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Noninvasive Evaluation of Left Ventricular Force-Frequency Relationships by Measuring Carotid Arterial Wave Intensity

Research Project

Project/Area Number 25350651
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionHimeji Dokkyo University

Principal Investigator

Tanaka Midori  姫路獨協大学, 医療保健学部, 准教授 (50441332)

Co-Investigator(Kenkyū-buntansha) SUGAWARA Motoaki  姫路獨協大学, 医療保健学部, 名誉教授 (60010914)
OGASAWARA Yasuo  川崎医科大学, 医学部, 准教授 (10152365)
IZUMI Tadafumi  北海道医療大学, リハビリテーション科学部, 教授 (40278990)
KAJIYA Fumihiko  川崎医療福祉大学, 医療技術学部, 特任教授 (70029114)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords運動時の心収縮性 / 心血管機能 / Wave Intensity / FFR / 心収縮性指標 / 運動中 / 心臓リハビリテーション / 運動 / 心機能
Outline of Final Research Achievements

We developed a method of noninvasively measuring the force-frequency relation (FFR) during exercise.We enrolled 102 healthy subjects. Using ultrasonic diagnostic equipment, we measured wave intensity (WD1) in the carotid artery and heart rate (HR) before and during bicycle ergometer exercise. FFR’s were constructed by plotting the maximum value of WD1 against heart rate (HR). The coefficient of variation for the measurement of FFR was 0.20, which was within clinically practical range.WD1 increased linearly with an increase in HR during exercise. The slope of the WD1-HR relation was 1.0 ± 0.6 m/s3 bpm, which were lower in women than in men. The independent variable to predict the slope of FFR was BMI. The slope of FFR was smaller for greater BMI.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (17 results)

  • [Journal Article] Does a Two-week High-intensity Treadmill Exercise Improve Arterial Stiffness?2015

    • Author(s)
      田中みどり,菅原基晃,小笠原康夫,仁木清美,梶谷文彦
    • Journal Title

      The Journal of Japanese College of Angiology

      Volume: 55 Issue: 11 Pages: 185-190

    • DOI

      10.7133/jca.15-00005

    • NAID

      130005130117

    • ISSN
      0387-1126, 1880-8840
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of intermittent, moderate-intensity, and short-term aerobic exercise training on arterial stiffness2015

    • Author(s)
      田中みどり,菅原基晃,小笠原康夫,泉唯史,仁木清美,梶谷文彦
    • Journal Title

      Shinzo

      Volume: 47 Issue: 2 Pages: 157-164

    • DOI

      10.11281/shinzo.47.157

    • NAID

      130005125391

    • ISSN
      0586-4488, 2186-3016
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Noninvasive evaluation of left ventricular force-frequency relationships by measuring carotid arterial wave intensity during exercise stress2015

    • Author(s)
      Midori Tanaka, Motoaki Sugawara, Yasuo Ogasawara, Isao Suminoe, Tadafumi Izumi, Kiyomi Niki, Fumihiko Kajiya
    • Journal Title

      J Med Ultrasonics

      Volume: 45 Issue: 1 Pages: 65-70

    • DOI

      10.1007/s10396-014-0554-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中等度強度の定期的有酸素運動が動脈の硬さに与える効果―圧力―ひずみ弾性率(Ep)とスティッフネス・パラメータ(β)の超音波測定による評価 - Effects of Intermittent, Moderate-intensity, and Short-term Aerobic Exercise Training on Arterial Stiffness―Evaluation by Ultrasonic Measurements of Stiffness Parameter and Pressure-strain Elastic Modulus ―2015

    • Author(s)
      田中みどり,菅原基晃,小笠原康夫,泉 唯史,仁木清美,梶谷文彦
    • Journal Title

      心臓

      Volume: 47 Pages: 157-164

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Noninvasive Method of Measuring Force-Frequency Relations to Evaluate Cardiac State of Patients during Exercise for Cardiac Rehabilitation.2014

    • Author(s)
      Tanaka M, Sugawara M, Ogasawara Y, Suminoe I, Izumi T, Niki K, Kajiya F.
    • Journal Title

      Mediterranean Conference on Medical and Biological Engineering and Computing 2013 IFMBE Proceeding 41

      Volume: Proceedings Pages: 1523-1526

    • DOI

      10.1007/978-3-319-00846-2_376

    • ISBN
      9783319008455, 9783319008462
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive Assessment of Left Ventricular Force-FrequencyRelationships by Measuring Carotid Arterial Wave Intensity duringExercise Stress2013

    • Author(s)
      Tanaka M, Sugawara M, Ogasawara Y, Suminoe I, Izumi T, Hiramatsu O, and Kajiya F
    • Journal Title

      ©2013 IEEE, ISSN1557-170X

      Volume: 13799828 Pages: 687-690

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intermittent, moderate-intensity aerobic exercise for only eight weeks reduces arterial stiffness: evaluation by mearurement of stiffness parameter and pressure-strain elastic modulus by use of ultrasonic echo tracking2012

    • Author(s)
      田中みどり
    • Journal Title

      J Med Ultrasonics

      Volume: 40 Issue: 2 Pages: 119-124

    • DOI

      10.1007/s10396-012-0408-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動負荷中の心収縮性の評価:Force-Frequency Relationの非侵襲的測定2016

