RAFT Miniemulsion Polymerization using Oligosaccharide-Conjugated CTA Producing Antithrombogenic Polymeric Coating Agent
| Project/Area Number |
25350550
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Yamagata University |
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Principal Investigator |
Narumi Atsushi 山形大学, 理工学研究科, 准教授 (60443975)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖鎖修飾CTA / RAFT重合 / ミニエマルション重合 / グリコポリマー / ブロックコポリマー / ポリマー微粒子 / 植物資源高度活用 / 生体適合性 / 糖鎖修飾ポリマー / バイオコンジュゲート / 末端修飾ポリマー / 両親媒性ポリマー / ナノ相分離構造 / 糖 / リビングラジカル重合 / 高分子ミセル / 相分離 |
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| Outline of Final Research Achievements |
We have conducted this research to develop polymer coating agents constructing material surfaces showing antithrombogenicity. As a raw material for such polymeric agents, we have focused on the use of end-functionalized vinyl polymers with plant-derived oligosaccharides. A method to prepare end-glycosylated polymers with well-defined structures in water has been developed in this study. Film-formation experiments by casting the solution of the end-glycosylated polymers on the silicone substrate and protein adhesion tests on the film-surface were demonstrated, suggesting that the polymer synthesized in this study has a potential as being applicable to polymeric agents providing material surfaces showing antithrombogenicity.
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Report
(4 results)
Research Products
(11 results)
