NO/calcium regulation mechanism in stretch-induced glucose uptake of skeletal muscle
| Project/Area Number |
25350893
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Shizuoka |
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Principal Investigator |
OBARA Kazuo 静岡県立大学, 薬学部, 講師 (60117611)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨格筋 / 糖代謝 / ストレッチ / インテグリン / NO / リアノジン受容体 / カルシウム / CaMKII / 糖取り込み / ニトロシル化 / ＮＯ / ＧＬＵＴ４ / GLUT4 |
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| Outline of Final Research Achievements |
The mechanism of stretch-stimulated glucose uptake in skeletal muscle was investigated. Our results suggest that stretch produces NO through nitric oxide synthase activation and increases calcium release from sarcoplasmic reticulum (SR) by S-nitrosylation of ryanodine receptor of SR, resulting increase in glucose uptake through CaMKII activation. Our results also suggest that stretch-induced glucose uptake involves insulin- and contraction-independent pathways.
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Report
(4 results)
Research Products
(9 results)
