Anti-metabolic syndrome study to regulate liver energy metabolism rupture of NASH

• Project/Area Number: 25350886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Okayama University
• Principal Investigator: TAKAYAMA Fusako 岡山大学, 医歯(薬)学総合研究科, 准教授 (10236367)
• Co-Investigator(Kenkyū-buntansha): OKADA Shigeru 岡山大学, 大学院医歯薬学総合研究科, 特命教授, 名誉教授 (20033201)
• Research Collaborator: YOSHII Aya 岡山大学, 薬学部 ; NOMURA Saori 岡山大学, 薬学部 ; MANKURA Mitsumasa くらしき作陽大学, 教授 ; SATO Fumi 池田糖化工業株式会社, 研究室, 研究員 ; TOYODA HiROShi 岡山協立病院, 病理部, 部長 ; WATANABE Ritsuko 岡山協立病院, 病理部, 主任 ; MORI Akitane 岡山大学, 大学院医歯薬学総合研究科, 名誉教授
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ポリアミン / 脂質異常症 / NASH / ミトコンドリア / 慢性炎症 / 酸化/ニトロ化ストレス / エピジェネティック / 鉄過剰 / エピジェネティクス / 酸化ストレス

Outline of Final Research Achievements

Our previous study exhibited Spirulina platensis worked so well in preventing fibrosis and ameliorating fatty liver of an animal model of non-alcoholic steatohepatitis (NASH). The study indicated the role of epigenetic alteration relating the energy metabolism rupture of liver mitochondria in pathological progress of NASH induced by continuously ingesting high fat and sugar diets and high carbohydrate and by intermittent hypoxemia (similar to sleep apnea syndrome). So this study aimed to explore effects of polyamines to profile the mechanism of polyamines on NASH, to provide therapeutic or preventive agents for therapeutic agent for hepatic dyslipidemia including NASH. The mechanisms of actions were investigated to focus on oxidative injuries, inflammatory reactions and lipid metabolism regulations.

Research Products

• [Presentation] Spirulina platensis and its ingredient prevent NASH to attenuate oxidative stress from mitochondrial energy metabolism and chronic inflammation followed by metabolic turnover alteration (2016)
  • Author(s): Saori Nomura, Aya Yoshii, Fusako Takayama, Yasumasa Kodo, Ritsuko Watanabe, Hiroshi Toyoda, Mitsumasa Mankura, Toru Egashira, Hideaki Kabuto, Tomoko Yamanushi, Shigeru Okada, Akitane Mori
  • Organizer: The 89th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: PACIFICO Yokohama, Yokohama, Japan
  • Year and Date: 2016-03-11
• [Presentation] 非アルコール性脂肪性肝炎に対するスピルリナ成分の有効性と栄養エネルギー代謝破綻への影響 (2015)
  • Author(s): 高山房子, 吉井 彩，豊田 博，渡邊 律子, 黄堂 泰昌, 加太 英明, 山主 智子, 万倉三正, 江頭 亨, 森 昭胤, 岡田 茂
  • Organizer: 第68回日本酸化ストレス学会学術集会
  • Place of Presentation: 鹿児島市
  • Year and Date: 2015-06-12
• [Presentation] Spirulina platensis and its ingredient prevent NASH to attenuate oxidative stress from mitochondrial energy metabolism and chronic inflammation followed by metabolic turnover alteration (2014)
  • Author(s): Aya Yoshii, Fusako Takayama, Yasumasa Kodo, Ritsuko Watanabe, Hiroshi Toyoda, Mitsumasa Mankura, Toru Egashira, Hideaki Kabuto, Tomoko Yamanushi, Shigeru Okada, Akitane Mori
  • Organizer: The Oxygen Club California, the 2014 World Congress on Oxidants and Antioxidants In Biology
  • Place of Presentation: The UC Davis Conference Center
  • Year and Date: 2014-05-07 – 2014-05-10
• [Remarks] 研究テーマ_高山 房子
  • URL: http://www.okayama-u.ac.jp/user/therahl/index.html