| Project/Area Number |
25350612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Louis Pasteur Center for Medical Research |
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Principal Investigator |
Kokura Satoshi 公益財団法人ルイ・パストゥール医学研究センター, 免疫学研究室, 研究員 (80347442)
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| Co-Investigator(Kenkyū-buntansha) |
石川 剛 京都府立医大, 消化器内科, 講師 (90372846)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイパーサーミア / 癌免疫 / 制御性Tリンパ球 / 免疫逃避機構 / NK細胞 / 樹状細胞 / MHC-classI / 免疫機構 / ナイーブT細胞 / TGFーB / IL-10 / VEGF / Treg / EMT / E-cadherin / vimentin / 免疫監視機構 / 免疫抑制 / 温熱療法 / 免疫細胞療法 / 免疫監視機構の逃避 |
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| Outline of Final Research Achievements |
Hyperthermia activates the host immune system against cancer whereas the overall mechanisms are yet to be fully elucidated. So far, several mechanisms of anti-cancer activity by hyperthermia have been postulated : increasing cytotoxicity of effector cells such as NK cells against cancer : enhancing maturation of immature DCs via the production of the HSP-tumor antigen complex in tumors : decreasing the numbers of Tregs in tumor tissues and blood; increasing the expression levels of adhesion molecules in cancer cells. Better uses of hyperthermia will be achieved by further understanding of its effects on the immune system. Additionally, clinical data on cancer treatments using hyperthermia in combination with immunotherapy need to be accumulated and evaluated for their respective clinical efficacies. These efforts will lead to the development of efficient combinatory therapies using immune therapy.
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