| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
Our objective of the project is the development of antibacterial novel nanomaterial with weak cytotoxicity. Synthesis of Ag-doped hydroxyapatite (HAp) nanoparticles with highly dispersibility and crystallinity, examination of coating property, evaluations of material and biological properties were conducted. The highly dispersible Ag-HAp nanoparticles by using the anti-sintering method were prepared. The functionality for nano-coating on polymer substrates was well-satisfied. Antibacterial activities for E. coli. and P. aeruginosa were observed. In cell-adhesion test, human epithelial type 2 cells were well-adhered on the Ag-HAp coating sheet as same as cell culture dish. Thus, the antibacterial Ag-HAp nanoparticles as a coating nanomaterial on medical devices with reducing cytotoxicity have been successively developed.
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