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Study of optimal stimulation and mechanism of spinal cord stimulation for Parkinson disease with severe frozen gait.

Research Project

Project/Area Number 25350691
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKinki University

Principal Investigator

NAKANO Naoki  近畿大学, 医学部, 講師 (60258027)

Co-Investigator(Kenkyū-buntansha) KATO Amami  近畿大学, 医学部, 教授 (00233776)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsパーキンソン病 / 脊椎硬膜外刺激 / すくみ足 / 歩行障害 / キュー / 脊髄刺激 / 脳内活動 / 前頭葉機能
Outline of Final Research Achievements

A daily living of Parkinson’s disease was aggravated by a gait disturbance such as frozen gait. The The frozen gait could not be well improved by Levodopa and deep brain stimulation directly. A frozen gait was considered one of symptom of start hesitation. Some author reported that start hesitation was improved by visual cue, auditory cue and electrical stimulation. In recently, spinal cord stimulation(SCS) may alleviate motor dysfunction in Parkinson’s disease. The goal of this study is an investigation of mechanism of SCS in patients with Parkinson’s disease. We analyze a cerebral blood oxygenation in Parkinson’s disease with a spinal cord stimulation using near-infrared spectroscopy(NIRS) and/or scalp electroencephalogram. An improvement of gait disturbance result an increase of frontal brain area is measured during a stepping in NIRS. Based on their NIRS, we investigate that optimal parameter of SCS is decided such as low Hertz (<5Hz).

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (17 results)

  • [Journal Article] Successful Combination of Pallidal and Thalamic Stimulation for Intractable Involuntary Movements in Patients with Neuroacanthocytosis2015

    • Author(s)
      Nakano N, kato A(4名省略)
    • Journal Title

      World Neurosurg

      Volume: 84 Issue: 4 Pages: 1177-1184

    • DOI

      10.1016/j.wneu.2015.06.052

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia.2014

    • Author(s)
      Nakano N, Fukawa N, Nakagawa N, Nakanishi K, Tsuji K, Yabuuchi T, Iwakura N, Kato A.
    • Journal Title

      J Neurol Surg A

      Volume: 75 Pages: 350-353

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural Decoding of Single Vowels during Covert Articulation using Electrocorticography2014

    • Author(s)
      Ikeda S, Shibata T, Nakano, Okada R, Tsuyuguchi N, Ikeda K, Kato A
    • Journal Title

      Front Hum Neurosci

      Volume: epub ahead Pages: 1-8

    • DOI

      10.3389/fnhum.2014.00125

    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 脳神経疾患&治療まるわかり帳 てんかん2014

    • Author(s)
      中野直樹
    • Journal Title

      ブレインナーシング

      Volume: 30 Pages: 22-23

    • Related Report
      2014 Research-status Report
  • [Journal Article] Endovascular Microcatheter Provocation Test for the Diagnosis of Glossopharyngeal Neuralgia.2014

    • Author(s)
      Nakano N, Fukawa N, Nakagawa N, Nakanishi K, Tsuji K, Yabuuchi T, Iwakura N, Kato A.
    • Journal Title

      J Neurol Surg A Cent Eur Neurosurg.

      Volume: Jan Pages: 16-16

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 疼痛とDBS2013

    • Author(s)
      中野直樹
    • Journal Title

      精神科

      Volume: 23 Pages: 466-470

    • Related Report
      2013 Research-status Report
  • [Presentation] パーキンソン病に対する脳深部刺激術術後の問題2016

    • Author(s)
      中野直樹、宮内正晴、内山卓也、加藤天美
    • Organizer
      第55回日本定位機能外科学会
    • Place of Presentation
      東京(都市センターホテル)
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳深部刺激術の立ち位置ー 自験例から検討―2015

    • Author(s)
      中野直樹
    • Organizer
      第51回南大阪神経カンファレンス
    • Place of Presentation
      大阪(アゴーラリージェンシー大阪)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視床下核刺激術後の認知機能の低下例2015

    • Author(s)
      中野直樹、宮内正晴、加藤天美
    • Organizer
      第29回日本ニューロモデュレーション学会
    • Place of Presentation
      東京(都市センターホテル)
    • Year and Date
      2015-04-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院におけるてんかん診療院内連携の現状2015

