| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Copolymers of 3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate and poly(ethylene glycol) methacrylate were prepared to develop cancer thermochemotherapy. Among these polymers, the random copolymers formed nanospheres self-assembly in physiological solution conditions. Moreover, the random polymers exhibited little cytotoxicity and effective cellular uptake based on membrane translocation as the main pathway of internalization. The polymer was effectively internalized into cells even after conjugation with doxorubicine, a cancer drug. The conjugated polymer exhibited the cell killing activity without reducing the drug efficacy and induced apoptosis of cancer cells.
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