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Brain stimulation associated to motor skill learning

Research Project

Project/Area Number 25350815
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionHiroshima University

Principal Investigator

Funase Kozo  広島大学, 総合科学研究科, 教授 (40173512)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsスポーツ科学 / 経頭蓋磁気刺激 / 一次運動野 / 興奮性 / 動作スキル学習 / 運動パフォーマンス / 末梢神経刺激 / 一次運動野興奮性
Outline of Final Research Achievements

First, we found that the number of repetitive practices of post-learning of visual tracking task which requires the error correction is strongly related to the changes in motor cortex (M1) excitability and the retention of the motor learning. Second, we investigated the effect of intervention using an invasive brain stimulation, paired associative simulation (PAS), on the maximum voluntary contraction (MVC) and the maximum acceleration during ballistic abduction movement of an index finger. temporal increase of motor evoked potential (MEP) amplitude after PAS intervention was confirmed, and also, temporal increase of MVC was detected. However, the maximum acceleration was not affected by the PAS intervention. It is suggested that the intervention using an invasive brain stimulation possibely affects the fundamental motor performance.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (57 results)

All 2015 2014 2013 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results,  Acknowledgement Compliant: 4 results,  Open Access: 3 results) Presentation (32 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (7 results)

  • [Journal Article] Patterned sensory nerve stimulation enhances the reactivity of spinal Ia inhibitory interneurons2015

    • Author(s)
      Shinji Kubota, Masato Hirano, Takuya Morishita, Kazumasa Uehara, Kozo Funase
    • Journal Title

      Neuroreport

      Volume: 26 Issue: 5 Pages: 249-253

    • DOI

      10.1097/wnr.0000000000000335

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Excitability changes in the left primary motor cortex innervating the hand muscles induced during speech about hand or leg movements2015

    • Author(s)
      Yusuke Onmyoji, Shinji Kubota, Masato Hirano, Megumi Tanaka, Takuya Morishita, Kazumasa Uehara, Kozo Funase
    • Journal Title

      Neuroscience Letters

      Volume: 594 Pages: 46-50

    • DOI

      10.1016/j.neulet.2015.03.052

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of tactile stimulation on primary motor cortex excitability during action observation combined with motor imagery2015

    • Author(s)
      Tanaka M, Kubota S, Onmyoji Y, Hirano M, Uehara K, Morishita T, Funase K
    • Journal Title

      Neuroscience Letters

      Volume: 600 Pages: 1-5

    • DOI

      10.1016/j.neulet.2015.05.057

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interactions Among Learning Stage, Retention, and Primary Motor Cortex Excitability in Motor Skill Learning2015

    • Author(s)
      Masato Hirano, Shinji Kubota, Shigeo Tanabe, Yoshiki Koizume, Kozo Funase
    • Journal Title

      Brain Stimulation

      Volume: 8 Issue: 6 Pages: 1195-1204

    • DOI

      10.1016/j.brs.2015.07.025

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in the spinal neural circuits are dependent on the movement speed of the visuomotor task.2015

    • Author(s)
      Kubota S, Hirano M, Koizume Y, Tanabe S, Funase K.
    • Journal Title

      Frontiers in Human Neuroscience.

      Volume: 9 Pages: 1-14

    • DOI

      10.3389/fnhum.2015.00667

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Long-term practice induced plasticity in the primary motor cortex innervating the ankle flexor in football juggling experts2014

    • Author(s)
      Hirano M, Kubota S, Morishita T, Uehara K, Fujimoto S, Funase K
    • Journal Title

      Motor Control,

      Volume: 18 Issue: 3 Pages: 310-321

    • DOI

      10.1123/mc.2013-0059

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 感覚入力方法の違いが脊髄反射回路の活動変化に及ぼす影響について-末梢神経電気刺激と筋振動刺激による比較-2014

    • Author(s)
      窪田 慎治, 平野 雅人, 守下卓也, 上原 一将, 船瀬 広三
    • Journal Title

      物理療法科学

      Volume: 21 Pages: 32-39

    • Related Report
      2014 Research-status Report
  • [Journal Article] Unilateral imagined movement increases interhemispheric inhibition from the contralateral to ipsilateral motor cortex2014

    • Author(s)
      Liang N, Funase K, Takahashi M, Matsukawa K, Kasai T
    • Journal Title

      Exp Brain Res

      Volume: 232 Issue: 6 Pages: 1823-1832

    • DOI

      10.1007/s00221-014-3874-4

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contribution of ipsilateral primary motor cortex activity to the execution of voluntary movements in humans: A review of recent studies2014

