| Project/Area Number |
25350566
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Osaka University |
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Principal Investigator |
Nakajima Kiyokazu 大阪大学, 国際医工情報センター, 特任教授(常勤) (30432537)
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| Co-Investigator(Kenkyū-buntansha) |
山崎 誠 大阪大学, 医学(系)研究科(研究院), 講師 (50444518)
高橋 剛 大阪大学, 医学(系)研究科(研究院), 助教 (50452389)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内視鏡外科学 / 消化器内視鏡学 / 上部消化管学 / 実験外科学 / 胃十二指腸外科学 / 定圧自動送気内視鏡SPACE / 手動送気装置 |
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| Outline of Final Research Achievements |
The purpose of this study was to improve insufflation technique to disseminate highly challenging endoscopic intervention e.g. endoscopic submucosal dissection (ESD), as safer and more standardized treatment. The study was conducted in stepwise manner, from basic to semi-clinical settings. An intentional gastric perforation was created in porcine models, to compare pressure dynamics between automatically insufflated group (group A) and blindly (manually) insufflated group (group B). The results were as follows:
1)In forceful insufflation animals, both gastric and intra-abdominal pressures were well controlled within preset range in group A, whereas excessively elevated in group B. 2)In clip closure models, both pressures were again within acceptable range in group A. The intra-abdominal pressure, however, was significantly elevated beyond preset range in group B. 3)In semi-clinical settings, the intra-abdominal pressure was significantly elevated in group B.
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