Dual dimension facilitation of brain function utilizing neuroimaging

• Project/Area Number: 25350627
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nippon Medical School
• Principal Investigator: Hara Yukihiro 日本医科大学, 医学(系)研究科(研究院), 教授 (20198899)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 脳機能 / 機能改善 / ニューロリハビリテーション / 機能的電気刺激 / ニューロデュレーション / ニューロモデュレーション

Outline of Final Research Achievements

The aim of this study was to investigate the dual effects with EMG-controlled functional electrical stimulation (EMG-FES) and transcranial direct current stimulation (t-DCS) on upper extremity function and brain perfusion among stroke patients.The subjects were 16 chronic stroke patients with moderate impaired hemiparesis. They had anodal or cathodal t-DCS to C3 or C4 in international 10-20 system for 20 minutes. Subjects had 60 minutes EMG-FES therapy followed with 20 minutes anodal t-DCS neuromodulation every day for continuous ten days. Anodal t-DCS and EMG-FES induced the functional improvement and increase of the brain perfusion at affected sensory motor cortex (SMC) in NIRS in 11 patients. The sensory motor integration due to EMG-FES and global brain activation of t-DCS might facilitate the perfusion of SMC and resulted in the functional improvement of hemiparetic upper extremity.

Research Products

• [Journal Article] Effect of Dual Therapy with Botulinum Toxin A Injection and Electromyography-controlled Functional Electrical Stimulation on Active Function in the Spastic Paretic Hand (2016)
  • Author(s): Tsuchiya M, Morita A, Hara Y
  • Journal Title: Journal of Nippon Medical School Volume: 83 Issue: 1 Pages: 15-23
  • DOI: 10.1272/jnms.83.15
  • NAID: 130005132786
  • ISSN: 1345-4676, 1347-3409
  • Peer Reviewed
• [Journal Article] Brain Plasticity and Rehabilitation in Stroke Patients (2015)
  • Author(s): Hara Yukihiro
  • Journal Title: Journal of Nippon Medical School Volume: 82 Issue: 1 Pages: 4-13
  • DOI: 10.1272/jnms.82.4
  • NAID: 130004926737
  • ISSN: 1345-4676, 1347-3409
  • Peer Reviewed
• [Journal Article] 運動誘発型機能的電気刺激(IVES)と脳神経機能的再構築 (2015)
  • Author(s): 原 行弘
  • Journal Title: Jpn J Rehabil Med Volume: 52 Pages: 323-326
  • Peer Reviewed
• [Journal Article] Reply to "The effects of functional electrical stimulation on upper extremity function and cortical plasticity in chronic stroke patients" (2014)
  • Author(s): Hara Yukihiro
  • Journal Title: Clin Neurophysiol Volume: Supplement Issue: 8 Pages: 1710-1711
  • DOI: 10.1016/j.clinph.2013.12.106
  • Peer Reviewed
• [Journal Article] The effects of electromyography-controlled functional electrical stimulation therapy on hemiparetic upper extremity function and cortical perfusion in chronic stroke patients. (2013)
  • Author(s): Hara Yukihiro, et al
  • Journal Title: Clin Neurophysiol Volume: 124 Issue: 10 Pages: 2008-2015
  • DOI: 10.1016/j.clinph.2013.03.030
  • Peer Reviewed
• [Journal Article] Rehabilitation with functional electrical stimulation in stroke patients (2013)
  • Author(s): Hara Yukihiro
  • Journal Title: Int J Phys Med Rehabil Volume: 1 Issue: 06 Pages: 6-6
  • DOI: 10.4172/2329-9096.1000147
  • Peer Reviewed
• [Journal Article] Modulation of cortical vestibular processing by somatosensory inputs in the posterior insula. (2013)
  • Author(s): Hashimoto T, Taoka M, Obayashi S, Hara Y, Tanaka M, Iriki A
  • Journal Title: Brain Inj Volume: 27 Issue: 13-14 Pages: 1685-1691
  • DOI: 10.3109/02699052.2013.831128
  • Peer Reviewed
• [Presentation] 脳の可塑性とリハビリテーション (2015)
  • Author(s): 原 行弘
  • Organizer: 第45回日本臨床神経生理学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] Brain plasticity induced by the electromyography-controlled functional electrical stimulation – Near-infrared spectroscopy (NIRS) study - (2015)
  • Author(s): Hara Yukihiro
  • Organizer: 9TH WORLD CONGRESS OF THE INTERNATIONAL SOCIETY OF PHYSICAL AND REHABILITATION MEDICINE
  • Place of Presentation: Berline
  • Year and Date: 2015-06-19
  • Int'l Joint Research
• [Presentation] Dual effects with functional electrical stimulation (FES) and neuromodulation on the brain cortical perfusion among strokes. (2014)
  • Author(s): Hara Y, Fuseya H, Obayashi S, Tujiuchi K
  • Organizer: 4th Asia-Oceania Conference of Physical & Rehabilitation Medicine.
  • Place of Presentation: Bangkok
  • Year and Date: 2014-12-12
• [Presentation] ボツリヌス毒素注射と機能的電気刺激による上肢痙性麻痺巧緻運動障害への効果. (2014)
  • Author(s): 原 行弘、妹尾麻代、伏屋洋志、大林茂、伏屋洋志、大林茂妹尾麻代
  • Organizer: 第44回日本臨床神経生理学会学術集会、、
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-14
• [Presentation] シンポジウム：脳卒中リハビリテーションの新機器/運動誘発型機能的電気刺激(IVES)と脳神経機能的再構築. (2014)
  • Author(s): 原 行弘
  • Organizer: 第51回日本リハビリテーション医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-06-06
  • Invited
• [Presentation] Dual effects with Power-assisted functional electrical stimulation and t-DCS on the brain cortical perfusion among strokes (2014)
  • Author(s): Yukihiro Hara, Shigeru Obayashi, Kazuto Tujiuchi, Hiroshi Fuseya
  • Organizer: ICCN 30th
  • Place of Presentation: Berlin
• [Presentation] 機能的電気刺激(FES)と経頭蓋直流電流刺激併用による運動野への影響 (2013)
  • Author(s): 原 行弘
  • Organizer: 第43回日本臨床神経生理学会学術集会
  • Place of Presentation: 東京
• [Presentation] Dual effects with Power-assisted functional electrical stimulation and t-DCS on the brain cortical perfusion among strokes (2013)
  • Author(s): Yukihiro Hara, Shigeru Obayashi, Kazuto Tujiuchi, Hiroshi Fuseya
  • Organizer: IRMA 7th
  • Place of Presentation: Beijin
• [Book] パワーアシスト・ロボットに関する材料,電子機器,制御と実用化,その最新技術 (2015)
  • Author(s): 原 行弘
  • Total Pages: 590
  • Publisher: 技術情報協会
• [Book] 神経内科研修ノート (2015)
  • Author(s): 原 行弘
  • Total Pages: 736
  • Publisher: 診断と治療社