    • Author(s)
      Uehara K, Funase K
    • Journal Title

      The Journal of Physical Fitness and Sports Medicine

      Volume: 3 Issue: 3 Pages: 297-306

    • DOI

      10.7600/jpfsm.3.297

    • NAID

      130004972978

    • ISSN
      2186-8123, 2186-8131
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Different modulation of short- and long-latency interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task2014

    • Author(s)
      Takuya Morishita, Shinji Kubota, Masato Hirano, Kozo Funase
    • Journal Title

      Physiological Reports

      Volume: 2(10) Issue: 10 Pages: 1-14

    • DOI

      10.14814/phy2.12170

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional difference in short- and long-latency interhemispheric inhibiti on from active to resting hemisphere during a unilateral muscle contraction2014

    • Author(s)
      Kazumasa Uehara, Takuya Mori shita, Shinji Kubota, Masato Hirano, Kozo Funase
    • Journal Title

      Journal of Neurophysiology

      Volume: 111 Issue: 1 Pages: 17-25

    • DOI

      10.1152/jn.00494.2013

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inter-individual variation in reciprocal Ia inhibition is dependent on the descending volleys delivered from corticospinal neurons to Ia interneurons2014

    • Author(s)
      Kubota S, Uehara K, Morishita T, Hirano M, Funase K
    • Journal Title

      Journal of Electromyography and Kinesiology

      Volume: 24 Issue: 1 Pages: 46-51

    • DOI

      10.1016/j.jelekin.2013.11.004

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-term practice induced plasticity in the primary motor cortex innervating the ankle flexor in football juggling experts2014

    • Author(s)
      Hirano M, Kubota S, Morishita T, Uehara K, Fujimoto S, Funase K
    • Journal Title

      Motor Control

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感覚入力方法の違いが脊髄反射回路の活動変化に及ぼす影響について: 末梢神経電気刺激と筋振動刺激による比較2014

    • Author(s)
      窪田 慎治, 平野 雅人, 守下 卓也, 上原 一将, 船瀬 広三
    • Journal Title

      日本物理療法学会学会誌

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neural mechanisms underlying the changes in ipsilateral primary motorcortex excitability during unilateral rhythmic muscle contraction2013

    • Author(s)
      Kazumasa Uehara, Takuya Morishita, Shinji Kubota, Kozo Funase
    • Journal Title

      Behavioural Brain Research

      Volume: 240 Pages: 33-45

    • DOI

      10.1016/j.bbr.2012.10.053

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in the ipsilateral motor cortex excitability is independent fiom a muscle contraction phase during unilateral repetitive isometric contractions2013

    • Author(s)
      Kazumasa Uehara, Takuya Morishita, Shinji Kubota, Kozo Funase
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 1 Pages: e55083-e55083

    • DOI

      10.1371/journal.pone.0055083

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asymmetry of interhemispheric inhibition from active to resting primary motor cortex induced by a fine-motor maipulation task of either dominant or non-dominant hand2013

    • Author(s)
      Morishita T, Uehara K, Kubota S, Funase K
    • Journal Title

      Advances in Exercise and Sports Physiology

      Volume: 19 Pages: 15-24

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in the ipsilateral motor cortex excitability induced by different frequencies of afferent inputs in healthy subjects: a TMS study2013

    • Author(s)
      Uehara K, Morishita T, Kubota S, Hirano M, Funase K
    • Journal Title

      Advances in Exercise and Sports Physiology

      Volume: 19 Pages: 61-72

    • NAID

      110009673900

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 運動学習に伴う short-latency afferent inhibition の変化2015

    • Author(s)
      小井詰喜希,窪田慎治, 平野雅人,田辺茂雄,船瀬広三
    • Organizer
      第45回日本臨床神経生理学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] The effect of movement speed of visuomotor task on the activity of spinal inhibitory circuits2015

    • Author(s)
      Kubota S, Hirano K, Koizume Y, Tanabe S, Funase K
    • Organizer
      Neuroscience 2015, Society for Neuroscience
    • Place of Presentation
      Chicago USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 律動性 visuomotor 課題における足関節運動速度の違いに依存した脊髄反射回路の活動性変化2015

    • Author(s)
      窪田慎治, 平野雅人, 小井詰喜希, 船瀬広三
    • Organizer
      第23回日本運動生理学会
    • Place of Presentation
      日本体育大学
    • Year and Date
      2015-07-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 律動性 visuomotor 課題後にみられるシナプス前抑制量の変化2015

    • Author(s)
      窪田 慎治, 平野 雅人, 小井詰喜希, 田辺茂雄, 船瀬 広三
    • Organizer
      第9回 Motor Control 研究会
    • Place of Presentation
      京都大学
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Relationship between intrinsic intracortical inhibition and rate of motor skill learning2015

