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Induction of plastic changes of motor related cortices by dual-hemisphere transcranial direct current stimulation

Research Project

Project/Area Number 25350631
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionNiigata University of Health and Welfare

Principal Investigator

KIRMOTO HIKARI  新潟医療福祉大学, 医療技術学部, 教授 (40406260)

Co-Investigator(Kenkyū-buntansha) SUZUKI Makoto  北里大学, 医療衛生学部, 教授 (80554302)
Co-Investigator(Renkei-kenkyūsha) TAMAKI Hiroyuki  新潟医療福祉大学, 医療技術学部, 教授 (40253926)
ONISHI Hideaki  新潟医療福祉大学, 医療技術学部, 教授 (90339953)
TOBIMATSU Shozo  九州大学, 医学研究科, 教授 (40164008)
OGATA Katsuya  九州大学, 医学研究科, 助教 (50380613)
Research Collaborator KOJIMA Sho  新潟医療福祉大学, 大学院医療福祉学専攻
MIAGUCHI Shota  新潟医療福祉大学, 大学院医療福祉学専攻
MATSUMOTO Takuya  新潟医療福祉大学, 大学院医療福祉学専攻
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords経頭蓋直流電流刺激 / 経頭蓋静磁場刺激 / 一次運動野 / 一次体性感覚野 / 巧緻動作 / 運動誘発電位 / 体性感覚誘発電位 / 経頭蓋直流電流刺激(tDCS) / 可塑性 / 経頭蓋磁気刺激(TMS)
Outline of Final Research Achievements

For transcranial direct current stimulation (tDCS) stimulation, electrodes are applied and secured to the scalp over the desired areas, and currents are delivered to the underlying cortical tissue. We demonstrated that Dual-tDCS (with the anodal electrode over the M1 and the cathodal electrode over the contralateral M1) enhanced cortical excitability that induced the increased amplitude of motor evoked potentials. On the other hand, Uni-tDCS (with the cathodal electrode over the contralateral orbit) was suited to improve the accuracy of visual tracking upper limb movement, compared with Dual-tDCS.
In addition, we showed that 10 min of transcranial static magnetic field stimulation (tSMS) using a powerful cylindrical neodymium, iron and boron (NdFeB) magnet can reduce the amplitude of somatosensory evoked potentials for a few minutes after magnet removal. tSMS has the potential for becoming a new non-invasive brain stimulation tool to modulate cerebral excitability.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (38 results)

All 2016 2015 2014 2013

All Journal Article (23 results) (of which Acknowledgement Compliant: 15 results,  Peer Reviewed: 22 results,  Open Access: 6 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Transcranial static magnetic field stimulation - new non-invasive brain stimulation tool2016

    • Author(s)
      Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: in publishing

    • NAID

      130005165310

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Do differences in levels, types, and duration of muscle contraction have an effect on the degree of post-exercise depression?2016

    • Author(s)
      Miyaguchi S, Kojima S, Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      Frontiers in human neuroscience

      Volume: doi Pages: 1-9

    • DOI

      10.3389/fnhum.2016.00159

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of range and angular velocity of passive movement on somatosensory evoked magnetic fields2016

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kotan S, Kirimoto H, Tsubaki A, Tamaki H, Shirozu H, Kameyama S
    • Journal Title

      Brain Topography

      Volume: in publishing

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Modulation of Cortical Inhibitory Circuits after Cathodal Transcranial Direct Current Stimulation over the Primary Motor Cortex2016

    • Author(s)
      Sasaki R, Miyaguchi S, Kotan S, Kojima S, Kirimoto H, Onishi H
    • Journal Title

      Frontiers in human neuroscience

      Volume: doi Pages: 1-8

    • DOI

      10.3389/fnhum.2016.00030

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Plasticity of human motor associate and primary sensorimotor cortices induced by tDCS2015

    • Author(s)
      Kirimoto H, Miyaguchi S, TamakiH, Suzuki M, Sugawara K, Matsumoto T, Onishi H
    • Journal Title

      Advances in Exercise and Sports Physiology

      Volume: 21(3) Pages: 47-52

    • NAID

      110010022637

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 経頭蓋直流電流刺激の効果的な介入方法の検討-電極貼付部位および電流強度の影響-2015

    • Author(s)
      宮口翔太,大西秀明,小島翔,菅原和広桐本光,田巻弘之,山本智章
    • Journal Title

      理学療法学

      Volume: 42(3) Pages: 213-219

    • NAID

      110009970961

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] キーボードでの単語入力課題が同側一次運動野の皮質内抑制機能に及ぼす影響2015

    • Author(s)
      松本卓也,桐本光,宮口翔太,大西秀明,田巻弘之
    • Journal Title

      臨床神経生理学

      Volume: 43(2) Pages: 70-78

    • NAID

      130005150164

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of cathodal transcranial direct current stimulation to primary somatosensory cortex on short-latency afferent inhibition2015

