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Behavioral training based on the reward and paired associative stimulation: improvement of reciprocal inhibition dysfunction

Research Project

Project/Area Number 25350632
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKitasato University

Principal Investigator

SUZUKI Makoto  北里大学, 医療衛生学部, 教授 (80554302)

Co-Investigator(Kenkyū-buntansha) KIRIMOTO Hikari  新潟医療福祉大学, 医療技術学部, 教授 (40406260)
ONISHI Hideaki  新潟医療福祉大学, 医療技術学部, 教授 (90339953)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords運動学習 / 経頭蓋磁気刺激 / 行動学習
Outline of Final Research Achievements

Reciprocal inhibition of antagonist muscles is crucial for motor learning in humans. Reward probability differentially altered behavioral probability and corticospinal excitability for reciprocal muscles, including the reward-related circuit. In addition, paired associative stimulation (PAS) is used to induce plasticity in the human motor cortex. Although reciprocal inhibition of antagonist muscles plays a fundamental role in human movements, (a) change in cortical circuits for reciprocal muscles by reward probability and (b) change in cortical circuits for reciprocal muscles by PAS are unknown. The results of this study implied that (a) reward probability differentially altered behavioral probability and corticospinal excitability for reciprocal muscles and (b) the cortical excitability for antagonist muscle within M1 decreased by PAS.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (45 results)

All 2015 2014 2013

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Acknowledgement Compliant: 5 results,  Open Access: 3 results) Presentation (27 results) (of which Int'l Joint Research: 2 results) Book (4 results)

  • [Journal Article] Time course of change in movement structure during learning of goal-directed movement2015

    • Author(s)
      Suzuki M, Kirimoto H, Sugawara K, Kasahara Y, Kawaguchi T, Ishizaka I, Yamada S, Matsunaga A, Fukuda M, Onishi H
    • Journal Title

      Journal of Medical and Biological Engineering

      Volume: 35(1) Issue: 1 Pages: 113-124

    • DOI

      10.1007/s40846-015-0012-0

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reliability and validity of the Upper-Body Dressing Scale in patients with vascular dementia with hemiparesis2015

    • Author(s)
      Arisa Endo, Makoto Suzuki, Atsumi Akagi, Naoyuki Chiba, Ikuyo Ishizaka, Atsuhiko Matsunaga, Michinari Fukuda
    • Journal Title

      Occupational Therapy Internaitonal

      Volume: 22 Issue: 1 Pages: 10-18

    • DOI

      10.1002/oti.1378

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Factors decreasing caregiver burden to allow patients with cerebrovascular disease to continue in long-term home care2015

    • Author(s)
      Aki Watanabe, Michinari Fukuda, Makoto Suzuki, Takayuki Kawaguchi, Toshiya Habata, Tsugio Akutsu, Tadashi Kanda
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 24 Issue: 2 Pages: 424-430

    • DOI

      10.1016/j.jstrokecerebrovasdis.2014.09.013

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Relation between Bilateral Knee Muscle Strength and Gait Performance after Stroke: the Predictive Value for Gait Performance2015

    • Author(s)
      Makoto Watanabe, Makoto Suzuki, Yuko Sugimura, Takayuki Kawaguchi, Aki Watanabe, Kazuhiko Shibata, Michinari Fukuda
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 27 Pages: 3227-3232

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Motor cortex-evoked activity in reciprocal muscles is modulated by reward probability2014

    • Author(s)
      Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Mineo Oyama, Sumio Yamada, Jun-ichi Yamamoto, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e90773-e90773

    • DOI

      10.1371/journal.pone.0090773

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Induction of intracortical plasticity for reciprocal muscles by paired associative stimulation2014

    • Author(s)
      Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Makoto Watanabe, Shinobu Shimizu, Ikuyo Ishizaka, Sumio Yamada, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi
    • Journal Title

      Brain and Behavior

      Volume: 4 Issue: 6 Pages: 822-832

    • DOI

      10.1002/brb3.280

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effect of Transcranial Static Magnetic Field Stimulation Over the Sensorimotor Cortex on Somatosensory Evoked Potentials in Humans2014

    • Author(s)
      Kirimoto H, Tamaki H, Matsumoto T, Suzuki M, Sugawara K, Oyama M, Onishi H.
    • Journal Title

      Brain stimulation

      Volume: 7 Issue: 6 Pages: 836-840

    • DOI

      10.1016/j.brs.2014.09.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Sensorimotor Modulation Differs with Load Type during Constant Finger Force or Position2014

    • Author(s)
      Kirimoto H, Tamaki H, Suzuki M, Matsumoto T, Sugawara K, Kojima S, Onishi H
    • Journal Title