    • Author(s)
      Koizume Y, Hirano M, Kubota s, Tanabe S, Funase K
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore Expo Convention and Exhibition Centre
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Change in M1 excitability occur during the slow-learning stage of motor skill learning2015

    • Author(s)
      Hirano M, Kubota s, Tanabe S, Koizume Y, Funase K
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore Expo Convention and Exhibition Centre
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] Movement speed-dependent modulation on the activity of spinal inhibitory circuits2015

    • Author(s)
      Kubota S, Hirano M, Koizume Y, Tanabe S, Funase K
    • Organizer
      1st International Brain Stimulation Conference
    • Place of Presentation
      Singapore Expo Convention and Exhibition Centre
    • Year and Date
      2015-03-02 – 2015-03-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動学習における学習段階と一次運動野興奮性の関連性2014

    • Author(s)
      平野 雅人, 窪田 慎治, 小井詰喜希, 田辺茂雄, 船瀬 広三
    • Organizer
      第44回日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] シナプス前抑制回路が律動性関節運動パフォーマンスに及ぼす影響について2014

    • Author(s)
      窪田 慎治, 平野 雅人, 小井詰喜希, 田辺茂雄, 船瀬 広三
    • Organizer
      第44回日本臨床神経生理学会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-19 – 2014-11-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Long-term practice induced plasticity in the primary motor cortex innervating the ankle flexor in football juggling experts2014

    • Author(s)
      平野 雅人
    • Organizer
      平成26年度広島体育学会研究発表例会
    • Place of Presentation
      広島大学東千田キャンパス
    • Year and Date
      2014-10-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Interhemispheric interaction と随意運動の関係について2014

    • Author(s)
      上原 一将
    • Organizer
      第31回筋電図の会
    • Place of Presentation
      長崎大学
    • Year and Date
      2014-09-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 運動学習によって生じるM1興奮性変化の個人差について2014

    • Author(s)
      平野 雅人, 窪田 慎治, 船瀬広三
    • Organizer
      第22回日本運動生理学会
    • Place of Presentation
      川崎医療福祉大学
    • Year and Date
      2014-07-19 – 2014-07-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 脊髄Ia抑制性介在ニューロンに対する下行性および上行性入力の影響2014

    • Author(s)
      窪田 慎治
    • Organizer
      第28回ヒトの随意運動制御研究会
    • Place of Presentation
      川崎医療福祉大学
    • Year and Date
      2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] 動作イメージを伴う他者の把持動作観察時の手指筋支配M1興奮性に対する指尖体性感覚刺激の影響について2014

    • Author(s)
      田中 恩, 上原 一将, 窪田慎治, 隠明寺 悠介, 守下 卓也, 平野雅人, 船瀬広三
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 手と脚動作に関する文章発声時の左大脳皮質一次運動野の興奮性変化と皮質内抑制回路2014

    • Author(s)
      隠明寺 悠介, 窪田慎治, 田中恩, 平野 雅人, 上原 一将, 守下卓也, 船瀬広三
    • Organizer
      第49回日本理学療法学術大会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Plasticity in primary motor cortex innervating the ankle flexor in football juggling experts2014

    • Author(s)
      Hirano M, Kubota S, Morishita T, Uehara K, Funase K
    • Organizer
      30th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Excitability changes in spinal reciprocal inhibitory circuit induced by periodical sensory inputs2014

    • Author(s)
      Kubota S, Hirano M, Morishita T, Uehara K, Funase K
    • Organizer
      30th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] Different modulation of short- and long-latency interhemispheric inhibition from active to resting primary motor cortex during a fine-motor manipulation task2014

    • Author(s)
      Morishita T, Kubota S, Hirano M, Funase K
    • Organizer
      30th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] A comparison between short and long latency interhemispheric inhibition from the active to resting primary motor cortex during a unilateral muscle contraction2014

    • Author(s)
      Uehara K, Morishita T, Kubota S, Hirano M, Funase K
    • Organizer
      30th International Congress of Clinical Neurophysiology
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Research-status Report
  • [Presentation] 他者の把持動作観察時における体性感覚刺激が手指筋支配M1興奮性に及ぼす影響2013

    • Author(s)
      田中 恩, 上原 一将, 窪田慎治, 隠明寺 悠介, 守下 卓也, 藤本 周策, 平野 雅人, 船瀬広三
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 手と脚に関する動詞発声時の左大脳皮質一次運動野の興奮性変化2013

    • Author(s)
      隠明寺 悠介, 上原 一将, 窪田慎治, 田中 恩, 守下 卓也, 平野 雅人, 藤本 周策, 船瀬広三
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] 脊髄相反抑制量と皮質脊髄路及び脊髄運動ニューロン興奮性の関係性について2013