    • Author(s)
      田中みどり 菅原基晃 小笠原康夫 仁木清美 泉唯史
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハンドグリップ負荷中の心収縮性の変化2016

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美, 泉唯史
    • Organizer
      日本心臓リハビリテーション学会 第1回関西地方会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頸動脈エコーと運動負荷試験を用いた力―収縮頻度関係(FFR)の非観血的計測法2015

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美, 泉唯史
    • Organizer
      第238回日本循環器学会関東甲信越地方会
    • Place of Presentation
      ステーションコンファレンス東京 (東京)
    • Year and Date
      2015-12-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Acute changes in carotid arterial blood velocity immediately after the cessation of exercise.2015

    • Author(s)
      Midori Tanaka, Motoaki Sugawara, Yasuo Ogasawara, Kiyomi Niki and Tadafumi Izumi
    • Organizer
      International Congress on Sports Science Research and Technology Support (icSPORTs)
    • Place of Presentation
      Lisbon (Portugal)
    • Year and Date
      2015-11-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 頸動脈エコーと運動負荷を利用した力―収縮頻度関係の非侵襲的計測法の開発2015

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美, 泉唯史
    • Organizer
      日本超音波医学会 第45回北海道地方会学術集会
    • Place of Presentation
      北海道大学 (北海道)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動負荷中の心機能の非観血的評価法の開発:Force-Frequency Relationの応用2015

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美, 梶谷文彦
    • Organizer
      第21回日本心臓リハビリテーション学会
    • Place of Presentation
      福岡国際会議場 (福岡県)
    • Year and Date
      2015-07-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 2週間の高強度のトレッドミル運動は動脈の弾性率を低下させる2015

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美, 梶谷文彦
    • Organizer
      第88回日本超音波医学会学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪 国際館パミール (東京都)
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動終了直後からの頸動脈血流速度の変化2015

    • Author(s)
      田中みどり,菅原基晃, 小笠原康夫, 仁木清美, 梶谷文彦
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場 (大阪府)
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 運動中の力―収縮頻度関係 (FFR) の非侵襲的測定法の開発: FFRと体格指数 (BMI) の関係2014

    • Author(s)
      田中 みどり,菅原基晃,小笠原康夫,仁木清美,梶谷文彦
    • Organizer
      第226回日本循環器学会関東甲信越地方会
    • Place of Presentation
      東京ステーションコンファレンス
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 2週間の定期的高強度有酸素運動は動脈の硬さ指標を低下させる2014

    • Author(s)
      田中 みどり,菅原基晃,小笠原康夫,仁木清美,梶谷文彦
    • Organizer
      第41回関西地方会学術集会
    • Place of Presentation
      京都府京都市
    • Year and Date
      2014-11-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 2週間の高強度有酸素運動で動脈の硬さは変化するか?2014

    • Author(s)
      田中 みどり,菅原基晃,小笠原康夫,仁木清美,梶谷文彦
    • Organizer
      第55回日本脈管学会
    • Place of Presentation
      岡山県倉敷市 倉敷文芸会館
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動によって得た力‐収縮頻度関係の傾きとBody Mass Index - Wave Intensity (WD1) の応用2014

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 仁木清美,  泉唯史
    • Organizer
      第87回日本超音波医学会学術集会
    • Place of Presentation
      横浜市 パシフィコ横浜
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動中における心収縮性の測定法 - Wave intensityの応用 -2014

    • Author(s)
      田中みどり, 菅原基晃, 小笠原康夫, 梶谷文彦, 仁木清美, 泉唯史
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Research-status Report
  • [Presentation] 運動負荷における頸動脈エコーによる左室拡張能応答指標の 可能性に関する研究2014

    • Author(s)
      泉唯史,田中みどり,菅原基晃,住之江功夫
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Research-status Report
  • [Presentation] 週2~3回の中等度運動を8週間継続すると動脈の硬さは低下する2013

    • Author(s)
      田中みどり,菅原基晃,小笠原康夫,仁木清美,泉唯史,梶谷文彦.
    • Organizer
      第86回日本超音波医学会学術集会
    • Place of Presentation
      大阪 (大阪国際会議場)
    • Related Report
      2013 Research-status Report
  • [Presentation] Noninvasive Assessment of Left Ventricular Force-FrequencyRelationships by Measuring Carotid Arterial Wave Intensity duringExercise Stress2013

    • Author(s)
      Tanaka M, Sugawara M, Ogasawara Y, Suminoe I, Izumi T, Hiramatsu O, and Kajiya F.
    • Organizer
      Institute of Electrical and Electronic Engineers
    • Place of Presentation
      Osaka (大阪国際会議場)
    • Related Report
      2013 Research-status Report
  • [Presentation] A Noninvasive Method of Measuring Force-Frequency Relations to Evaluate Cardiac Contractile State of Patients during Exercise for Cardiac Rehabilitation2013

    • Author(s)
      Midori Tanaka, Motoaki Sugawara,Yasuo Ogasawara, Isao Suminoe, Tadafumi Izumi, Kiyomi Niki,Fumihiko Kajiya.
    • Organizer
      Mediterranean Conference on Medical and Biological Engineering and Computing
    • Place of Presentation
      Seville, Spain (メリアセビィリア))
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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