Design of polypeptide showing UCST-type phase transition behavior
| Project/Area Number |
25350552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
Shimada Naohiko 東京工業大学, 生命理工学研究科, 助教 (10423972)
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| Co-Investigator(Renkei-kenkyūsha) |
Atsushi Maruyama 東京工業大学, 生命理工学研究科, 教授 (40190566)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | UCST / ペプチド / 温度応答性高分子 / ポリペプチド / 生分解 |
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| Outline of Final Research Achievements |
There are many polymers showing LCST-type phase transition behavior under physiological conditions. However, there is few polymers showing UCST-type phase transition behavior under the conditons. We have reported that poly citrulline polypeptide showed UCST-type behavior. In this study, we estimated effect of optical activity of the polypeptide on UCST-type solution behavior. CD spectra indicated that the polypeptide adopted a-helix conformation and form a bundle structure below phase separation temperature.
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Report
(4 results)
Research Products
(15 results)