    • Author(s)
      Kojima S, Onishi H, Miyaguchi S, Kotan S, Sugawara K, Kirimoto H, Tamaki H
    • Journal Title

      Neuroreport

      Volume: 26(11) Issue: 11 Pages: 634-637

    • DOI

      10.1097/wnr.0000000000000402

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of electrical stimulation-induced muscle force and streptomycin treatment on muscle and trabecular bone mass in early-stage disuse musculoskeletal atrophy2015

    • Author(s)
      Tamaki H, Yotani K, Ogita F, Sugawara K, Kirimoto H, Onishi H, Kasuga N, Yamamoto N
    • Journal Title

      Journal of Musculoskeletal & Neuronal Interactions

      Volume: 15(3) Pages: 270-278

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The effect of anodal transcranial direct current stimulation over the primary motor or somatosensory cortices on somatosensory evoked magnetic fields2015

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kojima S, Miyaguchi S, Kirimoto H, Tsubaki A, Tamaki H, Shirozu H, Kameyama S
    • Journal Title

      Clinical Neurophysiology

      Volume: 126(1) Issue: 1 Pages: 60-67

    • DOI

      10.1016/j.clinph.2014.04.014

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Time course of change in movement structure during learning of goal-directed movement2015

    • Author(s)
      Suzuki M, Kirimoto H, Sugawara K, Kasahara Y, Kawaguchi T, Ishizaka I, Yamada S, Matsunaga A, Fukuda M, Onishi H
    • Journal Title

      Journal of Medical and Biological Engineering

      Volume: 35(1) Issue: 1 Pages: 113-124

    • DOI

      10.1007/s40846-015-0012-0

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasticity of human motor associate and primary sensorimotor cortices induced by tDCS2015

    • Author(s)
      Kirimoto H, Miyaguchi S, Tamaki H, Suzuki M, Sugawara K, Matsumoto T, Onishi H.
    • Journal Title

      Advances in Exercise and Sports Physiology

      Volume: 未定

    • NAID

      110010022637

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sensorimotor Modulation Differs with Load Type during Constant Finger Force or Position2014

    • Author(s)
      Kirimoto H, Tamaki H, Suzuki M, Matsumoto T, Sugawara K, Kojima S, Onishi H
    • Journal Title

      PloS one

      Volume: 9 Issue: 9 Pages: e108058-e108058

    • DOI

      10.1371/journal.pone.0108058

    • NAID

      120006800810

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of Transcranial Static Magnetic Field Stimulation Over the Sensorimotor Cortex on Somatosensory Evoked Potentials in Humans2014

    • Author(s)
      Kirimoto H, Tamaki H, Matsumoto T, Suzuki M, Sugawara K, Oyama M, Onishi H.
    • Journal Title

      Brain stimulation

      Volume: 7 Issue: 6 Pages: 836-840

    • DOI

      10.1016/j.brs.2014.09.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The modulatory effect of electrical stimulation on the excitability of the corticospinal tract varies according to the type of muscle contraction being performed2014

    • Author(s)
      Saito K, Sugawara K, Miyaguchi S, Matsumoto T, Kirimoto H, Tamaki H, Onishi H
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 8

    • DOI

      10.3389/fnhum.2014.00835

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Repeated practice of a Go/NoGo visuomotor task induces neuroplastic change in the human posterior parietal cortex: an MEG study.2013

    • Author(s)
      Sugawara K, Onishi H, et al
    • Journal Title

      Exp Brain Research

      Volume: 226 Issue: 4 Pages: 495-502

    • DOI

      10.1007/s00221-013-3461-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuromagnetic activation following active and passive finger movement.2013

    • Author(s)
      Onishi H, et al
    • Journal Title

      Brain and Behavior

      Volume: 3 Issue: 2 Pages: 178-192

    • DOI

      10.1002/brb3.126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation.2013

    • Author(s)
      Kojima S, Onishi H, et al
    • Journal Title

      BMC Neuroscience

      Volume: 14 Issue: 1 Pages: 43-43

    • DOI

      10.1186/1471-2202-14-43

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of the Human Premotor Cortex During Motor Preparation in Visuomotor Tasks2013

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kirimoto H, Tsubaki A, Suzuki M, Tamaki H, Murakami H and Kameyama S
    • Journal Title

      Brain Topography

      Volume: 26 Issue: 4 Pages: 581-590

    • DOI

      10.1007/s10548-013-0299-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visuo-motor related time analysis using electroencephalograms.2013

    • Author(s)
      Yotani K., Tamaki H., Nakamoto H., Yuki A., Kirimoto H., Kitada K., Ogita F., Mori S.
    • Journal Title

      World Journal of Neuroscience

      Volume: 3 Issue: 03 Pages: 142-146

    • DOI

      10.4236/wjns.2013.33018

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement2013

    • Author(s)
      Miyaguchi S, Onishi H, Kojima S, Sugawara K, Tsubaki A, Kirimoto H, Tamaki H, Yamamoto N
    • Journal Title

