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Development of an innovative elector-mechanical artificial organ

Research Project

Project/Area Number 25350539
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTokai University

Principal Investigator

Okamoto Eiji  東海大学, 札幌教養教育センター, 教授 (30240633)

Co-Investigator(Renkei-kenkyūsha) MITAMURA YOSHINORI  東海大学, 生物理工学部, 教授 (70002110)
YAMBE TOMOYUKI  東北大学, 加齢医学研究所, 教授 (70241578)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords人工臓器 / 人工心臓 / 再生医療 / 組織工学 / 人体通信 / 補助循環 / 補助人工心臓 / 経皮的情報伝送 / チタンメッシュ / 細胞外マトリックス / 組織誘導 / 軸流ポンプ
Outline of Final Research Achievements

We have developed a new axial flow ventricular assist device that uses organs and tissues as composing elements, and it connects in series with natural heart. We also developed a tissue induced electrode using titanium mesh for the internal communication unit of the new transcutaneous information system using human body as conductive medium. We evaluated them in the animal experiments using goats, and we obtained enough performance to be promising a nest generation a ventricular assist system.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (51 results)

All 2016 2015 2014 2013 Other

All Journal Article (19 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 3 results,  Open Access: 3 results) Presentation (30 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (2 results)

  • [Journal Article] Numerical analysis of the effects of a high gradient magnetic field on flowing erythrocytes in a membrane oxygenator2015

    • Author(s)
      Mitamura Y, Okamoto E
    • Journal Title

      J. Magnetism and Magnetic Materials

      Volume: 380 Pages: 54-60

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Passive magnetic bearing in the 3rd generation miniature axial flow pump-the valvo pump 22015

    • Author(s)
      Okamoto E, Ishida Y, Yano T, Mitamura Y
    • Journal Title

      J.Artificial Organs

      Volume: 18(2) Issue: 2 Pages: 181-184

    • DOI

      10.1007/s10047-014-0806-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart2015

    • Author(s)
      E.Okamoto, T.Yano, Y.Shiraishi, H.Miura, T.Yambe, Y.Mitamura
    • Journal Title

      Artificial Organs

      Volume: 39 Issue: 8 Pages: 701-704

    • DOI

      10.1111/aor.12558

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Histological observation of titanium mesh electrode for transcutaneous information transmission using human body as conductive medium2015

    • Author(s)
      Okamoto E, Shida A,Miura H, Shiraishi Y, Yambe T, Mitamura Y
    • Journal Title

      Proceeding of 54 th annual meeting of Japan Society of Medical and Biological Engineering

      Volume: 54 Pages: 410-412

    • NAID

      130005163638

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 体内植込み用バッテリーと体内―体外間通信の現状と未来2015

    • Author(s)
      )岡本英治
    • Journal Title

      電気学会誌

      Volume: 135(9) Pages: 623-625

    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Journal Article] 循環系へ直列接続される軸流型血液ポンプの数値設計および評価2015

    • Author(s)
      矢野哲也,佐藤陵介,須藤誠一,岡本英治,三田村好矩
    • Journal Title

      日本定常流ポンプ研究会2015抄録集

      Volume: 20 Pages: 16-17

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Measurement of electrode–tissue interface impedance for improvement of a transcutaneous data transmission using human body as transmission medium2014

    • Author(s)
      Okamoto E, Kato Y, Kikuchi S, Mitamura Y
    • Journal Title

      Bio-Medical Materials and Engineering

      Volume: 24 Issue: 4 Pages: 1735-174

    • DOI

      10.3233/bme-140985

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 人工心臓と電池2014

    • Author(s)
      )岡本英治
    • Journal Title

      人工臓器

      Volume: 43 Pages: 82-85

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] 人体通信による人工臓器管理2014

    • Author(s)
      岡本英治,菊池咲子,三田村好矩
    • Journal Title

      第53回日本生体医工学会抄録集CD

      Volume: SY3-04-5 Pages: 1-2

    • NAID

      130004695951

    • Related Report
      2014 Research-status Report
  • [Journal Article] 大動脈装着式軸流型補助人工心臓の基礎開発と現況2014

