| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we considered the controlling mechanisms through the immunoregulatory receptors of an inflammatory response with skeletal muscle injury and regeneration process using cardiotoxin-induced skeletal muscle injury model. As a result, it was indicated that activation receptor signal molecules regulate the infiltration of F4/80 positive cells into the damaged area in lesion repair and regenerative process of the injured skeletal muscle. In addition, it was show that this activation signal regulates the gene expression of some chemokine receptors in F4/80 positive cells. Moreover, it was indicated that these activation receptor signal molecules also participate in M1/M2 differentiation of F4/80 positive cells. Therefore, a possibility suggested that activating immunoregulatory receptors are involved in the lesion repair and regenerative process of the injured skeletal muscle.
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