Quantification of subchondral bone sclerosisin patient with osteoarthritic knee

• Project/Area Number: 25350892
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Yokohama City University
• Principal Investigator: AKAMATSU Yasushi 横浜市立大学, 医学部, 准教授 (30348114)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Hideo 横浜市立大学, 附属病院, 助教 (10645998)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: osteoarthritis / knee / computed tomography / bone morphology / bone density / conputed tomography / bone morphometry / bone mineral density / bone quality / osteosrthritis / osteoporosis

Outline of Final Research Achievements

The trabecular bone structure in the femoral medial and lateral condyle was analyzed using three dimensional computed tomographic images. Fifty knees were enrolled in this study between April 2013 and March 2015. The TRI / 3D-BON (RATOC System Engineering Co., Ltd.) software was used. Apparent bone volume fraction and apparent trabecular thickness in the femoral medial condyle were higher than those in the femoral lateral condyle. Apparent trabecular separation and degree of anisotropy in the femoral medial condyle were lower than in the femoral lateral condyle. Apparent trabecular number was no significant difference between the femoral medial and and lateral condyles.

Research Products

• [Journal Article] Comparative Study of Opening-Wedge High Tibial Osteotomy With and Without a Combined Computed Tomography–Based and Image-Free Navigation System (2016)
  • Author(s): Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T.
  • Journal Title: Arthroscopy Volume: in press Issue: 10 Pages: 2072-2081
  • DOI: 10.1016/j.arthro.2016.02.018
  • Peer Reviewed
• [Journal Article] The use of factor Xa inhibitors following opening-wedge high tibial osteotomy for venous thromboembolism prophylaxis (2016)
  • Author(s): Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Mitsuhashi S, Kobayashi A, Aratake M, Saito T
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: in press Issue: 3 Pages: 779-784
  • DOI: 10.1007/s00167-016-4096-z
  • Peer Reviewed
• [Journal Article] Predictive factors for the progression of spontaneous osteonecrosis of the knee (2015)
  • Author(s): Akamatsu Y, Kobayashi H, Kusayama Y, Aratake M, Kumagai K, Saito T
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: in press Issue: 2 Pages: 477-484
  • DOI: 10.1007/s00167-015-3839-6
  • Peer Reviewed
• [Journal Article] Is the Surgical Epicondylar Axis the Center of Rotation in the Osteoarthritic Knee? (2015)
  • Author(s): Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Aratake M, Saito T
  • Journal Title: The Journal of Arthroplasty Volume: 3
  • Peer Reviewed
• [Journal Article] Changes in synovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acid for patients with knee osteoarthritis (2014)
  • Author(s): Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Aratake M, Saito T
  • Journal Title: Journal of Experimental Orthopaedics Volume: 1 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Arthroscopic suture fixation in patients with a tibial intercondylar eminence fracture using a simple device to penetrate the anterior cruciate ligament (2014)
  • Author(s): Aratake M, Akamatsu Y, Mitsugi N, Taki N, Ota H, Shinohara K, Kobayashi H, Saito T
  • Journal Title: Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology Volume: 1 Pages: 67-71
  • Peer Reviewed
• [Journal Article] The surgical epicondylar axis is a consistent reference of the distal femur in the coronal and axial planes (2014)
  • Author(s): Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Muramatsu S, Saito T
  • Journal Title: Knee Surg Sports Traumatol Arthrosc Volume: 22 Pages: 2947-2953
  • Peer Reviewed