    • Author(s)
      岡本英治,菊池咲子,三田村好矩
    • Journal Title

      第53回日本生体医工学会抄録集CD

      Volume: OS1-01-4 Pages: 1-2

    • Related Report
      2014 Research-status Report
  • [Journal Article] Numerical analysis of blood flow in the left ventricle partially supported with a continuous flow pump2014

    • Author(s)
      T.Yano,E.Okamoto,Y.Mitamura
    • Journal Title

      第53回日本生体医工学会抄録集CD

      Volume: O3-24-1 Pages: 1-2

    • NAID

      130004948243

    • Related Report
      2014 Research-status Report
  • [Journal Article] 健康寿命延伸に向けた生体組織-電子・機械融合化人工臓器の研究開発2014

    • Author(s)
      岡本英治
    • Journal Title

      平成25年度加齢医学研究拠点共同利用・共同研究報告書

      Volume: H25 Pages: 65-66

    • Related Report
      2014 Research-status Report
    • Open Access
  • [Journal Article] Transcutaneous communication system using the human body as conductive medium:Influence of transmission data current on the heart2013

    • Author(s)
      Eiji Okamoto, Sakiko Kikuchi, Hidekazu Miura, Yasuyuki Shiraishi, Tomoyuki Yambe, Yoshinori Mitamura
    • Journal Title

      J.Bio-Medical Materials and Engineering

      Volume: 23(1-2) Issue: 1-2 Pages: 155-162

    • DOI

      10.3233/bme-120740

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Magnetic Fluid Seal for Rotary Blood Pumps: Behaviors of Magnetic Fluids in a Magnetic Fluid Seal2013

    • Author(s)
      Yoshinori Mitamura
    • Journal Title

      Bio-medical Materials and Engineering

      Volume: 23 Issue: 1-2 Pages: 63-74

    • DOI

      10.3233/bme-120733

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Titanium Mesh Electrode using for Transcutaneous Intrabody Communication by Tissue-Electrode Impedance2013

    • Author(s)
      Eiji Okamoto, Sakiko Kikuchi, Yoshinori Mitamura
    • Journal Title

      Proceeding of 35th Annual International Conference of the IEEE EMBS

      Volume: 35 Pages: 667-670

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Magnetic Fluid Seal for Rotary Blood Pumps: Image and Computational Analyses of Behaviors of Magnetic Fluids2013

    • Author(s)
      Yoshinori Mitamura, Tetsuya Yano, Eiji Okamoto
    • Journal Title

      Proceeding of 35th Annual International Conference of the IEEE EMBS

      Volume: 35 Pages: 663-666

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A magnetic fluid seal for rotary blood pumps: behaviors of magnetic fluids in a magnetic fluid seal with a shield2013

    • Author(s)
      Y Mitamura, T Yano, W Nakamura, E Okamoto
    • Journal Title

      Magnetohydrodynamics

      Volume: 49( 3-4) Pages: 525-529

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血液は磁性流体か?:勾配磁場における血液の流動特性2013

    • Author(s)
      三田村好矩,岡本英治
    • Journal Title

      磁性流体連合講演会講演論文集

      Volume: 11 Pages: 53-56

    • Related Report
      2013 Research-status Report
  • [Journal Article] 非一様磁場における血液の流動特性2013

    • Author(s)
      三田村好矩、岡本 英治
    • Journal Title

      電気学会研究会資料

      Volume: LD-13-087 Pages: 17-24

    • Related Report
      2013 Research-status Report
  • [Presentation] 人体通信を用いた経皮的情報通信システムの開発と体内埋込み通信用電極の評価2016

    • Author(s)
      岡本英治,有村響子,三浦英和,白石泰之 ,山家智之,三田村好矩
    • Organizer
      第44回人工心臓と補助循環懇話会
    • Place of Presentation
      ホテル松島大観荘(宮城県松島町
    • Year and Date
      2016-03-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大動脈内への埋込みを想定した小型軸流血液ポンプValvoPump 2Sのインペラ設計と性能評価2016

    • Author(s)
      矢野 哲也, 佐藤 陵介, 石本 志高,須藤 誠一,岡本 英治, 三田村好矩
    • Organizer
      第28回代用臓器再生医学研究会
    • Place of Presentation
      北大(札幌)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] チタンメッシュを用いた経皮的情報システム用電極の毛細血管分布の検討2016

