Analysis of regulatory mechanism for the maintenance of functionality of reserve cells under nutrition starvation
| Project/Area Number |
25350882
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Wagatsuma Akira 東京大学, 情報理工学(系)研究科, 学術支援専門職員 (00347121)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | リザーブ細胞 / 栄養飢餓 / ストレス / 筋萎縮 / 骨格筋幹細胞 / 栄養飢餓ストレス / 筋衛星細胞 |
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| Outline of Final Research Achievements |
Upon serum deprivation, C2C12 culture contains two different subpopulation, multinucleated myotubes and undifferentiated reserve cells, like quiescent satellite cells. Using this cell culture system, we investigated the regulatory mechanism for the maintenance of functionality of reserve cells under nutrition starvation. Reserve cells exhibited more marked tolerance to nutrition starvation than myotubes. Reserve cells did not impair their ability to regulate cell proliferation and differentiation, suggesting the maintenance of their cell functionality.
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Report
(4 results)
Research Products
(17 results)
