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The promotional effect of electrotherapy by optimum microcurrent on pressure ulcer healing

Research Project

Project/Area Number 25350649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKobe Gakuin University

Principal Investigator

Sugimoto Masaharu  神戸学院大学, 総合リハビリテーション学部, 教授 (20379457)

Co-Investigator(Kenkyū-buntansha) TERASHI Hiroto (MAESHIGE Noriaki)  神戸大学医学部附属病院, 形成外科, 教授 (80217421)
前重 伯壮  神戸大学, 保健学研究科, 助教 (90617838)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords直流微弱電気刺激 / パルス電流 / 周波数 / 褥瘡 / 線維芽細胞 / 筋線維芽細胞 / 直流微弱電流刺激 / α‐SMA / TGF-β1 / α-SMA / TGF-β1 / ヒト皮膚由来線維芽細胞 / 細胞の増殖
Outline of Final Research Achievements

(1)Discharging of reverse current is necessary for electrical stimulation to promote galvanotaxis of fibroblasts.(2)We observed that low-frequency (1, 2, or 4 Hz) electrical stimulation (intensity; 200 μA) promoted proliferation of fibroblasts.(3)We are currently investigating the frequency to induce fibroblasts differentiation into myofibroblasts.(4)There were several clinical studies that investigated the effects of electrotherapy for pressure ulcers healing, and the wound contraction was observed without side effects in all of the cases. We made the instruction manual of electrical stimulation device for future clinical trials.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 1 results) Book (4 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Monophasic Pulsed 200-μA Current Promotes Galvanotaxis With Polarization of Actin Filament and Integrin α2β1 in Human Dermal Fibroblasts.2016

    • Author(s)
      Mikiko Uemura, Noriaki Maeshige, Yuka Koga,Michiko Ishikawa-Aoyama, Makoto Miyoshi, Masaharu Sugimoto, Hiroto Terashi, and Makoto Usami
    • Journal Title

      Eplasty

      Volume: 16

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 褥瘡に対する電気刺激療法の治癒促進効果に関する検証2015

    • Author(s)
      出口太紀,岩川展春,杉元雅晴,原田 孝
    • Journal Title

      物理療法科学

      Volume: 22 Pages: 44-47

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 裾瘡に対する電気刺激療法の治癒促進効果に関する検証2015

    • Author(s)
      出口太紀,岩川展春,杉元雅晴,原田 孝
    • Journal Title

      物理療法科学

      Volume: 22

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 褥瘡対策チームで発揮できる理学療法技術2014

    • Author(s)
      前重伯壮,杉元雅晴,吉川義之,他4名
    • Journal Title

      理学療法学

      Volume: 41(8) Pages: 690-698

    • NAID

      110009884633

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 麻痺,拘縮のある患者の褥瘡ケア2014

    • Author(s)
      杉元雅晴,前重伯壮
    • Journal Title

      WOC Nursing

      Volume: 2(4) Pages: 24-31

    • Related Report
      2014 Research-status Report
  • [Journal Article] 褥瘡治癒を促進する専用電気刺激治療器の開発―臨床治験による安全性と効果の確認―2013

    • Author(s)
      杉元雅晴
    • Journal Title

      理学療法学

      Volume: 40(8) Pages: 732-738

    • NAID

      110009829387

    • Related Report
      2013 Research-status Report
  • [Journal Article] 慢性創傷に対する理学療法.2013

    • Author(s)
      杉元雅晴,前重伯壮,吉川義之
    • Journal Title

      理学療法

      Volume: 30(4) Pages: 402-410

    • Related Report
      2013 Research-status Report
  • [Journal Article] 臨床に生かす,新しい物理療法 創傷・骨折治癒2013

    • Author(s)
      吉野 修,杉元雅晴
    • Journal Title

      J. Clinical Rehabilitation

      Volume: 22(8) Pages: 101-107

    • Related Report
      2013 Research-status Report
  • [Presentation] 褥瘡に対して直流微弱電流刺激で得られた結果の検証2015

    • Author(s)
      工藤和善,水木猛夫,南本俊之,杉元雅晴
    • Organizer
      第23回日本物理療法学会学術大会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-10-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 物理療法の進歩―トランスレーショナル リサーチ―2015

    • Author(s)
      杉元雅晴
    • Organizer
      第23回日本物理療法学会 学会長講演
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 線維芽細胞の電気走性における直流微弱電流刺激強度とintegrinα2β1の発現の関連性2015

    • Author(s)
      植村弥希子,前重伯壮,古賀由華,吉川義之,藤島里英子,杉元雅晴
    • Organizer
      第17回日本褥瘡学会学術集会
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 褥瘡に対する電気刺激療法の治癒効果に関する検証2014

    • Author(s)
      出口太紀,岩川展春,杉元雅晴,原田 孝
    • Organizer
      第22回日本物理療法学会学術集会
    • Place of Presentation
      松本市;信州大学病院
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒト皮膚線維芽細胞増殖における電気刺激周波数の関連性2014

    • Author(s)
      吉川義之,杉元雅晴,前重伯壮,他4名
    • Organizer
      第16回日本褥瘡学会学術集会
    • Place of Presentation
      名古屋市;名古屋国際会議場
    • Year and Date
      2014-08-29 – 2014-08-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 褥瘡対策チームで発揮できる理学療法技術2014

    • Author(s)
      杉元雅晴
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      横浜;パシフィコ横浜
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 理学療法を活かす褥瘡ケア 評価・治療・予防2016

    • Author(s)
      杉元雅晴(編集)
    • Total Pages
      200
    • Publisher
      文光堂
    • Related Report
      2015 Annual Research Report
  • [Book] 今日の理学療法指針;褥瘡.慢性創傷.2015

    • Author(s)
      杉元雅晴,内山 靖(総編集)
    • Total Pages
      525
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 褥瘡.理学療法から診る廃用症候群―基礎・予防・介入―2014

    • Author(s)
      杉元雅晴,吉川義之,前重 伯壮
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 標準理学療法学 物理療法学 第4版(褥瘡)2013

    • Author(s)
      杉元雅晴 (編集)網本和,菅原憲一
    • Publisher
      医学書院
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 電気刺激治療器2014

    • Inventor(s)
      杉元 雅晴
    • Industrial Property Rights Holder
      学校法人神戸学院
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-185752
    • Filing Date
      2014-09-11
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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