Functional role of hypothalamic dopamine on improvement of exercise capacity

• Project/Area Number: 25350816
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Hiroshima University
• Principal Investigator: Hasegawa Hiroshi 広島大学, 総合科学研究科, 教授 (70314713)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 持久性運動 / 体温 / 視床下部 / ドーパミン / 持久性運動能力 / 持久的運動 / カフェイン

Outline of Final Research Achievements

The purpose of present study is to investigate the functional role of hypothalamic dopaminergic neuronal activity on improvement of exercise capacity in the rat. The inhibition of brain dopamine by dopamine D1 antagonist influenced endurance exercise capacity and body temperature. The administration of caffeine increased the exercise capacity, core temperature and extracellular dopamine release in the hypothalamus. Blockage of dopaminergic neurotransmission by pre-treatment with a dopamine receptor antagonist prevented caffeine-induced increases in the exercise capacity. These new findings suggest that the dopamine in the hypothalamus play an important role of exercise-induced hyperthermia and fatigue.

Research Products

• [Journal Article] Administration of caffeine inhibited adenosine receptor agonistinduced decreases in motor performance, thermoregulation, and brain neurotransmitter release in exercising rats (2015)
  • Author(s): Zheng, X., Hasegawa, H.
  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 140 Pages: 82-89
  • DOI: 10.1016/j.pbb.2015.10.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Central dopaminergic neurotransmission plays an important role in thermoregulation and performance during endurance exercise (2015)
  • Author(s): Zheng, X., Hasegawa, H
  • Journal Title: European Journal of Sport Science Volume: 19 Issue: 7 Pages: 1-11
  • DOI: 10.1080/17461391.2015.1111938
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 暑熱環境下の運動パフォーマンス低下と暑さ対策の重要性 (2015)
  • Author(s): 長谷川博
  • Journal Title: トレーニング科学 Volume: 26 Pages: 121-125
• [Journal Article] スポーツ活動時の実践的暑さ対策とリカバリー (2015)
  • Author(s): 長谷川博
  • Journal Title: 月刊スポーツメディスン Volume: 27 Pages: 14-23
• [Journal Article] Acute intraperitoneal injection of caffeine improves endurance exercise performance in association with increasing brain dopamine release during exercise (2014)
  • Author(s): Zheng X, Takatsu S, Wang H, Hasegawa H.
  • Journal Title: Pharmacology, Biochemistry and Behavior Volume: 122 Pages: 136-143
  • DOI: 10.1016/j.pbb.2014.03.027
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] The activation of adenosine receptors inhibited caffeine-affected exercise performance, thermoregulation and brain neurotransmission. (2015)
  • Author(s): Zheng X, Hasegawa H.
  • Organizer: 20th Annual Congress of European College of Sports Science
  • Place of Presentation: Malmo, Sweden
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] カフェインによる脳内ドーパミンの増大が持久的運動能力及び体温調節反応に及ぼす影響 (2014)
  • Author(s): 鄭 シンエン，長谷川 博.
  • Organizer: 第69回日本体力医学会
  • Place of Presentation: 長崎県
  • Year and Date: 2014-09-18 – 2014-09-21
• [Presentation] 高体温による運動能力の低下と暑さ対策戦略 (2014)
  • Author(s): 長谷川 博， 鄭 シンエン，鬼塚純玲.
  • Organizer: 温熱生理研究会2014
  • Place of Presentation: 愛知県
  • Year and Date: 2014-08-28 – 2014-08-29
  • Invited
• [Presentation] Exercise performance in the heat: Possible fluid and cooling strategies (2014)
  • Author(s): Hasegawa H.
  • Organizer: 2014 Incheon Asian Games International Sport Science Congress
  • Place of Presentation: Korea
  • Year and Date: 2014-08-20 – 2014-08-22
  • Invited
• [Presentation] 高体温に伴う運動能力低下のメカニズム (2014)
  • Author(s): 長谷川 博.
  • Organizer: 第22回日本運動生理学会
  • Place of Presentation: 岡山県
  • Year and Date: 2014-07-19 – 2014-07-21
  • Invited
• [Presentation] 運動能力向上における視床下部内ドーパミンの機能的役割 (2014)
  • Author(s): 長谷川 博.
  • Organizer: 第22回日本運動生理学会
  • Place of Presentation: 岡山県
  • Year and Date: 2014-07-19 – 2014-07-21
• [Presentation] Dopamine D1 receptor mediates caffeine-influenced exercise performance, thermoregulation and brain neurotransmission (2014)
  • Author(s): Zheng XY, Hasegawa H.
  • Organizer: 19th Annual Congress of European College of Sports Science
  • Place of Presentation: Netherlands
  • Year and Date: 2014-07-02 – 2014-07-05
• [Presentation] 脳内ドーパミンの抑制が温暖環境下における持久的運動能力及び体温調節反応に及ぼす影響 (2013)
  • Author(s): 長谷川 博，奥田亜芸良，鄭シンエン
  • Organizer: 第68回日本体力医学会
  • Place of Presentation: 東京都
• [Presentation] Central dopaminergic neurotransmission plays an important role in the endurance exercise capacity and thermoregulation in a warm environment (2013)
  • Author(s): Zheng X, Okuda A, Hasegawa H
  • Organizer: The 6th Asia-Pacific Conference on Exercise and Sports Science
  • Place of Presentation: 台湾
• [Presentation] 体温調節と運動パフォーマンス (2013)
  • Author(s): 長谷川博
  • Organizer: 第15回日本体力医学会北海道地方会
  • Place of Presentation: 北海道
  • Invited
• [Book] ニュー運動生理学 (2015)
  • Author(s): 長谷川博
  • Total Pages: 10
  • Publisher: 真興交易
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/hasehiro/index.html