      PloS one

      Volume: 9 Issue: 9 Pages: e108058-e108058

    • DOI

      10.1371/journal.pone.0108058

    • NAID

      120006800810

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Risk factors for onset of depression after heart failure hospitalization2014

    • Author(s)
      Yuko Shimizu, Makoto Suzuki, Hisako Okumura, Sumio Yamada
    • Journal Title

      Journal of Cardiology

      Volume: 64 Issue: 1 Pages: 37-42

    • DOI

      10.1016/j.jjcc.2013.11.003

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of the number of pins and inter-pin distance on somatosensory evoked magnetic fields following mechanical tactile stimulation.2013

    • Author(s)
      Onishi H, Sugawara K, , Yamashiro K, Sato D, Suzuki M, Kirimoto H, Tamaki H, Murakami H, Kameyama S.
    • Journal Title

      Brain Research

      Volume: 1535 Pages: 78-88

    • DOI

      10.1016/j.brainres.2013.08.048

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting Recovery of Cognitive Function Soon after Stroke: Differential Modeling of Logarithmic and Linear Regression.2013

    • Author(s)
      Makoto Suzuki, Yuko Sugimura, Sumio Yamada, Yoshitsugu Omori, Masaaki Miyamoto, Jun-ichi Yamamoto.
    • Journal Title

      Plos One

      Volume: 8 Issue: 1 Pages: 53488-53488

    • DOI

      10.1371/journal.pone.0053488

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of the Human Premotor Cortex During Motor Preparation in Visuomotor Tasks2013

    • Author(s)
      Sugawara K, Onishi H, Yamashiro K, Kirimoto H, Tsubaki A, Suzuki M, Tamaki H, Murakami H and Kameyama S
    • Journal Title

      Brain Topography

      Volume: 26 Issue: 4 Pages: 581-590

    • DOI

      10.1007/s10548-013-0299-5

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuromagnetic activation following active and passive finger movement.2013

    • Author(s)
      Onishi H, et al
    • Journal Title

      Brain and Behavior

      Volume: 3 Issue: 2 Pages: 178-192

    • DOI

      10.1002/brb3.126

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of the cortical silent period elicited by single- and paired-pulse transcranial magnetic stimulation.2013

    • Author(s)
      Kojima S, Onishi H, et al
    • Journal Title

      BMC Neuroscience

      Volume: 14 Issue: 1 Pages: 43-43

    • DOI

      10.1186/1471-2202-14-43

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Relation between reward and behavior probabilities during trial-and-error decision-making2015

    • Author(s)
      Makoto Suzuki, Takayuki Kawaguchi, Makoto Watanabe, Shinobu Shimizu, Aki Watanabe, Atsuhiko Matsunaga, Michinari Fukuda
    • Organizer
      Association for Behavior Analysis International’s 8th International Conference
    • Place of Presentation
      Hotel Granvia Kyoto, Kyoto
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motor imagery combined with action observation of chopstics use facilitates motor cortex excitability in dominant hemisphere2015

    • Author(s)
      Shinobu Shimizu, Kazuhiko Shibata, Makoto Suzuki, Makoto Watanabe, Takayuki Kawaguchi, Yoshida S, Michinari Fukuda, Atsuhiko Matsunaga
    • Organizer
      20 th annual congress of the European College of Sport Science
    • Place of Presentation
      Clarion Hotel & Congress Malmo Live, Malmo, Sweden
    • Year and Date
      2015-06-24 – 2015-06-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Modulation of cortical somatosensory processing in human: a static magnetic field stimulation study2015

    • Author(s)
      Hikari Kirimoto, Hideaki Onishi, Makoto Suzuki
    • Organizer
      6 th International Conference on Complex Medical Engineering
    • Place of Presentation
      岡山コンベンションセンター, 岡山県岡山市
    • Year and Date
      2015-06-18 – 2015-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of transcranial direct current stimulation on corticomotor excitability during active and passive finger movement2015

    • Author(s)
      Hideaki Onishi, Miyaguchi Shota, Makoto Suzuki, Hikari Kirimoto
    • Organizer
      6 th International Conference on Complex Medical Engineering
    • Place of Presentation
      岡山コンベンションセンター, 岡山県岡山市
    • Year and Date
      2015-06-18 – 2015-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex activity for reciprocal muscles while trial-and-error behavioral learning2015

