Development of antibacterial material with reducing cytotoxicity
| Project/Area Number |
25350557
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Yoshinao 近畿大学, 生物理工学部, 准教授 (90333509)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ナノ材料 / ハイドロキシアパタイト / 銀 / 抗菌性 / 分散性 |
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| Outline of Final Research Achievements |
Our objective of the project is the development of antibacterial novel nanomaterial with weak cytotoxicity. Synthesis of Ag-doped hydroxyapatite (HAp) nanoparticles with highly dispersibility and crystallinity, examination of coating property, evaluations of material and biological properties were conducted. The highly dispersible Ag-HAp nanoparticles by using the anti-sintering method were prepared. The functionality for nano-coating on polymer substrates was well-satisfied. Antibacterial activities for E. coli. and P. aeruginosa were observed. In cell-adhesion test, human epithelial type 2 cells were well-adhered on the Ag-HAp coating sheet as same as cell culture dish. Thus, the antibacterial Ag-HAp nanoparticles as a coating nanomaterial on medical devices with reducing cytotoxicity have been successively developed.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Complete genomic DNA sequence of the East Asian spotted fever disease agent Rickettsia japonica2013
Author(s)
2. Matsutani M, Ogawa M, Takaoka N, Hanaoka N, Toh H, Yamashita A, Oshima K, Hirakawa H, Kuhara S, Suzuki H, Hattori M, Kishimoto T, Ando S, Azuma Y, Shirai M.
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Journal Title
PLoS One
Volume: 8
Issue: 9
Pages: e71861-e71861
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] 遺伝子導入による耐熱化2014
Author(s)
東 慶直
Organizer
ALCAサイトビジット講演会
Place of Presentation
山口大学工学部（山口県宇部市）
Year and Date
2014-06-01
Related Report
Invited
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