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Quantification of subchondral bone sclerosisin patient with osteoarthritic knee

Research Project

Project/Area Number 25350892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionYokohama City University

Principal Investigator

AKAMATSU Yasushi  横浜市立大学, 医学部, 准教授 (30348114)

Co-Investigator(Kenkyū-buntansha) KOBAYASHI Hideo  横浜市立大学, 附属病院, 助教 (10645998)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsosteoarthritis / knee / computed tomography / bone morphology / bone density / conputed tomography / bone morphometry / bone mineral density / bone quality / osteosrthritis / osteoporosis
Outline of Final Research Achievements

The trabecular bone structure in the femoral medial and lateral condyle was analyzed using three dimensional computed tomographic images. Fifty knees were enrolled in this study between April 2013 and March 2015. The TRI / 3D-BON (RATOC System Engineering Co., Ltd.) software was used. Apparent bone volume fraction and apparent trabecular thickness in the femoral medial condyle were higher than those in the femoral lateral condyle. Apparent trabecular separation and degree of anisotropy in the femoral medial condyle were lower than in the femoral lateral condyle. Apparent trabecular number was no significant difference between the femoral medial and and lateral condyles.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (15 results) (of which Invited: 1 results)

  • [Journal Article] Comparative Study of Opening-Wedge High Tibial Osteotomy With and Without a Combined Computed Tomography–Based and Image-Free Navigation System2016

    • Author(s)
      Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T.
    • Journal Title

      Arthroscopy

      Volume: in press Issue: 10 Pages: 2072-2081

    • DOI

      10.1016/j.arthro.2016.02.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of factor Xa inhibitors following opening-wedge high tibial osteotomy for venous thromboembolism prophylaxis2016

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Mitsuhashi S, Kobayashi A, Aratake M, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: in press Issue: 3 Pages: 779-784

    • DOI

      10.1007/s00167-016-4096-z

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive factors for the progression of spontaneous osteonecrosis of the knee2015

    • Author(s)
      Akamatsu Y, Kobayashi H, Kusayama Y, Aratake M, Kumagai K, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: in press Issue: 2 Pages: 477-484

    • DOI

      10.1007/s00167-015-3839-6

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is the Surgical Epicondylar Axis the Center of Rotation in the Osteoarthritic Knee?2015

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Aratake M, Saito T
    • Journal Title

      The Journal of Arthroplasty

      Volume: 3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis2014

    • Author(s)
      Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Aratake M, Saito T
    • Journal Title

      Journal of Experimental Orthopaedics

      Volume: 1 Pages: 1-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Arthroscopic suture fixation in patients with a tibial intercondylar eminence fracture using a simple device to penetrate the anterior cruciate ligament2014

    • Author(s)
      Aratake M, Akamatsu Y, Mitsugi N, Taki N, Ota H, Shinohara K, Kobayashi H, Saito T
    • Journal Title

      Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology

      Volume: 1 Pages: 67-71

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The surgical epicondylar axis is a consistent reference of the distal femur in the coronal and axial planes2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Muramatsu S, Saito T
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

      Volume: 22 Pages: 2947-2953

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Five- to ten-year outcome following medial opening-wedge high tibial osteotomy with rigid plate fixation in combination with an artificial bone substitute.2014

    • Author(s)
      Saito T, Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y.
    • Journal Title

      Bone Joint J.

      Volume: 96-B Pages: 39-344

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Opening wedge 高位脛骨々切り術前後の骨密度変化2016

    • Author(s)
      三橋祥太、赤松泰、熊谷研、小林秀郎、草山喜洋、小林明裕、齋藤知行
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 人工膝関節置換術前後の脛骨コンポーネント周囲の骨密度変化2016

    • Author(s)
      小林明裕、赤松 泰、熊谷 研、小林秀郎、草山喜洋、三橋祥太、齋藤知行
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2016-05-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] 高位脛骨骨切り術前後の骨密度の骨密度変化2015

    • Author(s)
      三橋 祥太, 赤松 泰, 熊谷 研, 小林 秀郎, 草山 嘉洋, 小林 明裕, 齋藤 知行
    • Organizer
      第42回関東膝を語る会
    • Place of Presentation
      大日本住友製薬東京本社10階ホール(東京都)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] 軟骨下脆弱性骨折の病態と治療 特発性膝骨壊死の発症と低骨密度2015

    • Author(s)
      赤松 泰, 熊谷 研, 小林 秀郎, 草山 喜洋, 齋藤 知行
    • Organizer
      第43回日本関節病学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 高位脛骨々切り術前後の骨密度変化2015

    • Author(s)
      三橋 祥太, 赤松 泰, 熊谷 研, 小林 秀郎, 草山 喜洋, 齋藤 知行
    • Organizer
      第7回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Venous thromboembolism after high tibial osteotomy with oral direct factor Xa inhibition2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatubo R, Muramatsu S, Otoshi A, Honda H, Saito T
    • Organizer
      24th Japanese-Korea Combined Orthopaedic Symposium
    • Place of Presentation
      Hakone, Kanagawa
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Opening wedge high tibial osteotomy using CT based and image free navigation2014

    • Author(s)
      Akamatsu Y, Kumagai K, Kobayashi H, Kusayama Y, Mitsuhashi S, Saito T
    • Organizer
      24th Japanese-Korea Combined Orthopaedic Symposium
    • Place of Presentation
      Hakone, Kanagawa
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Is the surgical epicondylar axis a substitute for the flexion-extension axis?2014

    • Author(s)
      Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Does subchondral sclerosis protect progression of joint space narrowing in patients with varus knee osteoarthritis?2014

    • Author(s)
      Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Mitsugi N, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Changes of the biomarkers in synovial fluid and clinical efficacy of intra-articular injection hyaluronic acid for patients with knee osteoarthritis2014

    • Author(s)
      Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Nakazawa A, Saito T
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Year and Date
      2014-04-24 – 2014-04-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Does subchondral sclerosis protect joint space narrowing in patients with varus knee osteoarthritis?2014

    • Author(s)
      Yasushi Akamatsu
    • Organizer
      OARSI2014
    • Place of Presentation
      Paris, France
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of navigated opening wedge high tibial osteotomy with conventional methods.2013

    • Author(s)
      Yasushi Akamatsu
    • Organizer
      23th Korea Japanese Combined Orthopaedic Symposium
    • Place of Presentation
      Buyeo Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] イメージフリーナビゲーションを用いたオープンウエッジ高位脛骨骨切り術と従来型手術の比較2013

    • Author(s)
      赤松 泰
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      リーガロイヤルホテル広島(広島県広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 低骨密度と特発性大腿骨内側顆部骨壊死の発症との関連2013

    • Author(s)
      赤松 泰
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      リーガロイヤルホテル広島(広島県広島市)
    • Related Report
      2013 Research-status Report
  • [Presentation] CTベースナビゲーション高位脛骨々切り術

    • Author(s)
      赤松 泰
    • Organizer
      第8回日本CAOS研究会
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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