    • Author(s)
      中野直樹、宮内正晴、他
    • Organizer
      全国てんかんセンター協議会総会2015
    • Place of Presentation
      東京(東京医科歯科大学湯島講堂)
    • Year and Date
      2015-02-14 – 2015-02-15
    • Related Report
      2014 Research-status Report
  • [Presentation] よりよいパーキンソン病の脳深部刺激治療をおこなうための医療連携の重要性について2015

    • Author(s)
      中野直樹、宮内正晴、吉岡宏真、他
    • Organizer
      第54回日本定位機能外科学会
    • Place of Presentation
      東京(東京都市センターホテル)
    • Year and Date
      2015-01-16 – 2015-01-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 難治てんかんに対する迷走神経刺激術と脳料離断術とのcombination therapyにいたった例の検討2015

    • Author(s)
      中野直樹、宮内正晴、吉岡宏真、他
    • Organizer
      第38回日本てんかん外科学会
    • Place of Presentation
      東京(東京都市センターホテル)
    • Year and Date
      2015-01-05 – 2015-01-06
    • Related Report
      2014 Research-status Report
  • [Presentation] てんかん症状と現在の治療2014

    • Author(s)
      中野直樹
    • Organizer
      第5回美ら島セミナー
    • Place of Presentation
      沖縄(沖縄協同病院)
    • Year and Date
      2014-11-22 – 2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 温故知新ーてんかん治療2014

    • Author(s)
      中野直樹
    • Organizer
      第73回日本脳神経外科学術総会
    • Place of Presentation
      東京(グランドプリンス ホテル新高輪)
    • Year and Date
      2014-10-10
    • Related Report
      2014 Research-status Report
  • [Presentation] 難治てんかんに対する迷走神経刺激術と脳料離断術とのcombined therapy2014

    • Author(s)
      中野直樹、宮内正晴、吉岡宏真、他
    • Organizer
      第73回日本脳神経外科学術総会
    • Place of Presentation
      東京(グランドプリンス ホテル新高輪)
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Indication of vagus nerve stimulation and callosotomy.2014

    • Author(s)
      Indication of vagus nerve stimulation and callosotomy. Masaharu MIyauchi, Naoki Nakano, Hiromasa Yoshioka, Saori Murakami, Takayuki Tasaki, Jun Shiroma, Amami Kato
    • Organizer
      AESC2014
    • Place of Presentation
      Tokyo(Tokyo Toshi Center Hotel)
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 迷走神経刺激術の手術手技2014

    • Author(s)
      中野直樹、宮内正晴、吉岡宏真、他
    • Organizer
      第48回日本てんかん学会
    • Place of Presentation
      東京(京王プラザホテル)
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 睡眠期てんかん放電重積状態例に対する外科治療例2014

    • Author(s)
      吉岡宏真、田崎貴之、中野直樹、加藤天美
    • Organizer
      第10回日本てんかん学会近畿地方会
    • Place of Presentation
      大阪(大阪大学中之島センター)
    • Year and Date
      2014-08-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 機能外科疾患に対するCombined Stimulation2014

    • Author(s)
      中野直樹、中西欣弥、吉岡宏真、村上沙織、田崎貴之、加藤天美、岩倉倫裕
    • Organizer
      第53回日本定位機能外科学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] Combination of GPi and Voa stimulation for Neuroacanthosis.2013

    • Author(s)
      Nakano N, Yoshioka H, Murakami S, Tasaki T, Iwakura N, Nakanishi K, Uchiyama T, Kato A
    • Organizer
      16th quadrennial meeting of the World Society of Stereotactic and Functional Neurosurgery (WSSFN)
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Research-status Report
  • [Presentation] Indication of Vagus Nerve Stimulation and Callosotomy A result in single neurosurgical unit.2013

    • Author(s)
      Nakano N, Yoshioka H, Murakami S, Tasaki T, Iwakura N, Nakanishi K, Ninomiya T, Kato A
    • Organizer
      30th International Epilepsy Congress
    • Place of Presentation
      Montraeal
    • Related Report
      2013 Research-status Report
  • [Presentation] 当院での迷走神経刺激術の効果2013

    • Author(s)
      中野直樹、吉岡宏真、村上沙織、田崎貴之、加藤天美、岩倉倫裕
    • Organizer
      第47回日本てんかん学会
    • Place of Presentation
      北九州
    • Related Report
      2013 Research-status Report
  • [Presentation] 迷走神経刺激術の適応と経過2013

    • Author(s)
      中野直樹、吉岡宏真、村上沙織、田崎貴之、加藤天美、岩倉倫裕
    • Organizer
      第72回日本脳神経外科学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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