| Project/Area Number |
25350615
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
Kato Hiroyuki 国際医療福祉大学, 大学病院, 教授 (60224531)
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| Research Collaborator |
HASHIMOTO RITSUO 国際医療福祉大学, 大学病院, 教授 (50254917)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脳卒中 / リハビリテーション / 片麻痺 / ファンクショナルMRI / トラクトグラフィー / functional MRI / 脳梗塞 |
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| Outline of Final Research Achievements |
The aim of this study was to clarify the relation between post-stroke motor reorganization of the brain and the structure of the pyramidal tract. We performed both fMRI using a hand movement task and tractography of the pyramidal tract in 16 patients with mildly hemiparetic stroke. fMRI brain activities were normal or reduced when the pyramidal tract was preserved, but were reorganized in nearly a half of the studies when the pyramidal tract was damaged. The pyramidal tract was normal in 12 studies: fMRI activation was normal in 6 and reduced in 3 after 3-13 days of stroke onset, and was normal in 2 and reduced in 1 after 1-12 months. The pyramidal tract was damaged in 7 studies: fMRI activation was normal in 2, reduced in 1 and reorganized in 1 after 4-14 days of stroke onset, and was normal in 1 and reorganized in 2 after 1-5 months. The findings suggest that damage to the pyramidal tract leads to post-stroke reorganization of brain motor network.
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