• [Journal Article] Five- to ten-year outcome following medial opening-wedge high tibial osteotomy with rigid plate fixation in combination with an artificial bone substitute. (2014)
  • Author(s): Saito T, Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y.
  • Journal Title: Bone Joint J. Volume: 96-B Pages: 39-344
  • Peer Reviewed
• [Presentation] Opening wedge 高位脛骨々切り術前後の骨密度変化 (2016)
  • Author(s): 三橋祥太、赤松泰、熊谷研、小林秀郎、草山喜洋、小林明裕、齋藤知行
  • Organizer: 第89回日本整形外科学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2016-05-12
• [Presentation] 人工膝関節置換術前後の脛骨コンポーネント周囲の骨密度変化 (2016)
  • Author(s): 小林明裕、赤松 泰、熊谷 研、小林秀郎、草山喜洋、三橋祥太、齋藤知行
  • Organizer: 第89回日本整形外科学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2016-05-12
• [Presentation] 高位脛骨骨切り術前後の骨密度の骨密度変化 (2015)
  • Author(s): 三橋 祥太, 赤松 泰, 熊谷 研, 小林 秀郎, 草山 嘉洋, 小林 明裕, 齋藤 知行
  • Organizer: 第42回関東膝を語る会
  • Place of Presentation: 大日本住友製薬東京本社１０階ホール(東京都)
  • Year and Date: 2015-11-28
• [Presentation] 軟骨下脆弱性骨折の病態と治療 特発性膝骨壊死の発症と低骨密度 (2015)
  • Author(s): 赤松 泰, 熊谷 研, 小林 秀郎, 草山 喜洋, 齋藤 知行
  • Organizer: 第43回日本関節病学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] 高位脛骨々切り術前後の骨密度変化 (2015)
  • Author(s): 三橋 祥太, 赤松 泰, 熊谷 研, 小林 秀郎, 草山 喜洋, 齋藤 知行
  • Organizer: 第7回日本関節鏡・膝・スポーツ整形外科学会
  • Place of Presentation: 札幌コンベンションセンター(北海道)
  • Year and Date: 2015-06-18
• [Presentation] Venous thromboembolism after high tibial osteotomy with oral direct factor Xa inhibition (2014)
  • Author(s): Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatubo R, Muramatsu S, Otoshi A, Honda H, Saito T
  • Organizer: 24th Japanese-Korea Combined Orthopaedic Symposium
  • Place of Presentation: Hakone, Kanagawa
  • Year and Date: 2014-06-06
• [Presentation] Opening wedge high tibial osteotomy using CT based and image free navigation (2014)
  • Author(s): Akamatsu Y, Kumagai K, Kobayashi H, Kusayama Y, Mitsuhashi S, Saito T
  • Organizer: 24th Japanese-Korea Combined Orthopaedic Symposium
  • Place of Presentation: Hakone, Kanagawa
  • Year and Date: 2014-06-06
• [Presentation] Is the surgical epicondylar axis a substitute for the flexion-extension axis? (2014)
  • Author(s): Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Saito T
  • Organizer: OARSI2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] Does subchondral sclerosis protect progression of joint space narrowing in patients with varus knee osteoarthritis? (2014)
  • Author(s): Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Mitsugi N, Saito T
  • Organizer: OARSI2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] Changes of the biomarkers in synovial fluid and clinical efficacy of intra-articular injection hyaluronic acid for patients with knee osteoarthritis (2014)
  • Author(s): Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Nakazawa A, Saito T
  • Organizer: OARSI2014
  • Place of Presentation: Paris, France
  • Year and Date: 2014-04-24 – 2014-04-27
• [Presentation] Does subchondral sclerosis protect joint space narrowing in patients with varus knee osteoarthritis? (2014)
  • Author(s): Yasushi Akamatsu
  • Organizer: OARSI2014
  • Place of Presentation: Paris, France
• [Presentation] Comparison of navigated opening wedge high tibial osteotomy with conventional methods. (2013)
  • Author(s): Yasushi Akamatsu
  • Organizer: 23th Korea Japanese Combined Orthopaedic Symposium
  • Place of Presentation: Buyeo Korea
• [Presentation] イメージフリーナビゲーションを用いたオープンウエッジ高位脛骨骨切り術と従来型手術の比較 (2013)
  • Author(s): 赤松 泰
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: リーガロイヤルホテル広島(広島県広島市)
• [Presentation] 低骨密度と特発性大腿骨内側顆部骨壊死の発症との関連 (2013)
  • Author(s): 赤松 泰
  • Organizer: 第86回日本整形外科学会学術総会
  • Place of Presentation: リーガロイヤルホテル広島(広島県広島市)
• [Presentation] CTベースナビゲーション高位脛骨々切り術
  • Author(s): 赤松 泰
  • Organizer: 第8回日本CAOS研究会
  • Place of Presentation: 横浜シンポジア（神奈川県横浜市）