The promotional effect of electrotherapy by optimum microcurrent on pressure ulcer healing
| Project/Area Number |
25350649
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kobe Gakuin University |
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Principal Investigator |
Sugimoto Masaharu 神戸学院大学, 総合リハビリテーション学部, 教授 (20379457)
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| Co-Investigator(Kenkyū-buntansha) |
TERASHI Hiroto (MAESHIGE Noriaki) 神戸大学医学部附属病院, 形成外科, 教授 (80217421)
前重 伯壮 神戸大学, 保健学研究科, 助教 (90617838)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 直流微弱電気刺激 / パルス電流 / 周波数 / 褥瘡 / 線維芽細胞 / 筋線維芽細胞 / 直流微弱電流刺激 / α‐SMA / TGF－β１ / α-SMA / TGF-β1 / ヒト皮膚由来線維芽細胞 / 細胞の増殖 |
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| Outline of Final Research Achievements |
(1)Discharging of reverse current is necessary for electrical stimulation to promote galvanotaxis of fibroblasts.(2)We observed that low-frequency (1, 2, or 4 Hz) electrical stimulation (intensity; 200 μA) promoted proliferation of fibroblasts.(3)We are currently investigating the frequency to induce fibroblasts differentiation into myofibroblasts.(4)There were several clinical studies that investigated the effects of electrotherapy for pressure ulcers healing, and the wound contraction was observed without side effects in all of the cases. We made the instruction manual of electrical stimulation device for future clinical trials.
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Report
(4 results)
Research Products
(19 results)