    • Author(s)
      Makoto Suzuki, Takayuki Kawaguchi, Makoto Watanabe, Hikari Kirimoto, Hideaki Onishi, Michinari Fukuda
    • Organizer
      6 th International Conference on Complex Medical Engineering
    • Place of Presentation
      岡山コンベンションセンター, 岡山県岡山市
    • Year and Date
      2015-06-18 – 2015-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex activity for reciprocal muscles while trial-and-error behavioral learning2015

    • Author(s)
      Makoto Suzuki, Takayuki Kawaguchi, Makoto Watanabe, Hikari Kirimoto, Hideaki Onishi, Michinari Fukuda
    • Organizer
      6 th International Conference on Complex Medical Engineering
    • Place of Presentation
      Okayama Convention Center, Okayama
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The changes over time in dressing ability after stroke2015

    • Author(s)
      Shotaro Sasaki, Yoshitsugu Omori, Makoto Suzuki
    • Organizer
      41th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      Gonzalez Convention Center, San Antonio, Texas, USA
    • Year and Date
      2015-05-22 – 2015-05-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of an upper extremity behavior measures for patients with post-stroke hemiparesis2015

    • Author(s)
      Koshi Matsuoka, Makoto Suzuki, Aki Watanabe, Koji Misawa, Michinari Fukuda
    • Organizer
      41th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      Gonzalez Convention Center, San Antonio, Texas, USA
    • Year and Date
      2015-05-22 – 2015-05-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex-evoked activity correlates with reinforcement of trial-and-error behavioral learning2015

    • Author(s)
      Makoto Suzuki
    • Organizer
      41th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      Gonzalez Convention Center, San Antonio, Texas, USA
    • Year and Date
      2015-05-22 – 2015-05-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Transcranial direct current stimulation over the prefrontal cortex alters reinforcement of trial-and-error behavioural learning2015

    • Author(s)
      Takayuki Kawaguchi, Makoto Suzuki, Makoto Watanabe, Shinobu Shimizu, Kazuhiko Shibata, Aki Watanabe, Kayoko Takahashi, Michinari Fukuda
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore Expo Convention and Exhibition Centre, Singapore
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex-evoked activity in reciprocal muscles correlates with reinforcement of trial-and-error behavioral learning2015

    • Author(s)
      Makoto Suzuki, Takayuki Kawaguchi, Makoto Watanabe, Shinobu Shimizu, Hikari Kirimoto, Hideaki Onishi, Atsuhiko Matsunaga, Michinari Fukuda
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore Expo Convention and Exhibition Centre, Singapore
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex-evoked activity in reciprocal muscles is modulated by reward probability2014

    • Author(s)
      Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Makoto Watanabe, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi
    • Organizer
      9th Form of Neuroscience on Federation of European Neuroscience Societies
    • Place of Presentation
      Milano C ongressi, Milan, Italy
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Induction of intracortical plasticity for reciprocal muscles by paired associative stimulation2014

    • Author(s)
      Makoto Watanabe, Makoto Suzuki, Kazuhiro Sugawara, Takayuki Kawaguchi, Kayoko Takahashi, Shinobu Shimizu, Atsuhiko Matsunaga, Michinari Fukuda, Hideaki Onishi
    • Organizer
      9th Form of Neuroscience on Federation of European Neuroscience Societies
    • Place of Presentation
      Milano C ongressi, Milan, Italy
    • Year and Date
      2014-07-05 – 2014-07-09
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of behavioral approach for lower-body dressing in cognitive dysfunction: single subject design2014

    • Author(s)
      Fumiko Morishita, Go Kinoshita, Makoto Suzuki
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor representational maps of primary motor cortex for reciprocal muscles2014

    • Author(s)
      Takumi Oyama, Makoto Suzuki, Hikari Kirimoto, Mineo Oyama, Hideaki Onishi
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Motor cortex activity for reciprocal muscles while behavior learning2014

    • Author(s)
      Makoto Suzuki, Hikari Kirimoto, Kazuhiro Sugawara, Mineo Oyama, Hideaki Onishi
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Reliability and validity of measurements of upper-body dressing for dementia2014

    • Author(s)
      Arisa Endo, Makoto Suzuki, Atumi Akagi, Naoyuki Chiba
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Relative impact of dementia on behavioral independence and disturbances2014

    • Author(s)
      Naoyuki Chiba, Makoto Suzuki, Teruaki Endo, Arisa Endo, Yusuke Nitanda, Nao Tanabe
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] The relation between toiletting behavior and impairments after stroke2014

    • Author(s)
      Eri Nakamura, Makoto Suzuki, Mayumi Hatakeyama, Seiichiro Sugimura, Shotaro Sasaki, Yuta Furuta, Yuka Koremura, Masuo Sasa
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] The effects of meaningful finger tapping movement on excitability of the contralateral spinal anterior horn cell2014

