Preliminary study of urinary L-FABP as early diagnostic biomarker for renal allograft injury.

• Project/Area Number: 25350559
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: Iwate University
• Principal Investigator: Katayama Masaaki 岩手大学, 農学部, 准教授 (70436054)
• Co-Investigator(Kenkyū-buntansha): MIYAZAKI Masao 岩手大学, 農学部, 准教授 (20392144)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 腎移植 / 虚血再灌流傷害 / L-FABP / ネコ / 急性拒絶反応 / 猫 / 腎臓 / GFR

Outline of Final Research Achievements

Expression of the L-typed fatty acid binding protein (L-FABP) was confirmed in feline kidney tissue, especially within renal tubular cells, as well as human. In feline kidney tissue samples, expression of L-FABP was not significantly related to the kidney function.
In kidney ischemia/reperfusion injury and acute kidney rejection models, L-FABP was appeared in tubular cavities before the increase of serum creatinine. L-FABP may play a role as a biomarker for predicting impairment of renal function rather than for expressing kidney damages.