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Plastic changes in cutaneous reflexes in the lower limb muscles following high-frequency electrical stimulation to the sole, and their application to induce modulation of the walking cycle

Research Project

Project/Area Number 25350701
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionChiba University

Principal Investigator

KOMIYAMA Tomoyoshi  千葉大学, 教育学部, 教授 (70215408)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords皮膚反射 / 足底部 / 立位 / 歩行 / 歩行周期 / 可塑的変化 / 電気刺激 / 歩行運動 / 部位依存性 / 歩行周期依存性 / ヒト / 高頻度電気刺激 / 可塑性 / 下肢筋
Outline of Final Research Achievements

The present study investigated the effect of high-frequency (333 Hz) and sustained (200 ms) electrical stimulation (HFES) to a given sole region during standing and walking. Also, location-dependent cutaneous reflexes were investigated during walking. During standing, inhibitory cutaneous reflexes in the ankle flexor muscles following the HFES of a given sole region were attenuated for ~30 min. During walking, forefoot medial (f-M) in the sole induced facilitation during stance to swing transition phases, but heel (HL) stimulation evoked suppression during the late stance to the end of swing phases. After delivering HFES to f-M or HL for 10 min at the stance to swing transition phase during walking, cycle duration of walking was prolonged or shortened, respectively. Both changes in cycle duration were retained for ~20 min. These findings suggest that HFES to specific sole regions a given walking phase can induce plastic changes in walking cycle duration.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (37 results)

All 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (16 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 15 results,  Acknowledgement Compliant: 7 results,  Open Access: 3 results) Presentation (16 results) (of which Int'l Joint Research: 3 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] University of Victoria(Canada)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] History-dependent changes in the recovery process of the middle latency cutaneous reflex gain after ankle sprain injury.2016

    • Author(s)
      Futatsubashi G, Sasada S, Ohtsuka H, Suzuki S, Komiyama T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 116 Issue: 3 Pages: 459-470

    • DOI

      10.1007/s00421-015-3292-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Common neural element receiving rhythmic arm and leg activity as assessed by reflex modulation in arm muscles.2016

    • Author(s)
      S. Sasada, T. Tazoe, T. Nakajima, G. Futatsubashi, H. Ohtsuka, S. Suzuki, E.P. Zehr, and T. Komiyama
    • Journal Title

      Journal of Neurophysiology.

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Soleus Hoffmann reflex amplitudes are specifically modulated by cutaneous inputs from the arms and opposite leg during walking but not standing.2016

    • Author(s)
      S. Suzuki, T. Nakajima, G. Futatsubashi, R.A. Mezzarane, H. Ohtsuka, Y. Ohki, E.P. Zehr, and T. Komiyama
    • Journal Title

      Experimental Brain Research

      Volume: 未定 Issue: 8 Pages: 2293-2304

    • DOI

      10.1007/s00221-016-4635-3

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neural mechanisms underlying reversal of cutaneous reflexes during human bipedal walking2016

    • Author(s)
      Tsuyoshi Nakajima, Shinya Suzuki, Genki Futatsubashi, Hiroyuki Ohtsuska2,4, Rinaldo A. Mezzarane, Trevor S. Barss, Taryn Klarner, E. Paul Zehr and Tomoyoshi Komiyama
    • Journal Title

      Journal of Neurophysiology

      Volume: In press Issue: 1 Pages: 1-25

    • DOI

      10.1152/jn.01011.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Reflex control of human locomotion: Existence, features and functions of common interneuronal system induced by multiple sensory inputs in humans2015

    • Author(s)
      T. Nakajima,R.A. Mezzarane, T. Komiyama, and E.P. Zehr
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 4 Issue: 2 Pages: 197-211

    • DOI

      10.7600/jpfsm.4.197

    • NAID

      130005073621

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2015 Annual Research Report
  • [Journal Article] Phase-dependent reversal of the crossed conditioning effect on the soleus Hoffmann reflex from cutaneous afferents during walking in humans.2015

    • Author(s)
      S. Suzuki, T. Nakajima, G. Futatsubashi, R.A. Mezzarane, H. Ohtsuka, Y. Ohki, and T. Komiyama
    • Journal Title

      Experimental Brain Research

      Volume: 234(2) Issue: 2 Pages: 617-626

    • DOI

      10.1007/s00221-015-4463-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Leg automaticity is stronger than arm automaticity during simultaneous arm and leg cycling.2014

    • Author(s)
      Sakamoto M, Tazoe T, Nakajima T, Endoh T, Shiozawa S, Komiyama T.
    • Journal Title

      Neuroscience Letters

      Volume: 654 Pages: 62-66

    • DOI

      10.1016/j.neulet.2014.02.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergence in Reflex Pathways from Multiple Cutaneous Nerves Innervating the Foot Depends upon the Number of Rhythmically Active Limbs during Locomotion.2014

    • Author(s)
      Nakajima T, Mezzarane RA, Hundza SR, Komiyama T, Zehr EP.
    • Journal Title

      PLoS One.