      Brain research

      Volume: 1529 Pages: 83-91

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the number of pins and inter-pin distance on somatosensory evoked magnetic fields following mechanical tactile stimulation2013

    • Author(s)
      Onishi H, Sugawara K, Yamashiro K, Sato D, Suzuki M, Kirimoto H, Tamaki H, Murakami H, Kameyama S
    • Journal Title

      Brain Research

      Volume: 1535 Pages: 78-88

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 補足運動野に対する経頭蓋直流電流陰極刺激が先行随伴性姿勢調節に及ぼす影響2013

    • Author(s)
      吉田翔太,桐本光,松本卓也,小島翔,鈴木誠,大西秀明,田巻弘之
    • Journal Title

      臨床神経生理学

      Volume: 41 Pages: 202-208

    • NAID

      130004627138

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 桐本光,浅尾章彦,小山龍一郎,田巻弘之,大西秀明2016

    • Author(s)
      桐本光,浅尾章彦,小山龍一郎,田巻弘之,大西秀明
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      福島
    • Year and Date
      2016-10-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Modulation of somatosensory evoked potentials after transcranial static magnetic field stimulation over primary and supplementary motor cortices2015

    • Author(s)
      Kirimoto H, Tamaki H, Onishi H
    • Organizer
      Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modulation of somatosensory evoked potentials after transcranial static magnetic field stimulation over human motor cortex2015

    • Author(s)
      Kirimoto H, Tamaki H, Matsumoto T, Sugawara K, Onishi H
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 一次感覚運動野に対する経頭蓋静磁場刺激が体性感覚誘発電位に及ぼす影響2014

    • Author(s)
      桐本光,田巻弘之,松本卓也,菅原和宏,大西秀明
    • Organizer
      第44回日本臨床神経生理学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 固有受容感覚情報の違いが短潜時求心性抑制に及ぼす影響 ‐筋力制御と肢位制御‐2014

    • Author(s)
      桐本光,田巻弘之,松本卓也,大西秀明
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of transcranial static magnetic field stimulation over the sensorimotor cortex on somatosensory evoked potentials in human2014

    • Author(s)
      Kirimoto H, Tamaki H, Matusmoto T, Sugawara K and Onishi H
    • Organizer
      30th International Congress on Clinical Neurophysiology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] 同側手内筋間および利き手‐非利き手間における皮質中継時間の違い2013

    • Author(s)
      桐本光,田巻弘之,鈴木誠,菅原和広,大山峰生,大西秀明
    • Organizer
      第28回日本生体磁気学会
    • Place of Presentation
      新潟
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential sensori-motor modulations on the load compliance during maintaining constant finger force or position2013

    • Author(s)
      Kirimoto H, Tamaki H, Onishi H, Suzuki M, Matsumoto T, Yotani K
    • Organizer
      18th annual congress of the European College of Sport Science
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2013 Research-status Report
  • [Presentation] 経頭蓋直流電流刺激による高次運動連合野及び一次感覚運動野の可塑的変化2013

    • Author(s)
      桐本光
    • Organizer
      第21回 日本運動生理学会大会
    • Place of Presentation
      埼玉
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] tDCSによる高次運動連合野の可塑的変化2013

    • Author(s)
      桐本光
    • Organizer
      第25回 九州神経生理研究会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] The difference in the cortical relay time between intrinsic muscles and between homonymous muscles of its dominant and non-dominant hands2013

    • Author(s)
      Kirimoto H, Matsumoto T, Tamaki H, Suzuki M, Miyaguchi S, Sugawara K, onishi H
    • Organizer
      5th Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2013 Research-status Report
  • [Presentation] 静的筋収縮時の運動負荷形式によるCutaneo-Muscular Reflexの違い‐筋力制御と肢位制御‐2013

    • Author(s)
      桐本光,田巻弘之,松本卓也,鈴木誠,宮口翔太,菅原和広,大西秀明
    • Organizer
      第68回 日本体力医学会大会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 一次感覚運動野に対する経頭蓋静磁場刺激が体性感覚誘発電位に及ぼす影響2013

    • Author(s)
      桐本光,田巻弘之,松本卓也,大西秀明
    • Organizer
      第7回日本作業療法研究学会学術大会
    • Place of Presentation
      広島
    • Related Report
      2013 Research-status Report
  • [Presentation] 静的筋収縮時の運動負荷形式による短潜時求心性抑制及び促通の違い‐筋力制御と肢位制御‐2013

    • Author(s)
      桐本光,松本卓也,大西秀明,鈴木誠,宮口翔太,菅原和広,田巻弘之
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] Gaiting of cutaneo-muscular reflexes and somatosensory evoked potentials differs with the load compliance during maintaining constant finger force or position2013

    • Author(s)
      Kirimoto H, Matsumoto T, Tamaki H, Suzuki M, Miyaguchi S, Sugawara K, onishi H
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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