    • Author(s)
      有村響子,岡本英治,三田村好矩
    • Organizer
      第28回代用臓器再生医学研究会
    • Place of Presentation
      北大(札幌)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軸流型補助人工心臓の下行大動脈装着下補助循環における血行動態の評価2016

    • Author(s)
      岡本英治,矢野哲也,白石泰之,三浦英和,山家智之,三田村好矩
    • Organizer
      第28回代用臓器再生医学研究会
    • Place of Presentation
      北大(札幌)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生体―電子機械を融合する次世代型人工心臓の開発2015

    • Author(s)
      岡本英治
    • Organizer
      医療産業育成支援事業”医療機器等参入支援・産学連携促進セミナー
    • Place of Presentation
      TKP札幌駅カンファレンスセンター(札幌市北区)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 循環系へ直列接続される軸流型血液ポンプの数値設計および評価2015

    • Author(s)
      矢野哲也,佐藤陵介,須藤誠一,岡本英治,三田村好矩
    • Organizer
      日本定常流ポンプ研究会2015
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軸流型補助人工心臓による大動脈直列挿入循環補助における血行動態2015

    • Author(s)
      岡本英治,矢野哲也,白石泰之,三浦英和,山家智之,三田村好矩
    • Organizer
      第53回日本人工臓器学会大会
    • Place of Presentation
      東京ドームホテル(東京都文京区)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大動脈装着式軸流型ポンプの開発と工学的課題2015

    • Author(s)
      岡本英治,矢野哲也,三浦英和,白石泰之,山家智之,三田村好矩
    • Organizer
      日本生体医工学会専門別研究会医用アクチュエーション研究会
    • Place of Presentation
      北海道大学(札幌市北区)
    • Year and Date
      2015-09-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Electrical and Histological Evaluation of Titanium Mesh as Electrode for Transcutaneous Communication System of Implantable Artificial Hearts2015

    • Author(s)
      Okamoto E, Shida A, Miura H, Shiraishi Y, Yambe T, Mitamura Y,
    • Organizer
      The 61th annual conference of American Society of Artificial Internal Organs in conjunction with the Internal Federation of Artificial Organs
    • Place of Presentation
      Chcago,USA
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] チタンメッシュを用いた経皮情報システム用組織誘導電型電極の組織学的検討2015

    • Author(s)
      岡本英治,志田茜,三浦英和,白石泰之,山家智之,三田村好矩
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議議場(名古屋市熱田区)
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血液ポンプ流れの数値解析2015

    • Author(s)
      矢野哲也,須藤誠一,岡本英治,三田村好矩
    • Organizer
      第54回日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議議場(名古屋市熱田区)
    • Year and Date
      2015-05-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 胸腔内壁に装着したチタンメッシュ電極の組織学的評価2015

    • Author(s)
      岡本英治,志田茜,三浦英和,白石泰之,山家智之,三田村好矩
    • Organizer
      第27回代用臓器再生医学研究会
    • Place of Presentation
      北大医学部学友会館フラテ(札幌市北区)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 在宅医療とネットIT利用2014

    • Author(s)
      岡本英治
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      札幌京王プラザホテル(札幌市中央区)
    • Year and Date
      2014-10-19
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] チタンメッシュを用いた経皮的情報通信用組織誘導電極のin vivo 性能評価2014

    • Author(s)
      岡本英治,志田茜,三浦英和,白石泰之,山家智之,三田村好矩
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      札幌京王プラザホテル(札幌市中央区)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 大動脈挿入A-Aバイパス式軸流型補助人工心臓の急性動物実験評価2014

    • Author(s)
      岡本英治,矢野哲也,三浦英和,白石泰之,山家智之,三田村好矩
    • Organizer
      第52回日本人工臓器学会大会
    • Place of Presentation
      札幌京王プラザホテル(札幌市中央区)
    • Year and Date
      2014-10-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Initial acute animal experiment of the new miniature axial flow pump as arterio-arterial pumping2014

    • Author(s)
      Eiji Okamoto, Tetsuya Yano, Yasuyuki Shiraishi, Hidekazu Miura, Tomoyuki Yambe, Yoshinori Mitamura
    • Organizer
      22nd Annual Congress of the International Society of Rotary Blood Pump
    • Place of Presentation
      Hotel Nikko Sanfrancisco(Sanfrancisco,USA)
    • Year and Date
      2014-09-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 人体通信による人工臓器管理2014

