| Project/Area Number |
25350648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kansai University of Welfare Sciences |
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Principal Investigator |
Hiroshima Reiko 関西福祉科学大学, 保健医療学部, 准教授 (40404777)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masahito 関西福祉科学大学, 保健医療学部, 教授 (70084902)
MORI Yoshiaki 関西福祉科学大学, 保健医療学部, 教授 (70268192)
山本 真紀 関西福祉科学大学, 保健医療学部, 教授 (60240123)
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| Research Collaborator |
YAMAJI Jumko 関西福祉科学大学, 健康福祉学部, 准教授 (40340559)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 廃用性筋萎縮 / 回復過程 / インターロイキン6 (IL-6) / ミオシン重鎖 (MHC) / 抗炎症剤 / ミオシン重鎖（MHC) / リハビリテーション / 熱ショックタンパク質70(HSP70) / ミオシン重鎖(MHC)アイソフォーム / 熱ショックタンパク質70（HSP70) / ミオシン重鎖（MHC)アイソフォーム |
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| Outline of Final Research Achievements |
The study prepared the disuse atrophy in the experimental animals and examined the effect of inflammation on the process of recovery from atrophy as compared the group which received the injection of anti-inflammatory drug just before reloading on the atrophied muscle with the non-injection group. The real-time PCR analyzed the mRNA expression of interleukin 6 (IL-6) and myosin heavy chain (MHC) isoforms. The injection group showed decreased IL-6 mRNA expression, which the migration of immune cells might be inhibited by anti-inflammatory drug. MHC-slow type decreased less in the injection group, but MHC-fast type showed no effect. It could be caused by activation of the cytokines other than IL-6. The study suggested that inhibition of inflammation in the early stage might facilitate the process of recovery.
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