    • Author(s)
      Takuya Matsumoto, Hikari Kirimoto, Shota Yoshida, Makoto Suzuki, Mineo Oyama
    • Organizer
      16 th International Congress of the World Federation of Occupational Therapists
    • Place of Presentation
      パシフィコ横浜, 神奈川県横浜市
    • Year and Date
      2014-06-18 – 2014-06-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Predicting recovery of cognitive, physical and behavioral functions2014

    • Author(s)
      Makoto Suzuki
    • Organizer
      40th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      MacCormick Place, Chicago, USA
    • Year and Date
      2014-05-23 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Time course of change in movement structure during learning of goal-directed behavior2014

    • Author(s)
      Takayuki Kawaguchi, Makoto Suzuki, Makoto Watanabe, Kayoko Takahashi, Aki Watanabe, Akie Kawamura, Michinari Fukuda
    • Organizer
      40th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      MacCormick Place, Chicago, USA
    • Year and Date
      2014-05-23 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The relation between bilateral knee muscle strength and gait behavior after stroke2014

    • Author(s)
      Makoto Watanabe, Makoto Suzuki, Takayuki Kawaguchi, Kayoko Takahashi, Aki Watanabe, Akie Kawamura, Michinari Fukuda
    • Organizer
      40th Annual Convention on Association for Bahavior Analysis International
    • Place of Presentation
      MacCormick Place, Chicago, USA
    • Year and Date
      2014-05-23 – 2014-05-27
    • Related Report
      2014 Research-status Report
  • [Presentation] The difference in the cortical relay time between intrinsic muscles and between homonymous muscles of its dominant and non-dominant hands2013

    • Author(s)
      Hikari Kirimoto, Takuya Matsumoto, Hiroyuki Tamaki, Makoto Suzuki, Shota Miyaguchi, Kazuhiro Sugawara, Hideaki Onishi
    • Organizer
      5 th Asian and Oceanian Congress of Clinical Neurophysiology
    • Place of Presentation
      Bali Nusa Dua Convention Center (Indonesia)
    • Related Report
      2013 Research-status Report
  • [Presentation] Gaiting of cutaneo-muscular reflexes and somatosensory evoked potentials differs with the load compliance during maintaining constant finger force or position2013

    • Author(s)
      Hikari Kirimoto, Takuya Matsumoto, Hiroyuki Tamaki, Makoto Suzuki, Syota Miyaguchi, Kazuhiro Sugawara, Hideaki Onishi
    • Organizer
      Neuroscience 2013
    • Place of Presentation
      San Diego Convention Center (USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] The effect of anodal transcrinial direct current stimulation to the sensorimotor cortex on somatosensory evoked magnetic fields2013

    • Author(s)
      Kazuhiro Sugawara, Hideaki Onishi, Koya Yamashiro, Sho Kojima, Shota Miyaguchi, Atsuhiro Tsubaki, Makoto Suzuki, Hikari Kirimoto, Hiroyuki Tamaki, Hiroatsu Murakami, Shigeki Kameyama
    • Organizer
      World Congress of Neurology
    • Place of Presentation
      Messe Wien Exhibition & Congress Center (Austria)
    • Related Report
      2013 Research-status Report
  • [Presentation] Differential sensori-motor modulations on the load compliance during maintaining constant finger force or position2013

    • Author(s)
      Hikari Kirimoto, Hiroyuki Tamaki, Hideaki Onishi, Makoto Suzuki, Takuya Matsumoto, Yotani, Kengo
    • Organizer
      18 th European College of Sport Science
    • Place of Presentation
      Institut Nacional d'Educacio Fisica de Catalunya (Spain)
    • Related Report
      2013 Research-status Report
  • [Book] PT・OTのための高次脳機能障害ABC2015

    • Author(s)
      鈴木誠. 網本和(編)
    • Total Pages
      11
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Book] ケースで学ぶ行動分析学による問題解決2015

    • Author(s)
      鈴木誠. 日本行動分析学会(編), 山本淳一, 武藤崇, 鎌倉やよい(責任編集)
    • Total Pages
      8
    • Publisher
      金剛出版
    • Related Report
      2015 Annual Research Report
  • [Book] 標準作業療法学 専門分野 日常生活活動・社会生活行為学2014

    • Author(s)
      鈴木誠
    • Total Pages
      373
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Book] 理学療法チェックリスト2014

    • Author(s)
      鈴木誠
    • Total Pages
      380
    • Publisher
      三輪書店
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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