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The influence of Metabolic function and therapeutic evaluation for spastic hypertonia after central nerveous system injury

Research Project

Project/Area Number 25350647
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKinki University

Principal Investigator

UCHIYAMA Takuya  近畿大学, 医学部附属病院, 講師 (50278686)

Co-Investigator(Kenkyū-buntansha) KATO Amami  近畿大学, 医学部, 教授 (00233776)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords痙縮 / 代謝 / 治療 / 安静時代謝 / ITB療法
Outline of Final Research Achievements

We realized that patients with spasticity or dystonia exhibit hypermetabolism due to spastic hypertonia, and investigated to what extent improvement of spastic hypertonia as a result of treatment affects metabolic function by measuring resting metabolism using a respiratory gas analyzer. All 20 patients for whom resting metabolism was measured exhibited resting hypermetabolism before the procedure, which declined in all patients after the procedure. This reduction was particularly marked in the 4 patients with dystonia and the 2 patients with spastic cerebral palsy, for whom resting metabolic rate measured before surgery was over 1.7 times the standardized value.Metabolic function also tended to correlate with improvements in Ashworth score, and we considered that metabolic function should be utilized in adjusting ITB treatment after the procedure

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2016 2015 2014 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] ITBによる痙縮治療の適応と効果2016

    • Author(s)
      内山卓也、加藤天美
    • Journal Title

      脳神経外科ジャーナル

      Volume: 25 Pages: 149-156

    • NAID

      130005127607

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] 痙縮に対する機能的脳神経外科治療の役割2016

    • Author(s)
      内山卓也、加藤天美
    • Organizer
      第55回日本定位機能神経外科学会
    • Place of Presentation
      仙台(江陽グランドホテル)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ITB療法の治療効果ー疾患および罹患肢別による検討ー2015

    • Author(s)
      内山卓也
    • Organizer
      第74回日本脳神経外科学会学術総会
    • Place of Presentation
      札幌(ロイトン札幌)
    • Year and Date
      2015-10-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Long term follow up of intrathecal baclofen therapy for spastic hypertonia2015

    • Author(s)
      Takuya Uchiyama
    • Organizer
      INS 12th world congress
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2015-06-08 – 2015-06-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Long term follow up of intrathecal baclofen therapy for spastic hypertonia2015

    • Author(s)
      Takuya Uchiyama
    • Organizer
      International Neuromodulation Society 12th World Congress
    • Place of Presentation
      Montreal (Fairmont Queen Elizabeth Hotel)
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ITBによる痙縮治療の適応と効果2015

    • Author(s)
      内山卓也
    • Organizer
      第35回日本脳神経外科コングレス
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2015-05-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] ITBによる痙縮治療の適応と効果2015

    • Author(s)
      内山卓也
    • Organizer
      第35回日本脳神経外科コングレス総会
    • Place of Presentation
      横浜:パシフィコ横浜
    • Year and Date
      2015-05-07 – 2015-05-10
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 筋緊張異常症に対するバクロフェン髄注療法の効果と長期成績2015

    • Author(s)
      内山卓也
    • Organizer
      第54回 日本定位機能神経外科学会
    • Place of Presentation
      東京:都市センターホテル
    • Year and Date
      2015-01-17 – 2015-01-18
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 筋緊張異常症に対するバクロフェン髄注療法2014

    • Author(s)
      内山卓也
    • Organizer
      第73回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜: パシフィコ横浜
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 筋緊張異常症に対するITB療法の長期成績

    • Author(s)
      内山卓也
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 成人痙縮に対する機能的脳神経外科治療

    • Author(s)
      内山卓也
    • Organizer
      第53回日本定位機能外科学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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