Development of a novel nutritional treatment for diabetic retinopathy based on scientific evidence.

• Project/Area Number: 25350873
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kagoshima Prefectural College
• Principal Investigator: ARIMURA EMI 鹿児島県立短期大学, その他部局等, 助教 (40552964)
• Co-Investigator(Kenkyū-buntansha): HORIUCHI MASAHISA 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50264403)
• Co-Investigator(Renkei-kenkyūsha): KAWAGUCHI HIROAKI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (60325777) ; KUCHIWA SATOSHI 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90161637)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 栄養指導 / 食事療法 / 糖尿病 / 糖尿病網膜症 / 食事たんぱく質 / 動物モデル / 遺伝子発現 / レプチン受容体 / 糖尿病性網膜症 / インスリン分泌不全

Outline of Final Research Achievements

There have been several reports that diabetic retinopathy is treated by inhibitors of renin-angiotensin system (RAS).We previously showed that low-protein diet suppressed expression of RAS related genes in control mice.Then, we thought the possibility that the low-protein diet was effective for not only the kidney but also the retina. We examined how dietary protein contents affect diabetic retinopathy caused by type 2 diabetes.
As a result, under the same content of energy and fat, dietary protein content affected expression of the genes related to RAS, astrocyte and microglia.Further examination is necessary to explain the pathophysiological meanings of the alterations of the gene expression.

Research Products

• [Journal Article] Deteriorated glucose metabolism with a high-protein,low-carbohydrate diet in db mice, an animal model of a type 2 diabetes, might be caused by insufficient insulin secretion (2016)
  • Author(s): Emi Arimura,Wijang Pralampita Pulong, Ancha Caesarina Novi Marchianti, Miwa Nakakuma, Masaharu Abe, Miharu Ushikai, Masahisa Horiuchi
  • Journal Title: Eurropean Journal of Nutrition Volume: in press Issue: 1 Pages: 237-246
  • DOI: 10.1007/s00394-015-1075-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 実験研究による解析、食と生活関連疾患（心疾患・脂肪肝・疲労病態） (2015)
  • Author(s): 堀内正久,中熊美和, 有村恵美，牛飼美晴，吉田剛一郎
  • Journal Title: 日本衛生学会誌 Volume: 70 Pages: 110-114
  • Peer Reviewed
• [Journal Article] Voluntary exercise under a food restriction condition decreases blood branched-chain amino acid levels, in addition to improvement of glucose and lipid metabolism, in db mice, animal model of type 2 diabetes (2014)
  • Author(s): Marchianti AC, Arimura E, Ushikai M, Horiuchi M
  • Journal Title: Environ Health Prev Med Volume: 19 Issue: 5 Pages: 339-347
  • DOI: 10.1007/s12199-014-0400-z
  • NAID: 50009312840
  • Peer Reviewed / Open Access
• [Presentation] 食事たんぱく質量が2型糖尿病網膜症へ及ぼす影響～レプチン受容体欠損マウスを用いた検討～ (2016)
  • Author(s): 有村恵美、岡谷秀明、荒木智陽、川口博明、中熊美和、阿部正治、牛飼美晴、和泉博之、堀内正久
  • Organizer: 第19回日本病態栄養学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-01-09
• [Presentation] Deteriorated glucose metabolism with a high-protein,low-carbohydrate diet in db mice, an animal model of a type 2 diabetes, might be caused by insufficient insulin secretion (2015)
  • Author(s): Emi Arimura,Wijang Pralampita Pulong, Ancha Caesarina Novi Marchianti, Miwa Nakakuma, Masaharu Abe, Miharu Ushikai, Masahisa Horiuchi
  • Organizer: 7th Scientific Meeting of the Asian Association for the Study of Diabetes
  • Place of Presentation: Hong Kong Convention and Exhibition Centreｒ
  • Year and Date: 2015-11-21
  • Int'l Joint Research
• [Presentation] 食事中の蛋白質と炭水化物の2型糖尿病病態へ及ぼす影響 (2014)
  • Author(s): 有村恵美
  • Organizer: 第84回日本衛生学会学術総会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2014-05-25 – 2014-05-27
• [Book] カツオ今昔物語 (2015)
  • Author(s): 鹿児島県立短期大学チームカツオづくし
  • Total Pages: 158
  • Publisher: 筑波書房