      Volume: 29;9(8): Issue: 8 Pages: e104910-e104910

    • DOI

      10.1371/journal.pone.0104910

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Volitional walking via upper limb muscle-controlled stimulation of the lumbar locomotion center in man.2014

    • Author(s)
      Sasada S, Kato K, Kdowaki S, Groiss SJ, Ugawa Y, Komiyama T, Nishimura Y
    • Journal Title

      J Neurosci,

      Volume: 34 Issue: 33 Pages: 11131-11142

    • DOI

      10.1523/jneurosci.4674-13.2014

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cutaneous stimulation of discrete regions of the sole during locomotion produces "sensory steering" of the foot.2014

    • Author(s)
      Zehr EP, Nakajima T, Barss T, Klarner T, Miklosovic S, Mezzarane RA, Nurse M, Komiyama T.
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 6 Issue: 1 Pages: 33-33

    • DOI

      10.1186/2052-1847-6-33

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Number of previous ankle sprains a latent risk factor for recurrent ankle sprain in young soccer players2014

    • Author(s)
      Genki Futatsubashi, Syusaku Sasada, Hiroyuki Ohtsuka, Tomoyoshi Komiyama
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 3 Issue: 1 Pages: 139-145

    • DOI

      10.7600/jpfsm.3.139

    • NAID

      130003397899

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms influencing interlimb coordination during locomotion in humans: presynaptic modulation of forearm H-reflexes during leg cycling.2013

    • Author(s)
      Nakajima T, Mezzarane RA, Klarner T, Barss TS, Hundza SR, Komiyama T, Zehr EP.
    • Journal Title

      PLoS One

      Volume: 18 Issue: 10 Pages: 1-9

    • DOI

      10.1371/journal.pone.0076313

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amplification ofinterlimb reflexes evoked bystimulating the hand simult aneouslywith conditioning from the foot duringlocomotion2013

    • Author(s)
      Nakajima T, Barss T, Klarner T,Komiyama T., Zehr EP
    • Journal Title

      BMC Neurosci

      Volume: 13;14 Issue: 1 Pages: 28-28

    • DOI

      10.1186/1471-2202-14-28

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gain modulation of the middle latency cutaneous reflex in patients with chronic joint instability after ankle sprain2013

    • Author(s)
      Futatsubashi G, Sasada S, Tazoe T, Komiyama T
    • Journal Title

      Clinical Neurophysiology

      Volume: (印刷中) Issue: 7 Pages: 1406-1416

    • DOI

      10.1016/j.clinph.2013.01.029

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of interhemispheric interactions across symmetric and asymmetric bimanual force regulations2013

    • Author(s)
      Tazoe T, Sasada S, Sakamoto M, Komiyama T
    • Journal Title

      European Journal of Neuroscience

      Volume: 37 Issue: 1 Pages: 96-104

    • DOI

      10.1111/ejn.12026

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Modulation of homosynaptic depression during voluntary contraction and muscle fatigue with different test reflex size2013

    • Author(s)
      Rei Takahashi, Takashi Endoh, Tsuyoshi Nakajima, Tomoyoshi Komiyama
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 2 Issue: 2 Pages: 251-258

    • DOI

      10.7600/jpfsm.2.251

    • NAID

      10031159046

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Restoring walking ability in individuals with severe spinal cord injury using a closed-loop spinal magnetic stimulation2015

    • Author(s)
      Y. NAKAO, S. SASADA, K. KATO, T. MURAYAMA, S. KADOWAKI, S. YOSHIDA, M. IIZUKA, T. KOMIYAMA, Y. UGAWA, and Y. NISHIMURA
    • Organizer
      Society for Neurosceince 2015
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Topographic organization of responses evoked by discrete cutaneous stimulation of the foot dorsum during locomotion.2015

    • Author(s)
      G.E. PEARCEY, T. KLARNER, T.S. BARSS, Y. SUN Y, C. KAUPP, T. NAKAJIMA, T. KOMIYAMA, B. MUNRO, and E.P. ZEHR
    • Organizer
      Society for Neurosceince 2015
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Galvanic vestibular stimulation is available to induce long-term potentiation of indirect cortico-motoneuronal excitation in a relaxed arm muscle in humans.2015

    • Author(s)
      S. SUZUKI, T. NAKAJIMA, S. IRIE, Y. MASUGI, T. KOMIYAMA, and Y. OHKI Y.
    • Organizer
      Society for Neurosceince 2015
    • Place of Presentation
      Chicago(USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 足関節捻挫受傷頻度の違いに伴う神経生理学的回復過程の変化.2015

