| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
This study was to verify the effect of monocarboxylate transporter (MCT) expression in the brain as skeletal muscle and its signal factors to increase MCT expression by exercise. A single bout of exercise increased the neuron-specific MCT2 expression level in the brain. Moreover, MCT1 and MCT4 isoforms were increased. Moreover, the signal factors that increase the brain region specific MCT expression level were examined. The results indicated a possibility that brain lactate production and/or brain-derived neurotrophic factor (BDNF) may become a signal factor that increases the MCT2 expression level in brain. These results suggest that MCT2 expression level of the brain is increased by exercise. As a result of this adaptation phenomenon, lactate uptake ability in the neurons is increased, this can be expected that brain function may enhance.
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