkyū-buntansha): FURUKAWA NOBORU 熊本大学, 大学院生命科学研究部, 准教授 (90335795) ; ARAKI EIICHI 熊本大学, 大学院生命科学研究部, 教授 (10253733)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 人工臓器工学 / 再生医工学 / 人工膵島 / 連続血糖計測システム

Outline of Final Research Achievements

We developed the glucose monitoring system by combining a need-type glucose sensor with an intravenous microdialysis sampling technique for long-term subcutaneous tissue. This system was tested both in vitro and in vivo. Response time to reach 90% of the final plateau value was calculated by swithching the probe from 100 to 200 mg/dL glucose. The overall correlation between blood glucose measured by this system (X) and blood glucose concentration (Y) was Y = 0.997X + 0.245 (r=0.952). Thus, the new glucose monitoring system developed is potentially suitable for clinical application.

Research Products

• [Journal Article] A 1-year, prospective, observational study of Japanese outpatients with type1 and type 2 diabetes switching from insulin glargine or detemir to insulin degludec in basal-bolus insulin therapy (Kumamoto Insulin Degludec Observational study) (2016)
  • Author(s): Shimoda, S., Sato, M., Sekigami, T., Motoshima, H., Yoshimura, R., Fukuda, K., Matsuo, Y., Noda, H., Okubo, M., Ichimori, S., Fujisawa, K., Fukunaga, M., Araki, E. and Kumamoto Insulin Degludec Observational (KIDUNA) Study Group
  • Journal Title: J Diabetes Investig Volume: in press
  • Peer Reviewed / Open Access
• [Journal Article] Insulin requirement profiles in Japanese hospitalized subjects with type 2 diabetes treated with basal-bolus insulin therapy. (2015)
  • Author(s): Shimoda, S., Okubo, M., Koga, K., Sekigami, T., Kawashima, J., Kukidome, D., Igata, M., Ishii, N., Shimakawa, A., Matsumura, T., Motoshima, H., Furukawa, N., Nishida, K. and Araki, E.
  • Journal Title: Endocr J Volume: 62 Pages: 209-216
  • NAID: 130004704365
  • Peer Reviewed / Open Access