• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Imaging of oxidant stress in brain tumor using an electromagnetic horn type ESR spectrometer including 3D MRI coil with cooling device

Research Project

Project/Area Number 25350534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOita University

Principal Investigator

Kamida Tohru  大分大学, 医学部, 准教授 (90315333)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Tadashi  大分大学, 工学部電気電子工学科, 名誉教授 (30100936)
Ohga Yasushi  大分大学, 工学部応用化学科, 教授 (60252508)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords医用 / 生体画像 / ESR / 電磁ホーン / 脳腫瘍 / イメージング / 冷却装置付きMRIコイル / TMモード共振器 / 脳腫瘍ESRイメージング / 電磁ホーン型ESR装置 / 冷却装置付き3次元MRIコイル / 新規スピンラベル剤 / ファントム試料の画像化
Outline of Final Research Achievements

Imaging of a free radical in the living body is useful at diagnosis of the disease of oxidant stress origin, etc. In order to perform ESR measurement of a living specimen, X-band electromagnetic horn type ESR spectrometer including 3D MRI coil with cooling device capable of measuring both absorption spectrum and dispersion spectrum was developed, and compared with the conventional loop gap resonator in brain tumor model. Although ESR measurement from brain tumor was possible using a nitroxyl radical-labeled methionine for a tracer at the latter, non uniform magnetic field prevented ESR imaging in the former. X-band electromagnetic TM mode ESR spectrometer including 3D MRI coil with cooling device capable of measuring both absorption spectrum and dispersion spectrum was newly designed by application of the above-mentioned equipment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (7 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Comparison of multiple parameters obtained on 3T pulsed arterial spin-labeling, diffusion tensor imaging, and MRS and the Ki-67 labeling index in evaluating glioma grading2015

    • Author(s)
      Fudaba H, Shimomura T, Abe T, Matsuta H, Momii Y, Sugita K, Ooba H, Kamida T, Hikawa T, Fujiki M
    • Journal Title

      Am J Neuroradiol

      Volume: 35(11) Issue: 11 Pages: 2091-2098

    • DOI

      10.3174/ajnr.a4018

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An adult case of cerebral malakoplakia successfully cured by treatment with antibiotics, bethanechol and ascorbic acid2014

    • Author(s)
      Fudaba H, Ooba H, Abe T, Kamida T, Wakabayashi Y, Nagatomi H, Fujiki M
    • Journal Title

      J Neurol Sci

      Volume: 342(1-2) Issue: 1-2 Pages: 192-196

    • DOI

      10.1016/j.jns.2014.05.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Usefulness of pulsed arterial spin-labeling MRI for localizing a seizure focus: a surgical case2014

    • Author(s)
      Sugita K, Kamida T, Matsuta H, Shimomura T, Fujiki M
    • Journal Title

      Seizure

      Volume: 23(4) Issue: 4 Pages: 318-320

    • DOI

      10.1016/j.seizure.2014.01.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The clinical and pathological significance of nitric oxide synthase in human pituitary adenomas: a comparison with MIB-12014

    • Author(s)
      Onishi K, Kamida T, Momii Y, Abe T, Fujiki M
    • Journal Title

      Endocrine

      Volume: 46(1) Issue: 1 Pages: 154-159

    • DOI

      10.1007/s12020-013-0046-4

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cathodal transcranial direct current stimulation affects seizures and cognition in fully amygdala-kindled rats2013

    • Author(s)
      Kamida T, Kong S, Eshima N, Fujiki M
    • Journal Title

      Neurol Res

      Volume: 35(6) Issue: 6 Pages: 602-607

    • DOI

      10.1179/1743132813y.0000000170

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] マウスのけいれん重積モデルにおけるラモトリギンの抗酸化効果2015

    • Author(s)
      上田 徹、松田浩幸、籾井泰朋、杉田憲司、 藤木 稔
    • Organizer
      第49回日本てんかん学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 新規抗てんかん薬ラモトリギンの抗酸化作用について‐マウスのけいれん重積モデルにおける検討‐2015

    • Author(s)
      上田 徹、松田浩幸、籾井泰朋、杉田憲司、 藤木 稔
    • Organizer
      日本脳神経外科学会 第74回学術総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] 言語性ワーキングメモリーにおける側頭葉の役割‐側頭葉てんかんでのfunctinal MRIからの検討2015

    • Author(s)
      松田浩幸、上田 徹、杉田憲司、下村 剛、藤木 稔
    • Organizer
      第38回日本てんかん外科学会
    • Place of Presentation
      都市センターホテル(東京都千代田区)
    • Year and Date
      2015-01-15 – 2015-01-16
    • Related Report
      2014 Research-status Report
  • [Presentation] マウスのけいれん重積モデルにおけるラモトリギンの抗痙攣および抗酸化作用2015

    • Author(s)
      杉田 憲司 上田 徹 松田浩幸  藤木 稔
    • Organizer
      第38回日本てんかん外科学会
    • Place of Presentation
      都市センターホテル(東京都千代田
    • Year and Date
      2015-01-15 – 2015-01-16
    • Related Report
      2014 Research-status Report
  • [Presentation] 非けいれん性てんかん重責状態における1H MRSの意義2014

    • Author(s)
      松田浩之、上田 徹、杉田憲司、内田 晋、札場博貴、下村 剛、藤木 稔
    • Organizer
      第48回日本てんかん学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 皮質形成異常患者における非けいれん性てんかん重積状態の1H MRS2014

    • Author(s)
      杉田憲司、上田 徹、松田浩幸、下村 剛、藤木 稔
    • Organizer
      第37回日本てんかん外科学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] フリーラジカルとてんかん -ラジカルイメージング装置開発への挑戦-2013

    • Author(s)
      上田 徹
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州
    • Related Report
      2013 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] ESRI用造影剤2014

    • Inventor(s)
      小林 正、上田 徹、大賀 恭、籾井泰朋
    • Industrial Property Rights Holder
      国立大学法人 大分大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-11-11
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] 電磁ホーン型ESR試料設置装置2013

    • Inventor(s)
      小林 正,大賀 恭,上田 徹,原 孝文
    • Industrial Property Rights Holder
      国立大学法人 大分大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-21
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi