The effect of iPS cell- and bFGF drug- delivery system on bioabsorbable nerve conduits in peripheral nerve regeneration
| Project/Area Number |
25350537
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Mitsuhiro 大阪市立大学, 大学院医学研究科, 講師 (40309571)
UEMURA Takuya 大阪市立大学, 大学院医学研究科, 病院講師 (10597321)
TAKAMATSU Kiyohito 大阪市立大学, 大学院医学研究科, 客員准教授 (30295688)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | iPS細胞 / 人工神経 / 末梢神経 / 再生医療 / 線維芽細胞増殖因子 / ドラッグデリバリーシステム / 成長因子 / FGF |
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| Outline of Final Research Achievements |
For peripheral nerve repair, various modifications have been explored. Here, sciatic nerve gaps in mice were reconstructed in the following groups: nerve conduit alone (C group), nerve conduit coated with induced pluripotent stem cell (iPSc)-derived neurospheres (I group), nerve conduit coated with iPSc-derived neurospheres and basic fibroblast growth factor (bFGF)-incorporated gelatin microspheres (I+F group), and autograft (A group). The fastest functional recovery and the greatest axon regeneration occurred in the A group, followed in order by the I+F group, I group, and C group until 12 weeks after reconstruction. Thus, peripheral nerve regeneration using nerve conduits and functional recovery in mice were accelerated by a combination of iPSc-derived neurospheres and a bFGF drug delivery system. The combination of all three fundamental methodologies was essential and useful for peripheral nerve regenerative medicine.
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Report
(4 results)
Research Products
(80 results)
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[Journal Article] Characteristics of diabetes associated with poor improvements in clinical outcomes after lumbar spine surgery.2013
Author(s)
Takahashi S, Suzuki A, Toyoda H, Terai H, Dohzono S, Yamada K, Matsumoto T, Yasuda H, Tsukiyama K, Shinohara Y, Ibrahim M, Nakamura H.
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Journal Title
Spine (Phila Pa 1976).
Volume: 38(6)
Pages: 516-522
DOI
NAID
Related Report
Peer Reviewed
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