    • Author(s)
      38.二橋元紀・笹田周作・大塚裕之・鈴木伸弥・小宮山伴与志
    • Organizer
      第70回日本体力医学会大会
    • Place of Presentation
      和歌山県民文化会館(和歌山県、和歌山市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plastic changes in inhibitory effect on indirect cortico-motoneuonal pathways in humans.2015

    • Author(s)
      T. Nakajima, S. Suzuki, G. Futatsubashi, S. Irie, T. Komiyama, and Y. Ohki
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議(兵庫県、神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inducing long-term potentiation of indirect cortico-motoneuronal excitation in relaxed arm muscle by utilizing vestibular stimulation in humans.2015

    • Author(s)
      S. Suzuki, T. Nakajima, S. Irie, Y. Masugi, T. Komiyama, and Y. Ohki
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議(兵庫県、神戸市)
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasticity of indirect cortico-motoneuronal excitations in relaxed hand muscles in humans2014

    • Author(s)
      T. NAKAJIMA, S. SUZUKI, H. OHTSUKA, T. ENDOH, Y. MASUGI, S. IRIE, T. KOMIYAMA, Y. OHKI
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Phase-dependent cutaneous reflex reversal during walking emerges from reflex signs produced by afferents in discrete foot sole regions2014

    • Author(s)
      T. KOMIYAMA, T. NAKAJIMA, E. P. ZEHR, S. SUZUKI, R. A. MEZZARANE, H. OHTSUKA, G. FUTATSUBASHI, T. KLARNER, T. S. BARSS
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Limb-specific control of interlimb reflex transmission during walking in humans2014

    • Author(s)
      S. SUZUKI, T. NAKAJIMA, G. FUTATSUBASHI, R. A. MEZZARANE, H. OHTSUKA, T. KOMIYAMA
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      Washington, DC(USA)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 脊椎上磁気刺激がバイタルサインにたいする影響2014

    • Author(s)
      西村 幸男,笹田 周作,門脇 傑,加藤 健治,八尾 弥起,村山 尊司,吉田 晋,飯塚 正之,小宮山 伴与志,宇川 義一
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] 脊髄損傷後の人工神経接続による下肢歩行運動の随意制御2014

    • Author(s)
      笹田 周作,加藤 健治,中尾 弥起,村山 尊司,門脇 傑,吉田 晋,飯塚 正之,小宮山 伴与志,宇川 義一,西村 幸男
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] ヒトにおける歩行中の四肢間反射の刺激肢特異性.2014

    • Author(s)
      鈴木伸弥, 中島剛, 二橋元紀, 大塚裕之, 小宮山伴与志.
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川、横浜)
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Neural modules for walking in human lumbar spinal cord

    • Author(s)
      S. SASADA, K. KATO, S. KADOWAKI, T. KOMIYAMA, Y. UGAWA Y. NISHIMURA
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Different conditioning effect of contralateral H-reflex during walking and standing

    • Author(s)
      S. SUZUKI, T. NAKAJIMA, R. A. MEZZARANE, G. FUTATSUBASHI, H. OHTSUKA, T. KOMIYAMA
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Neuromechanical effects of cutaneous feedback from discrete regions of the foot sole during locomotion

    • Author(s)
      E. ZEHR, T. NAKAJIMA, T. BARSS, T. KLARNER,, S. MIKLOSOVIC, R. MEZZARANE, M. NURSE, T. KOMIYAMA;
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Timing- and activity- dependent plasticity of indirect cortico-motoneuronal pathways in humans

    • Author(s)
      T. NAKAJIMA, T. KOMIYAMA, H. OHTSUKA, S. SUZUKI, G. UTATSUBASHI, Y. OHKI
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Research-status Report
  • [Book] ニュー運動生理学Ⅰ(宮村実晴編)、Section 1、反射性制御と可塑性2014

    • Author(s)
      小宮山伴与志
    • Total Pages
      10
    • Publisher
      真興交易医書出版部
    • Related Report
      2014 Research-status Report
  • [Book] 歩行と走行の脳・神経科学 -その基礎から臨床まで-第4章歩行・走行と脊髄反射、pp47-552013

    • Author(s)
      小宮山伴与志著、 大築、鈴木、柳原編
    • Total Pages
      232
    • Publisher
      市村出版
    • Related Report
      2013 Research-status Report
  • [Remarks] 千葉大学教育学部、教員一覧DB

    • URL

      http://www.education.chiba-u.jp/index.php?active_action=multidatabase_view_main_detail&content_id=245&multidatabase_id=7&block_id=953#

    • Related Report
      2015 Annual Research Report
  • [Remarks] データベース-千葉大学教育学部

    • URL

      http://www.education.chiba-u.jp/index.php?active_action=multidatabase_view_main_detail&content_id=245&multidatabase_id=7&block_id=953#

    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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