    • Author(s)
      岡本英治,菊池咲子,三田村好矩
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 連続流血液ポンプによる部分補助下の心室内血流解析2014

    • Author(s)
      矢野哲也,須藤誠一,岡本英治,三田村好矩
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 大動脈装着式軸流型補助人工心臓の基礎開発と現状2014

    • Author(s)
      岡本英治,矢野哲也,石田裕也,三田村好矩
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2014-06-24
    • Related Report
      2014 Research-status Report
  • [Presentation] A new axial flow pump install the base of ascending aorta: initial report of development of the VALVO PUMPII2013

    • Author(s)
      Eiji Okamoto,Akira Kuzumi, Yuya Ishida, Tetsuya Yano, Sakiko Kikuchi, Yoshinori Mitamura
    • Organizer
      59th annual conference of American Society of Internal Artificial Organs
    • Place of Presentation
      Fairmont Chicago(Chicago,USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Evaluation of Titanium Mesh Electrode using for Transcutaneous Intrabody Communication by Tissue-Electrode Impedance2013

    • Author(s)
      Eiji Okamoto,Sakiko Kikuchi, Yoshinori Mitamura
    • Organizer
      35th annual international conference of IEEE Engineering in Medicine and Biology society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] A Magnetic Fluid Seal for Rotary Blood Pumps: Image and Computational Analyses of Behaviors of Magnetic Fluids2013

    • Author(s)
      Yoshinori Mitamura, Tetsuya Yano, Eiji Okamoto
    • Organizer
      35th annual international conference of IEEE Engineering in Medicine and Biology society
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of a new axial flow pump Valvo Pump II toward a compact third generation blood pump2013

    • Author(s)
      Eiji Okamoto, Yuya Ishida, Tetsuya Yano, Sakiko Kikuchi, Yoshinori Mitamura
    • Organizer
      21st Congress of the International Society for Rotary Blood Pumps
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Titanium Mesh Electrode for Transcutaneous Communication System Using Human Body as Conductive Medium2013

    • Author(s)
      Sakiko Kikuchi, Eiji Okamoto,Yuya Ishida,Kasumi Okabe, Yuki Kamebuchi, Yoshinori Mitamura
    • Organizer
      Joint International Congress of 5th congress of the international federation for artificial hearts, and 51th annual meeting of the Japanese society of artificial organs
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 大動脈基部装着型軸流式補助人工心臓用軸受の性能評価2013

    • Author(s)
      石田裕也,岡本英治,矢野哲也,菊池咲子,三田村好矩
    • Organizer
      第51回日本人工臓器学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 経皮的情報通信システムにおける体内埋込み用生体組織誘導型電極の性能評価

    • Author(s)
      菊池咲子,岡本英治,岡部香澄,亀渕友紀,石田裕也,三田村好矩
    • Organizer
      第52回日本生体医工学会北海道支部大会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 再生医療時代の人工心臓―人工心臓における生体組織応用-

    • Author(s)
      岡本英治
    • Organizer
      電気学会リニアドライブ研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 非一様磁場における血液の流動特性

    • Author(s)
      三田村好矩,岡本英治
    • Organizer
      電気学会リニアドライブ研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] チタンメッシュ電極の電極インピーダンスのin vivo測定と性能評価

    • Author(s)
      菊地咲子,岡本英治,岡部香澄,亀渕友紀,石田裕也,三田村好矩
    • Organizer
      第26回代用臓器再生医学研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 連続流型補助人工心臓による部分補助下における左室内血流動態の数値流体解析

    • Author(s)
      矢野哲也,須藤誠一,岡本英治,三田村好矩
    • Organizer
      第26回代用臓器再生医学研究会
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Related Report
      2013 Research-status Report
  • [Remarks] 東海大学札幌キャンパス・人工臓器・再生医療研究室

    • URL

      http://artificialorgans.web.fc2.com/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東海大学札幌キャンパス人工臓器・再生医療研究室

    • URL

      http://artificialorgans.web.fc2.com/

    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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