Effects of electrical stimulation-induced muscle contraction on bone loss and the role of mechanosensors in bone
| Project/Area Number |
25350829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Niigata University of Health and Welfare |
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Principal Investigator |
TAMAKI Hiroyuki 新潟医療福祉大学, 医療技術学部, 教授 (40253926)
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| Co-Investigator(Kenkyū-buntansha) |
YOTANI Kengo 鹿屋体育大学, スポーツ生命科学系, 講師 (10581142)
ONISHI Hideaki 新潟医療福祉大学, 医療技術学部, 教授 (90339953)
ISHIDO Minenori 大阪工業大学, 工学部, 講師 (80737536)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 電気刺激 / 骨代謝 / 機械的負荷 / 筋収縮 / 骨強度 / 石灰化 / 筋電気刺激 / 不動 / 阻害剤 / 老化 / メカニカルストレス |
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| Outline of Final Research Achievements |
Limb disuse due to denervation causes musculoskeletal atrophy accompanied by a large reduction in bone mass and changes in trabecular architecture.
We determined the effects of direct electrical stimulation (ES)-induced muscle contraction on the histological profiles in atrophied skeletal muscle fibers and bone tissues after denervation.
The main findings of the present study were: (1) direct electrical stimulation (ES, 16mA, 10Hz, for 30min/day) reduced disuse muscle and bone loss at the early stage of disuse atrophy; and (2) streptomycin treatment, which is one of the potent blockers of stretch-activated channels (SACs), did not induce bone loss, but it attenuated the effects of ES-induced muscle force on reducing the loss of disused bone. This experimental evidence suggests that ES-induced muscle contractions can have beneficial effects on bone health in the early stage of disuse bone loss through activation of SACs.
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Report
(4 results)
Research Products
(18 results)