    • Author(s)
      窪田 慎治, 上原 一将, 守下卓也, 隠明寺 悠介, 田中 恩, 平野 雅人, 藤本 周策, 船瀬広三
    • Organizer
      第48回日本理学療法学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Research-status Report
  • [Presentation] Sensorimotor課題遂行時における半球間抑制回路の変化2013

    • Author(s)
      守下 卓也
    • Organizer
      第27回ヒトの随意運動制御研究会
    • Place of Presentation
      川越
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] ボールリフティング熟練者における前脛骨筋支配一次運動野の可塑的変化について2013

    • Author(s)
      平野 雅人, 窪田 慎治, 守下卓也, 上原 一将, 船瀬 広三
    • Organizer
      第21回日本運動生理学会
    • Place of Presentation
      川越
    • Related Report
      2013 Research-status Report
  • [Presentation] 周期的な感覚刺激が脊髄相反抑制回路に与える影響2013

    • Author(s)
      窪田慎治, 平野雅人, 守下卓也, 上原一将, 船瀬広三
    • Organizer
      第21回日本運動生理学会
    • Place of Presentation
      川越
    • Related Report
      2013 Research-status Report
  • [Presentation] Sensorimotor課題遂行後の同側運動野の興奮性変化2013

    • Author(s)
      守下 卓也, 上原 一将, 窪田慎治, 平野 雅人, 船瀬 広三
    • Organizer
      第21回日本運動生理学会
    • Place of Presentation
      川越
    • Related Report
      2013 Research-status Report
  • [Presentation] 電気生理学を基礎とした運動制御研究の進展2013

    • Author(s)
      守下 卓也
    • Organizer
      第21回日本運動生理学会
    • Place of Presentation
      川越
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Paired associative stimulation効果の個人差と皮質内抑制回路2013

    • Author(s)
      船瀬 広三, 藤本 周策, 平野 雅人, 窪田 慎治, 守下 卓也, 上原 一将, 隠明寺悠介, 田中 恩
    • Organizer
      第21回日本物理療法学会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Research-status Report
  • [Presentation] 末梢への物理的刺激が脊髄運動ニューロン興奮性変化に与える影響について2013

    • Author(s)
      窪田 慎治, 平野 雅人, 守下 卓也, 上原 一将, 船瀬 広三
    • Organizer
      第21回日本物理療法学会
    • Place of Presentation
      横須賀
    • Related Report
      2013 Research-status Report
  • [Presentation] 手および脚の運動に関する文章発声時の左大脳皮質一次運動野の興奮性変化2013

    • Author(s)
      隠明寺 悠介, 窪田 慎治, 田中恩, 平野 雅人, 守下 卓也, 上原 一将, 船瀬 広三
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] 長期トレーニングが前脛骨筋支配一次運動野の興奮性に及ぼす影響2013

    • Author(s)
      平野 雅人, 窪田 慎治, 守下卓也, 上原 一将, 船瀬 広三
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Presentation] 末梢からの感覚入力に伴う脊髄反射回路の活動性変化について2013

    • Author(s)
      窪田 慎治, 平野 雅人, 守下卓也, 上原 一将, 船瀬 広三
    • Organizer
      第43回日本臨床神経生理学会
    • Place of Presentation
      高知
    • Related Report
      2013 Research-status Report
  • [Remarks] 広島大学大学院総合科学研究科運動神経生理学研究室

    • URL

      http://home.hiroshima-u.ac.jp/funase/index1.htm

    • Related Report
      2015 Annual Research Report
  • [Remarks] 上達後も繰り返し練習することで運動スキルを保持する能力も高くなる

    • URL

      http://www.hiroshima-u.ac.jp/news/show/id/23835

    • Related Report
      2015 Annual Research Report
  • [Remarks] 広島大学HP英語版

    • URL

      http://www.hiroshima-u.ac.jp/news/show/lang/en/id/2013

    • Related Report
      2015 Annual Research Report
  • [Remarks] AlphaGalileo

    • URL

      http://www.alphagalileo.org/ViewItem.aspx?ItemId=161996&CultureCode=en

    • Related Report
      2015 Annual Research Report
  • [Remarks] 広島大学HP英語版

    • URL

      http://www.hiroshima-u.ac.jp/news/show/lang/en/id/2012

    • Related Report
      2015 Annual Research Report
  • [Remarks] 広島大学大学院総合科学研究科身体運動科学研究領域 Human Motor Control 研究室

    • URL

      http://home.hiroshima-u.ac.jp/funase/index1.htm

    • Related Report
      2014 Research-status Report
  • [Remarks] 広島大学総合科学研究科運動神経生理学 Human Motor Control 研究室

    • URL

      http://home.hiroshima-u.ac.jp/funase/index1.htm

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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