| Project/Area Number |
25350567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
千田 彰一 香川大学, 医学部, 名誉教授 (30145049)
岡田 宏基 香川大学, 医学部, 教授 (00243775)
清水 裕子 香川大学, 医学部, 教授 (10360314)
合田 文則 香川大学, 医学部附属病院, 准教授 (90294769)
樋本 尚志 香川県立保健医療大学, 保健医療学部, 教授 (20325343)
犬飼 道雄 香川大学, 医学部附属病院, 助教 (60572667)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生活習慣病 / 老化 / 臓器障害 / 高血圧 / 精神的ストレス / 超音波 / 動脈硬化 / 老化指標 |
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| Outline of Final Research Achievements |
Weinvestigate the association between plasma brain natriuretic peptide (BNP) levels and systolic blood pressure (SBP) variability over a one-year period. Blood pressure was measured in patients treated for hypertension at an outpatient clinic every one to two months over a one-year period. The standard deviation (SD) and the coefficient of variation (CV) were calculated to assess SBP variability. Mean SBP was also calculated over the year. Plasma BNP levels were measured at the end of the one-year period. BNP was found to correlate with mean SBP (r=0.599; P<0.001). However, BNP was not observed to be correlate with either the SD or the CV of the SBP. Multiple regression analysis revealed that only the mean values of SBP were independently associated with BNP (β=0.613; P<0.001). Plasma BNP levels may reflect the average SBP, but not SBP variability over the one-year period prior to the measurement of BNP in patients with hypertension.
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