Functional role of hypothalamic dopamine on improvement of exercise capacity
| Project/Area Number |
25350816
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 持久性運動 / 体温 / 視床下部 / ドーパミン / 持久性運動能力 / 持久的運動 / カフェイン |
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| Outline of Final Research Achievements |
The purpose of present study is to investigate the functional role of hypothalamic dopaminergic neuronal activity on improvement of exercise capacity in the rat. The inhibition of brain dopamine by dopamine D1 antagonist influenced endurance exercise capacity and body temperature. The administration of caffeine increased the exercise capacity, core temperature and extracellular dopamine release in the hypothalamus. Blockage of dopaminergic neurotransmission by pre-treatment with a dopamine receptor antagonist prevented caffeine-induced increases in the exercise capacity. These new findings suggest that the dopamine in the hypothalamus play an important role of exercise-induced hyperthermia and fatigue.
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Report
(4 results)
Research Products
(17 results)
